DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Zfp219

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001240623.1	Gene:	Zfp219 / 69890	MGIID:	1917140	Length:	726	Species:	Mus musculus

Alignment Length:	1016	Identity:	193/1016 - (18%)
Similarity:	275/1016 - (27%)	Gaps:	488/1016 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 CKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPN 387
            |..|||.|...|.|.:|||:|.|.:.|.|..||.:...:..|:.|.:.|
Mouse    63 CPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTH---------------- 111

  Fly   388 VGHSGQGQVQGEQYPIRLPFAPPV--------------APVGQEQHQNQVEEPEEIRQEIPVPQA 438
                     |.|:     |.:|..              |.:|:.:....::..         |.|
Mouse   112 ---------QPER-----PRSPAARLLLELEERALLREARLGRARSSGGMQSS---------PAA 153

  Fly   439 EDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAV 503
            |.|::|.|                         |||........|            .|.:|||
Mouse   154 EGLARPQV-------------------------PSSSAFRCPFCK------------GKFRTSA- 180

  Fly   504 SPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQ 568
                 :|||    ||||.           .:|.:.||....   ....|:|:....|:..:..:.
Mouse   181 -----ERER----HLHIL-----------HRPWKCSLCSFG---SSQEEELLHHSLTAHGASERP 222

  Fly   569 LVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERP---------------------FRCK 612
            |......:...|.|       ...||:|:..........|                     |||:
Mouse   223 LAATSTPEPPPPPQ-------QEPRSALEPEPEPEPRPEPDREANPAPTPAPPEEPPAPPEFRCQ 280

  Fly   613 ICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMD------DGSGG 671
            :||::|.....||.||..||..    ....||||.:.|.....|:.|:::||..      .|.|.
Mouse   281 VCGQSFTQSWFLKGHMRKHKAS----FDHACPVCGRCFKEPWFLKNHMKVHTSKLGPLRAPGPGS 341

  Fly   672 QGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDS 736
            ..|.|..|.:...|..|      .||.:..|
Mouse   342 APARAPQPPDLSLLAYE------PLGPALLL---------------------------------- 366

  Fly   737 RDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNS 801
                   ...|.|.||.                                  |.|:: |...|..:
Mouse   367 -------APAPAPAERR----------------------------------EPPSL-LGYLSVRA 389

  Fly   802 GRIFATGLANGA-AGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFM 865
            |.:...|  .|| .|||...||
Mouse   390 GEVRPNG--EGADPGGGRSYGG------------------------------------------- 409

  Fly   866 GLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDA-------GSPYGAKLTLN 923
                        |:.|||  ||.:..:....:||    .:..:..:|       |...|:..:|:
Mouse   410 ------------FRPLPS--ALPNRARRHRTEEP----EEEEEVVEAEEESWARGRSLGSLTSLH 456

  Fly   924 PNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATS 988
            ||      |.           |.|..|.||   ..|..:....||:..:..|.:..| :|.|||.
Mouse   457 PN------PG-----------EGSGQPAPA---AGTQARSTATQEENGLLVGGTRSE-AGRGATG 500

  Fly   989 NYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSS 1053
            .                                                   .|..|.::|.|:.
Mouse   501 K---------------------------------------------------DCPFCGKSFRSAH 514

  Fly  1054 ALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMRPGPNSGQG 1118
            .|::|:|.|||::|::|..|..|.|..|:||.|:..|       .|.:|.|          :|.|
Mouse   515 HLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRH-------HREQRSS----------AGPG 562

  Fly  1119 HPGSSAEQEFMQRRPELFFPYLPPFFNGLPPKPGELSP--GAFP------------NIPPPPFAN 1169
            .|                 |..||     |.:.|.|.|  ||.|            :..||..:.
Mouse   563 PP-----------------PEPPP-----PSQRGSLQPQSGAKPTQASATWVEGTASTRPPSSST 605

  Fly  1170 G---GKYPYPPG----------------------------------------LLGFPGFLAQHPY 1191
            |   .:.|..||                                        ..|.|..:|.|..
Mouse   606 GPGSRRKPASPGRTLRNGRGGEAEPLDLSLRAGPGGEAGAGGALHRCLFCPFATGAPELMALHLQ 670

  Fly  1192 ILERRSSS--------------KSPTPEPAQSPALREEEGS 1218
            :...|.:.              ::|:.|...||.| |||||
Mouse   671 VHHSRRARGRRQPRADTSPTYVRAPSGETPPSPPL-EEEGS 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	10/19 (53%)
		C2H2 Zn finger	323..343	CDD:275368	10/19 (53%)
		zf-H2C2_2	335..360	CDD:290200	10/24 (42%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		C2H2 Zn finger	583..603	CDD:275368	3/19 (16%)
		zf-H2C2_2	595..620	CDD:290200	8/45 (18%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	6/47 (13%)
		zf-C2H2	1040..1062	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	10/24 (42%)
		C2H2 Zn finger	1070..1090	CDD:275368	8/19 (42%)
Zfp219	NP_001240623.1	C2H2 Zn finger	63..83	CDD:275368	10/19 (53%)
		C2H2 Zn finger	91..111	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..164		8/58 (14%)
		C2H2 Zn finger	169..187	CDD:275368	9/39 (23%)
		C2H2 Zn finger	195..211	CDD:275368	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..278		7/66 (11%)
		zf-C2H2	277..299	CDD:395048	10/21 (48%)
		C2H2 Zn finger	279..299	CDD:275368	8/19 (42%)
		zf-C2H2	305..327	CDD:395048	7/21 (33%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..498		34/190 (18%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		zf-C2H2	503..523	CDD:395048	7/19 (37%)
		zf-H2C2_2	515..537	CDD:404364	9/21 (43%)
		zf-H2C2_5	529..552	CDD:404746	9/29 (31%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..645		25/138 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..726		11/38 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836448
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930