DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Sall4

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_003749680.1	Gene:	Sall4 / 686412	RGDID:	1597672	Length:	1070	Species:	Rattus norvegicus

Alignment Length:	1257	Identity:	333/1257 - (26%)
Similarity:	480/1257 - (38%)	Gaps:	396/1257 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DSNNNGTEPQMEAEAVPESDTERETAEERGEEQE---PEN---------SNEAL------DLSLI 99
            :.:.....|:..:.||..|.:.::..:|.|....   .||         ..||.      |:|.:
  Rat   102 NDSEGAVPPEDFSRAVLGSPSNKDGLQENGGSSSGDLKENLGTDSILYLKTEATQPPAPQDISYL 166

  Fly   100 SSGGRESLPGSGHVSLEALQHTKVAVAQFAATAMAGNHQSA-DLAMVQSTIFNVQRQHLMQLQLI 163
            ..|    ...:.:|:|:||:.|||||.|.:....|....:| .:..:...|..:|:|.|.|:||.
  Rat   167 PKG----KVANTNVTLQALRGTKVAVNQRSTDVPAAPVPAALSIPWILEQILCLQQQQLQQIQLT 227

  Fly   164 QHLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQDQESRREEN 228
            :.::.|:....|.||    ||.      ....:..|..:|.:.:::.:.|...:.....|::..|
  Rat   228 EQIRVQVNMWAAHAL----HSG------VAGADTLKALSNHVSQQVSVSQQVSAAVALLSQKASN 282

  Fly   229 SKTDKRGTEDRKAEPEGYQSMMCDISSSLASSIITNHDPPPAPN----EPNCL-------EMLQR 282
            ........:..|.......|....:||......:........||    .||.|       .:||.
  Rat   283 PTLSLDALKQAKLPHAAVPSTASSLSSGFTPFALKPDGTRVLPNFMSRLPNALLPQTPGSVLLQS 347

  Fly   283 RTEEV-LDSAS------QSLHAAQMQEEYSEYASKEAQSRGEIF--KHRCKYCGKIFGSYSALQI 338
            ....| ||.:.      |:|.|:.:          :|:::.|:.  ||:|:||.|:||:.|:|||
  Rat   348 PFSTVTLDQSKKGKGKPQNLSASML----------DAKTKDEVVLGKHKCRYCSKVFGTDSSLQI 402

  Fly   339 HLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQI------FPPMLLPPGVAPNVGHSGQGQVQ 397
            ||||||||||:||.|||.:||||||||||:.||.|:      |.......|.:....|
  Rat   403 HLRSHTGERPYVCPVCGHRFTTKGNLKVHFHRHPQVKANPQLFATEFQDKGASSTSPH------- 460

  Fly   398 GEQYPIRLPFAPPVAPVGQEQHQNQVE-EPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERVKT 461
                     :|.|| |:..::....|: ||      :||.....:..|    ::.:..|     .
  Rat   461 ---------YALPV-PIPVDESSLSVDTEP------VPVTGTPSIGLP----QKLTSGP-----N 500

  Fly   462 PKEVKTDAALPS----SEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAK 522
            ||:: ...:||:    ...||.|:..|::.:    |.:|       :||
  Rat   501 PKDL-MGGSLPNDIQPGPSPESEVGLPLLGA----GMMR-------NPP---------------- 537

  Fly   523 LVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQ 587
              |.........|                      :..|||.||||||:||:...||||:|:.|.
  Rat   538 --RAGGFQGTGAP----------------------ESGSETLKLQQLVENIDKATTDPNECLICH 578

  Fly   588 KVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSN 652
            :|:||:|||:||.|||||||||:||||||||:||||||.|:.:|:....:::|..||:|.:||:|
  Rat   579 RVLSCQSSLKMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNMAVKTQHSCPICQKKFTN 643

  Fly   653 GIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFST----TISDHSG 713
            .::||||||:|     .|||......|                   ....||:.    .:|::.|
  Rat   644 AVMLQQHIRMH-----MGGQIPNTPLP-------------------ESPCDFTVPEPMAVSENGG 684

  Fly   714 QRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSNPD 778
            ......              :|:.:...|..|                      |..       |
  Rat   685 GSGVCQ--------------EDAVEGMEAEEA----------------------CIQ-------D 706

  Fly   779 LTGGRSE-SGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAARE 842
            :.||.|. |..:|...|:|||        .|....|.....|.|.||.|           |..|:
  Rat   707 VPGGPSTVSAPLPGTHLASPS--------LGFPVMAPLDAQGRGALPAL-----------ALQRQ 752

  Fly   843 EMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRP 907
            .....|...|....|.......||....|:                   :|..|.|.....|..|
  Rat   753 SSRESGSLEAGDSCLTNDSSSLMGDQECPS-------------------RSPDATETMCYQAVSP 798

  Fly   908 QCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMV 972
            ..|.|||                  ..|.|..|.|
  Rat   799 ANSQAGS------------------VKSRSPDGHK------------------------------ 815

  Fly   973 EEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPT-------- 1029
            .||..:......|.|| .|.....|:.:.:|:::     |.|         ..|||:
  Rat   816 AEGVESCRVDTEGRTS-LPSTFIRAQPTFVKVEV-----PGS---------FVGPPSVPSGMTPL 865

  Fly  1030 -SSLDPPVN--NKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHM 1091
             :|..||..  .:|.|..|.:||||:||||||.|||||:|||.||:|.:|||||||||||..||.
  Rat   866 LASQQPPRRQAKQHSCTRCGKNFSSASALQIHERTHTGEKPFVCNICARAFTTKGNLKVHYMTHG 930

  Fly  1092 WTNPTSRRGRRMSLELPMRPGPNSGQGHPGSSAEQEFMQRRPELFFPYL---PPFFN-------- 1145
            ..|.::||||::::|..|     :..|..|..|.:.|.:   ||..|.:   |..:|
  Rat   931 TNNNSARRGRKLAIENTM-----AALGAEGKRAPEVFPK---ELLSPTVSVDPATWNQYTSVLNG 987

  Fly  1146 GLPPKPGELS---PGAFPNIP----------PPPF----------------ANGGKYPYPPGLLG 1181
            ||..|..|:|   .|..|.:|          .|..                |..|....|    |
  Rat   988 GLAMKTNEISVIQSGGIPTLPVSLGASSVVSNPTLSKLDGSQTGGSGAMSGAMSGNLEKP----G 1048

  Fly  1182 FPGFLAQH--PYILERRSSSKS 1201
            .|..:|:|  |:.||....:.|
  Rat  1049 VPDGVAKHQFPHFLEENKIAVS 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	14/21 (67%)
		C2H2 Zn finger	323..343	CDD:275368	13/19 (68%)
		zf-H2C2_2	335..360	CDD:290200	19/24 (79%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	11/19 (58%)
		zf-H2C2_2	595..620	CDD:290200	21/24 (88%)
		C2H2 Zn finger	611..631	CDD:275368	15/19 (79%)
		C2H2 Zn finger	643..663	CDD:275368	12/19 (63%)
		lambda-1	1013..>1061	CDD:212564	20/58 (34%)
		zf-C2H2	1040..1062	CDD:278523	14/21 (67%)
		C2H2 Zn finger	1042..1062	CDD:275368	13/19 (68%)
		zf-H2C2_2	1054..1079	CDD:290200	18/24 (75%)
		C2H2 Zn finger	1070..1090	CDD:275368	14/19 (74%)
Sall4	XP_003749680.1	COG5048	385..>676	CDD:227381	137/398 (34%)
		zf-C2H2	385..407	CDD:278523	14/21 (67%)
		C2H2 Zn finger	387..407	CDD:275368	13/19 (68%)
		zf-H2C2_2	399..424	CDD:290200	19/24 (79%)
		C2H2 Zn finger	415..435	CDD:275368	14/19 (74%)
		C2H2 Zn finger	574..594	CDD:275368	11/19 (58%)
		zf-H2C2_2	586..611	CDD:290200	21/24 (88%)
		C2H2 Zn finger	602..622	CDD:275368	15/19 (79%)
		zf-C2H2	632..654	CDD:278523	12/21 (57%)
		C2H2 Zn finger	634..654	CDD:275368	12/19 (63%)
		lambda-1	795..>900	CDD:212564	39/167 (23%)
		COG5048	856..>935	CDD:227381	42/78 (54%)
		C2H2 Zn finger	881..901	CDD:275368	13/19 (68%)
		zf-H2C2_2	893..918	CDD:290200	18/24 (75%)
		C2H2 Zn finger	909..929	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11605
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1911
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm45072
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23233
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970