DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and ZNF574

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001317448.1	Gene:	ZNF574 / 64763	HGNCID:	26166	Length:	986	Species:	Homo sapiens

Alignment Length:	1218	Identity:	237/1218 - (19%)
Similarity:	349/1218 - (28%)	Gaps:	514/1218 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RNRINYRGTGGTRSGSGERERD-RDRDRDRDRDR-------ERDRDTLLAKE---LDADSN---- 55
            |.|:..|||.....|.|.|..| |..|....|.:       |...:|:|..|   :.::.|
Human    52 RQRMRLRGTERASLGPGRRLGDSRGTDMPGARAQGLAAAMTEESEETVLYIEHRYVCSECNQLYG 116

  Fly    56 --------NNGTEPQMEAEAVPESD----TERETAEERG-------EEQ-----------EPENS 90
                    .|...||...|.|..:|    ...:||...|       |.|           .|...
Human   117 SLEEVLMHQNSHVPQQHFELVGVADPGVTVATDTASGTGLYQTLVQESQYQCLECGQLLMSPSQL 181

  Fly    91 NEALDLSLISSGGRESLPGSGHVSLEALQHTKV------AVAQFAATAMAGNHQSADLAMVQSTI 149
            .|..:|.|.....:|::|.........|..:.:      ..|.||:..:..||:..
Human   182 LEHQELHLKMMAPQEAVPAEPSPKAPPLSSSTIHYECVDCKALFASQELWLNHRQT--------- 237

  Fly   150 FNVQRQHLMQLQLIQHLQSQLKRAEA-------AALG----------RHSHSDEEE-EEPEPEPE 196
                           ||::...:|.|       ..||          .||:...|| .|....|.
Human   238 ---------------HLRATPTKAPAPVVLGSPVVLGPPVGQARVAVEHSYRKAEEGGEGATVPS 287

  Fly   197 PKKQPTNGLKE-ELELEQGPESEQDQESRRE--ENSKTDKRGTEDRKAEPEGYQSMMCDISSSLA 258
            .....|..:.| ||.|.:..|..|..:...:  |:..|..........||...|.:.   :||.|
Human   288 AAATTTEVVTEVELLLYKCSECSQLFQLPADFLEHQATHFPAPVPESQEPALQQEVQ---ASSPA 349

  Fly   259 SSIITNHDPPPAPNEP---------------------NCLEMLQRRTEEVLDSASQSLHAA--QM 300
            ...::..||.||.:..                     |..|.....|:|:..||...|..:  |:
Human   350 EVPVSQPDPLPASDHSYELRNGEAIGRDRRGRRARRNNSGEAGGAATQELFCSACDQLFLSPHQL 414

  Fly   301 QEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLK 365
            |:....:       |..:||  |..|.::|.|.|:|..||..|:.|..|:|..||..|.|:..|.
Human   415 QQHLRSH-------REGVFK--CPLCSRVFPSPSSLDQHLGDHSSESHFLCVDCGLAFGTEALLL 470

  Fly   366 VHYQRHTQIFPPMLLPPGVAPNVGHS--------------------GQGQVQGEQYPIRLPFAPP 410
            .|.:.||             ||..||                    |.|.|     |:      |
Human   471 AHRRAHT-------------PNPLHSCPCGKTFVNLTKFLYHRRTHGVGGV-----PL------P 511

  Fly   411 VAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPSSE 475
            ..||          .|||.....|.|...:..:|                              |
Human   512 TTPV----------PPEEPVIGFPEPAPAETGEP------------------------------E 536

  Fly   476 KPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSL 540
            .||..:|:               :||| .|                           :.|..|..
Human   537 APEPPVSE---------------ETSA-GP---------------------------AAPGTYRC 558

  Fly   541 AQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTG 605
            ....|          |..|..:.::.|:.|..:|.:    ::|..|.|:...:|.::.|:|||||
Human   559 LLCSR----------EFGKALQLTRHQRFVHRLERR----HKCSICGKMFKKKSHVRNHLRTHTG 609

  Fly   606 ERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSG 670
            ||||.|..|.:.|.:..||..|...|..:.|    ::|..|.:.|:....|:||..:|...
Human   610 ERPFPCPDCSKPFNSPANLARHRLTHTGERP----YRCGDCGKAFTQSSTLRQHRLVHAQH---- 666

  Fly   671 GQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDD 735
                   .|...:..|:......:.|         .....|:|:
Human   667 -------FPYRCQECGVRFHRPYRLL---------MHRYHHTGE--------------------- 694

  Fly   736 SRDNSSAATATPHPLE-RERDREKERER------------RIPNDCSDERSHSNPDLTGGRSESG 787
                        :|.: ||..|.....|            |.|:.|
Human   695 ------------YPYKCRECPRSFLLRRLLEVHQLVVHAGRQPHRC------------------- 728

  Fly   788 EMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHA 852
                                                |..|...|.:|.|    ||...|...|.|
Human   729 ------------------------------------PSCGAAFPSSLRL----REHRCAAAAAQA 753

  Fly   853 KFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYG 917
                            |....|..|.|.:.|.|.|::| ::.||   |.|..:
Human   754 ----------------PRRFECGTCGKKVGSAARLQAH-EAAHA---AAGPGE------------ 786

  Fly   918 AKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGS 982
                    :.||:||:       .:.|.::..  |..:|.|.
Human   787 --------VLAKEPPA-------PRAPRATRA--PVASPAAL----------------------- 811

  Fly   983 GTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRR 1047
            |:.||::                      ||:|           .....|:        |..|::
Human   812 GSTATAS----------------------PAAP-----------ARRRGLE--------CSECKK 835

  Fly  1048 NFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNP 1095
            .||:.::||:|.|.|||::|:.|..|.|||....:||.|...|....|
Human   836 LFSTETSLQVHRRIHTGERPYPCPDCGKAFRQSTHLKDHRRLHTGERP 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	8/21 (38%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..360	CDD:290200	10/24 (42%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	595..620	CDD:290200	13/24 (54%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		C2H2 Zn finger	643..663	CDD:275368	6/19 (32%)
		lambda-1	1013..>1061	CDD:212564	10/47 (21%)
		zf-C2H2	1040..1062	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1042..1062	CDD:275368	8/19 (42%)
		zf-H2C2_2	1054..1079	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1070..1090	CDD:275368	8/19 (42%)
ZNF574	NP_001317448.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000