DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment salr and ZFP62

DIOPT Version :9

Sequence 1:NP_001245983.1 Gene:salr / 34568 FlyBaseID:FBgn0000287 Length:1267 Species:Drosophila melanogaster
Sequence 2:NP_001166109.1 Gene:ZFP62 / 643836 HGNCID:23241 Length:900 Species:Homo sapiens


Alignment Length:1104 Identity:219/1104 - (19%)
Similarity:347/1104 - (31%) Gaps:438/1104 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 HSHSDEEEEEP------------------EPEPEPKKQPTNGLKEELELEQGPESE----QDQES 223
            |..:..|:|||                  :|.||.|...|.....::|.:|....|    :|:.|
Human     3 HLKTSTEDEEPTEEYENVGNAASKWPKVEDPMPESKVGDTCVWDSKVENQQKKPVENRMKEDKSS 67

  Fly   224 RREENSKTDKRGTEDRKAEPEGYQSMMCDISSSLASSIITNHDPP---------------PAPNE 273
            .||..||.  :.|.:.|.|.||..|   :.|..|:...||:...|               ...:.
Human    68 IREAISKA--KSTANIKTEQEGEAS---EKSLHLSPQHITHQTMPIGQRGSEQGKRVENINGTSY 127

  Fly   274 PNCLEMLQRRTEEV-----LDSASQS------------LHAAQMQEE------------------ 303
            |:    ||::|..|     .|...:|            :|..:.:.|                  
Human   128 PS----LQQKTNAVKKLHKCDECGKSFKYNSRLVQHKIMHTGEKRYECDDCGGTFRSSSSLRVHK 188

  Fly   304 --------------------YSEYASKEAQSRGE-----------------IFKHR--------- 322
                                ||...:.::...||                 :.:|:         
Human   189 RIHTGEKPYKCEECGKAYMSYSSLINHKSTHSGEKNCKCDECGKSFNYSSVLDQHKRIHTGEKPY 253

  Fly   323 -CKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAP 386
             |..|||.|.:.|.|::|.|.||||:|:.|::||..|:....|:||.:.||              
Human   254 ECGECGKAFRNSSGLRVHKRIHTGEKPYECDICGKTFSNSSGLRVHKRIHT-------------- 304

  Fly   387 NVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMV----- 446
                       ||:     |:                             :.::..|..:     
Human   305 -----------GEK-----PY-----------------------------ECDECGKAFITCRTL 324

  Fly   447 ---------------KEKEKSHSPVERVKTPKEVKTDAALPSSEKPEK--EISKPVVTSSRRNGS 494
                           .|.|||.:....:...|.:.|      .|||.:  |..|     :.||.|
Human   325 LNHKSIHFGDKPYKCDECEKSFNYSSLLIQHKVIHT------GEKPYECDECGK-----AFRNSS 378

  Fly   495 ---VRKRQTSAVSPPQED---RERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWED 553
               |.||..:...|.:.|   :.......|.:.|.:.....:.|.:....|.         |:..
Human   379 GLIVHKRIHTGEKPYKCDVCGKAFSYSSGLAVHKSIHPGKKAHECKECGKSF---------SYNS 434

  Fly   554 LIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAF 618
            |:...:|..|.:             .|..|..|.|.....:.|::|.|.||||:|::|.:||:|:
Human   435 LLLQHRTIHTGE-------------RPYVCDVCGKTFRNNAGLKVHRRLHTGEKPYKCDVCGKAY 486

  Fly   619 ATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAE 683
            .::.:||.|..||..:.|    :||..|.:.|:....|:||.||||.:...|     ....|:|.
Human   487 ISRSSLKNHKGIHLGEKP----YKCSYCEKSFNYSSALEQHKRIHTREKPFG-----CDECGKAF 542

  Fly   684 RLGIEDQNS----NKSLGTSDT-----------LDFSTTI---SDHSGQR----SESSQGGDFDE 726
            |     .||    :|.:.|.:.           :..|:.|   |.|.|::    .|..:.  |..
Human   543 R-----NNSGLKVHKRIHTGERPYKCEECGKAYISLSSLINHKSVHPGEKPFKCDECEKA--FIT 600

  Fly   727 FMTM---------------DSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSN 776
            :.|:               |..:.|.:.:|..:.......||:..|.:|..::..:.|..:.|. 
Human   601 YRTLTNHKKVHLGEKPYKCDVCEKSFNYTSLLSQHRRVHTREKPYECDRCEKVFRNNSSLKVHK- 664

  Fly   777 PDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAR 841
                  |..:||.|                                                   
Human   665 ------RIHTGERP--------------------------------------------------- 672

  Fly   842 EEMHALGHAHAKFPLLPFGPLGFMGLHP--PPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHA 904
            .|....|.|:.....|    :.....||  .|:.|:.|.|...|...|.||.:....::|.    
Human   673 YECDVCGKAYISHSSL----INHKSTHPGRTPHTCDECGKAFFSSRTLISHKRVHLGEKPF---- 729

  Fly   905 QRPQCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQ 969
               :|.:.|..:                |.||..|..|...:...|:..:...    |...:...
Human   730 ---KCVECGKSF----------------SYSSLLSQHKRIHTGEKPYVCDRCG----KAFRNSSG 771

  Fly   970 LMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDP 1034
            |.|.:....||         .|.|..:..::.:     :|                    |||  
Human   772 LTVHKRIHTGE---------KPYECDECGKAYI-----SH--------------------SSL-- 800

  Fly  1035 PVNNK--------HFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTH 1090
             :|:|        :.|. |.::|:..|.|..|.|.|||.||::||.|.|||..:.||..|..||
Human   801 -INHKSVHQGKQPYNCE-CGKSFNYRSVLDQHKRIHTGKKPYRCNECGKAFNIRSNLTKHKRTH 862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
salrNP_001245983.1 zf-C2H2 321..343 CDD:278523 10/31 (32%)
C2H2 Zn finger 323..343 CDD:275368 9/19 (47%)
zf-H2C2_2 335..360 CDD:290200 12/24 (50%)
C2H2 Zn finger 351..371 CDD:275368 7/19 (37%)
C2H2 Zn finger 583..603 CDD:275368 6/19 (32%)
zf-H2C2_2 595..620 CDD:290200 12/24 (50%)
C2H2 Zn finger 611..631 CDD:275368 7/19 (37%)
C2H2 Zn finger 643..663 CDD:275368 7/19 (37%)
lambda-1 1013..>1061 CDD:212564 11/55 (20%)
zf-C2H2 1040..1062 CDD:278523 7/21 (33%)
C2H2 Zn finger 1042..1062 CDD:275368 7/19 (37%)
zf-H2C2_2 1054..1079 CDD:290200 14/24 (58%)
C2H2 Zn finger 1070..1090 CDD:275368 9/19 (47%)
ZFP62NP_001166109.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..97 26/98 (27%)
COG5048 125..552 CDD:227381 107/536 (20%)
C2H2 Zn finger 143..163 CDD:275368 2/19 (11%)
C2H2 Zn finger 171..191 CDD:275368 0/19 (0%)
C2H2 Zn finger 199..219 CDD:275368 2/19 (11%)
C2H2 Zn finger 227..247 CDD:275368 1/19 (5%)
C2H2 Zn finger 255..275 CDD:275368 9/19 (47%)
C2H2 Zn finger 283..303 CDD:275368 7/19 (37%)
C2H2 Zn finger 311..331 CDD:275368 1/19 (5%)
C2H2 Zn finger 339..359 CDD:275368 5/19 (26%)
C2H2 Zn finger 367..387 CDD:275368 8/24 (33%)
C2H2 Zn finger 395..415 CDD:275368 3/19 (16%)
C2H2 Zn finger 423..443 CDD:275368 4/28 (14%)
COG5048 447..860 CDD:227381 119/555 (21%)
C2H2 Zn finger 451..471 CDD:275368 6/19 (32%)
C2H2 Zn finger 479..499 CDD:275368 7/19 (37%)
C2H2 Zn finger 507..527 CDD:275368 7/19 (37%)
C2H2 Zn finger 535..555 CDD:275368 6/24 (25%)
C2H2 Zn finger 563..583 CDD:275368 3/19 (16%)
C2H2 Zn finger 591..611 CDD:275368 3/21 (14%)
C2H2 Zn finger 619..639 CDD:275368 3/19 (16%)
C2H2 Zn finger 647..667 CDD:275368 4/26 (15%)
C2H2 Zn finger 675..695 CDD:275368 3/23 (13%)
C2H2 Zn finger 703..723 CDD:275368 7/19 (37%)
C2H2 Zn finger 731..751 CDD:275368 7/35 (20%)
C2H2 Zn finger 759..779 CDD:275368 3/23 (13%)
C2H2 Zn finger 787..807 CDD:275368 6/47 (13%)
C2H2 Zn finger 815..834 CDD:275368 7/19 (37%)
C2H2 Zn finger 842..862 CDD:275368 9/19 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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