DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and SALL1

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_002959.2	Gene:	SALL1 / 6299	HGNCID:	10524	Length:	1324	Species:	Homo sapiens

Alignment Length:	1369	Identity:	394/1369 - (28%)
Similarity:	560/1369 - (40%)	Gaps:	338/1369 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DRDRERDRDTL-LAKELDAD--SNNNG--TEPQMEAEAVPESDTERETAEERGEEQEPENSNEAL 94
            |...|:..||: ...::|..  |.:||  .|..||.||...:.:...|:........|.:|:.
Human    92 DNPDEQMNDTVNKTDQVDCSDLSEHNGLDREESMEVEAPVANKSGSGTSSGSHSSTAPSSSSS-- 154

  Fly    95 DLSLISSGG-----------RESLPGSG-------------HVSLEALQHTKVAVAQFAATAMAG 135
              |..||||           ..|||..|             :|.:|.||.||||||||:..|..|
Human   155 --SSSSSGGGGSSSTGTSAITTSLPQLGDLTTLGNFSVINSNVIIENLQSTKVAVAQFSQEARCG 217

  Fly   136 NHQSADLAM--VQSTIFNVQRQHLMQLQLIQ---------------------------------- 164
            ......||:  :...:..:|:|.:.|||||:
Human   218 GASGGKLAVPALMEQLLALQQQQIHQLQLIEQIRHQILLLASQNADLPTSSSPSQGTLRTSANPL 282

  Fly   165 -----HLQSQLKRAE--AAALGRHSHSDEEEEEPEPEPEPKKQ------PTN-GLKEELELEQG- 214
                 ||..||..|.  |.:|...|.|....::..|...|:..      |:| |....:.:...
Human   283 STLSSHLSQQLAAAAGLAQSLASQSASISGVKQLPPIQLPQSSSGNTIIPSNSGSSPNMNILAAA 347

  Fly   215 ---PESEQDQESRREENSKTDKRGTEDRKAEPEGYQSMMCDISSSL------ASSIITNHDPPPA 270
               |.||:...|...  |...........:......|::...|:.|      |:|:.    |.|.
Human   348 VTTPSSEKVASSAGA--SHVSNPAVSSSSSPAFAISSLLSPASNPLLPQQASANSVF----PSPL 406

  Fly   271 PNEPNCLEMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGE--IFKHRCKYCGKIFGSY 333
            ||.....|          |..|.|..|.|.:.:.....:.||:|..:  .|||:|::|.|:|||.
Human   407 PNIGTTAE----------DLNSLSALAQQRKSKPPNVTAFEAKSTSDEAFFKHKCRFCAKVFGSD 461

  Fly   334 SALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAP----NVGHSGQG 394
            ||||||||||||||||.||:||::|:||||||||:|||.:.:|.:.:.|...|    |:..|
Human   462 SALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEHLDNIPTS--- 523

  Fly   395 QVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERV 459
              .|..|.:.:   ||..||........|.........:|:|.......|.:|.:|.:..|:...
Human   524 --TGIPYGMSI---PPEKPVTSWLDTKPVLPTLTTSVGLPLPPTLPSLIPFIKTEEPAPIPISHS 583

  Fly   460 KT--PKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERD---LVEHLH 519
            .|  |..||:|:..|.|             ::|..|.:.:....:..||...:..:   :...:.
Human   584 ATSPPGSVKSDSGGPES-------------ATRNLGGLPEEAEGSTLPPSGGKSEESGMVTNSVP 635

  Fly   520 IAKLVRRSSASRESQPAEYSLAQMERIIDKSWED---------LIEIDKTSETSKLQQLVDNIEN 575
            .|.....||.:.:..||..:......::....|.         |::..:.||||||||||:||:.
Human   636 TASSSVLSSPAADCGPAGSATTFTNPLLPLMSEQFKAKFPFGGLLDSAQASETSKLQQLVENIDK 700

  Fly   576 KLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQ 640
            |.||||:||.|.:|:||:|:|:||.|||||||||:||||||||.||||||.|.|:|:..||:|.|
Human   701 KATDPNECIICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHYSVHRAMPPLRVQ 765

  Fly   641 FKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFS 705
            ..||:|.:||:|.::||||||:|     .|||......|..      ..::.....|:.|..:|.
Human   766 HSCPICQKKFTNAVVLQQHIRMH-----MGGQIPNTPVPDS------YSESMESDTGSFDEKNFD 819

  Fly   706 TTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSD 770
             .:.:.|.:..|....|...:  |..|.|.|:|:.|   ::|.|||.......|.:.::.|....
Human   820 -DLDNFSDENMEDCPEGSIPD--TPKSADASQDSLS---SSPLPLEMSSIAALENQMKMINAGLA 878

  Fly   771 E------RSHSNPDLTG------GRSESGEMPAMDLSSPS-------------SNSGR------- 803
            |      :|..|..:.|      ..|..|:|.:....||:             |||.:
Human   879 EQLQASLKSVENGSIEGDVLTNDSSSVGGDMESQSAGSPAISESTSSMQALSPSNSTQEFHKSPS 943

  Fly   804 -----------IFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEM---HALGHAHAKF 854
                       .||.||:.....||:               |.|.::..|::   .:||
Human   944 IEEKPQRAVPSEFANGLSPTPVNGGA---------------LDLTSSHAEKIIKEDSLG------ 987

  Fly   855 PLLPFGPLG-FMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRP-QCSDAGSPYG 917
            .|.||...| |..     ..|::|.|.....:||:.|.:| |.||       || .|:.....:.
Human   988 ILFPFRDRGKFKN-----TACDICGKTFACQSALDIHYRS-HTKE-------RPFICTVCNRGFS 1039

  Fly   918 AKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGS 982
            .|..|..::...:.....|     :|.|.|:...|.:|....|
Human  1040 TKGNLKQHMLTHQMRDLPS-----QLFEPSSNLGPNQNSAVIP---------------------- 1077

  Fly   983 GTGATSNYPQEAGDAEQSLMKMQLH--AHRFPASPLDFQQALMSAGPPTSSLDPPV--------- 1036
                        .::..||:|.:::  .|..|....|...:.:.:||.:||...||
Human  1078 ------------ANSLSSLIKTEVNGFVHVSPQDSKDTPTSHVPSGPLSSSATSPVLLPALPRRT 1130

  Fly  1037 NNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGR 1101
            ..:|:|:.|.:.||||||||||.|||||:|||.|.:|.:|||||||||||||||||.:..:||||
Human  1131 PKQHYCNTCGKTFSSSSALQIHERTHTGEKPFACTICGRAFTTKGNLKVHMGTHMWNSTPARRGR 1195

  Fly  1102 RMSLELPM-----RP-----------GPNSGQGHPGSSAEQEFMQRRPELFFPYLPPFFNGLPPK 1150
            |:|::.||     .|           ...||.|.|.|...|            |.....|||..|
Human  1196 RLSVDGPMTFLGGNPVKFPEMFQKDLAARSGSGDPSSFWNQ------------YAAALSNGLAMK 1248

  Fly  1151 PGELSPGAFPNIPPPPFANGGKYPYP-PGLLGFPGFLAQHPYILERRSSSKSPTPEPAQSPALRE 1214
            ..|:|......|||.|.:.|.....| .||.|          .|||..:|:...|..........
Human  1249 ANEISVIQNGGIPPIPGSLGSGNSSPVSGLTG----------NLERLQNSEPNAPLAGLEKMASS 1303

  Fly  1215 EEGS 1218
            |.|:
Human  1304 ENGT 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	15/21 (71%)
		C2H2 Zn finger	323..343	CDD:275368	14/19 (74%)
		zf-H2C2_2	335..360	CDD:290200	20/24 (83%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	11/19 (58%)
		zf-H2C2_2	595..620	CDD:290200	20/24 (83%)
		C2H2 Zn finger	611..631	CDD:275368	16/19 (84%)
		C2H2 Zn finger	643..663	CDD:275368	12/19 (63%)
		lambda-1	1013..>1061	CDD:212564	20/56 (36%)
		zf-C2H2	1040..1062	CDD:278523	14/21 (67%)
		C2H2 Zn finger	1042..1062	CDD:275368	13/19 (68%)
		zf-H2C2_2	1054..1079	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1070..1090	CDD:275368	15/19 (79%)
SALL1	NP_002959.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..102		3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..127		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..172		8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..336		4/18 (22%)
		C2H2 Zn finger	451..471	CDD:275368	14/19 (74%)
		zf-H2C2_2	463..488	CDD:290200	20/24 (83%)
		C2H2 Zn finger	479..499	CDD:275368	14/19 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..646		15/81 (19%)
		C2H2 Zn finger	708..728	CDD:275368	11/19 (58%)
		zf-H2C2_2	720..745	CDD:290200	20/24 (83%)
		C2H2 Zn finger	736..756	CDD:275368	16/19 (84%)
		zf-C2H2	766..788	CDD:278523	12/21 (57%)
		C2H2 Zn finger	768..788	CDD:275368	12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..856		16/77 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..963		13/68 (19%)
		C2H2 Zn finger	1003..1023	CDD:275370	7/20 (35%)
		zf-H2C2_2	1015..1040	CDD:290200	10/32 (31%)
		zf-C2H2	1029..1051	CDD:278523	3/21 (14%)
		C2H2 Zn finger	1031..1051	CDD:275370	3/19 (16%)
		lambda-1	1064..>1155	CDD:212564	29/124 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1095..1120		6/24 (25%)
		zf-C2H2	1134..1156	CDD:278523	14/21 (67%)
		C2H2 Zn finger	1136..1156	CDD:275368	13/19 (68%)
		zf-H2C2_2	1148..1173	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1164..1184	CDD:275368	15/19 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7769
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5659
OMA	1	1.010	-	-		QHG47594
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm40936
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.930