DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and SALL2

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_011535366.1	Gene:	SALL2 / 6297	HGNCID:	10526	Length:	1043	Species:	Homo sapiens

Alignment Length:	1250	Identity:	296/1250 - (23%)
Similarity:	431/1250 - (34%)	Gaps:	416/1250 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RERDRDTLLAKELDADSNNNGTEPQMEAEAVPESDTERET-----AEERGEEQEPENSNEALDLS 97
            :|...::..:.|...:.:||......|....|:|.:...|     .|.||||........|...:
Human    69 QENPNNSSASSEPRPEGHNNPQVMDTEHSNPPDSGSSVPTDPTWGPERRGEESSGHFLVAATGTA 133

  Fly    98 LISSGG--------------RESLP--------------GSGHVSLE-ALQHTKVAVAQFAATAM 133
            ....||              .||.|              ||||:::. .|:..:|
Human   134 AGGGGGLILASPKLGATPLPPESTPAPPPPPPPPPPPGVGSGHLNIPLILEELRV---------- 188

  Fly   134 AGNHQSADLAMVQSTIFNVQRQHLMQLQLIQHLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPK 198
                              :|::.:.|:|:.:.:..|:     ..||  |..........|...|.
Human   189 ------------------LQQRQIHQMQMTEQICRQV-----LLLG--SLGQTVGAPASPSELPG 228

  Fly   199 KQPTNGLKEELELEQGPESEQDQES-RREENSKTDKRGTEDRKA------EPEGYQSMMCDISSS 256
            ....:..|..|.|....:..|..:: ....:|.:...|.|..|.      .|.|.|....
Human   229 TGTASSTKPLLPLFSPIKPVQTSKTLASSSSSSSSSSGAETPKQAFFHLYHPLGSQHPFS----- 288

  Fly   257 LASSIITNHDPPPAPNEPNCLEMLQRRTEEVLDS------------ASQSLHAAQ-MQEEYSEYA 308
             |..:..:|.|.|||:     ..|...|::::.|            |:|.|.||: ::...|...
Human   289 -AGGVGRSHKPTPAPS-----PALPGSTDQLIASPHLAFPSTTGLLAAQCLGAARGLEATASPGL 347

  Fly   309 SKEAQSRGEIF-------------KHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTT 360
            .|.....||:.             :|:|::|.|:|||.|||||||||||||||:.|||||::|||
Human   348 LKPKNGSGELSYGEVMGPLEKPGGRHKCRFCAKVFGSDSALQIHLRSHTGERPYKCNVCGNRFTT 412

  Fly   361 KGNLKVHYQRHTQIFPPMLLPPGVAPN-----VGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQ 420
            :||||||:.||.:.:|.:.:.|...|.     :..||            ||:...|
Human   413 RGNLKVHFHRHREKYPHVQMNPHPVPEHLDYVITSSG------------LPYGMSV--------- 456

  Fly   421 NQVEEPEEIRQEIPVPQAEDLSKPMVKEKE--KSHSPVERVKTPKEVKTDAALPSSEK------- 476
                .||:..:|...|......||:|....  .:...:..:.|.....|...||:..|
Human   457 ----PPEKAEEEAATPGGGVERKPLVASTTALSATESLTLLSTSAGTATAPGLPAFNKFVLMKAV 517

  Fly   477 -PEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSL 540
             |:.:..:.....|..:......::|..:..|..:   ||..|....|:.....|..|.|..|.|
Human   518 EPKNKADENTPPGSEGSAISGVAESSTATRMQLSK---LVTSLPSWALLTNHFKSTGSFPFPYVL 579

  Fly   541 AQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENK------------------------LTDPN 581
            ..:..             ..||||||||||:.|:.:                        .:.||
Human   580 EPLGA-------------SPSETSKLQQLVEKIDRQGAVAVTSAASGAPTTSAPAPSSSASSGPN 631

  Fly   582 QCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVC 646
            ||:.|.:|:||..:|::|...|.|||||:||:|||||:|:|||:||...||..|..|:|..||:|
Human   632 QCVICLRVLSCPRALRLHYGQHGGERPFKCKVCGRAFSTRGNLRAHFVGHKASPAARAQNSCPIC 696

  Fly   647 HQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEA--ERLGIEDQNSNKSLGTSDTLDFSTTIS 709
            .:||:|.:.||||:|:|.     |||   ..|.|.|  |..|...:|.::.             |
Human   697 QKKFTNAVTLQQHVRMHL-----GGQ---IPNGGTALPEGGGAAQENGSEQ-------------S 740

  Fly   710 DHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSH 774
            ..||.||...|                      .:..|.|.|...:.|:|.:.....|.:||.|
Human   741 TVSGARSFPQQ----------------------QSQQPSPEEELSEEEEEEDEEEEEDVTDEDS- 782

  Fly   775 SNPDLTGGRSESGEMPAMDLSSPSSN-SGRIFATGLANGAAGGG----SGNGGLPMLGMPMPPNL 834
                |.|..||||...|:.:...|.. ||.....|....||..|    |.........:|.||
Human   783 ----LAGRGSESGGEKAISVRGDSEEASGAEEEVGTVAAAATAGKEMDSNEKTTQQSSLPPPP-- 841

  Fly   835 LLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEP 899
                                              ||.::
Human   842 ----------------------------------PPDSL-------------------------- 846

  Fly   900 ATGHAQRPQCSDAGSP--YGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIK 962
                 .:||..:.||.  .|.|                  ..|.| ||.|:.|..|..|
Human   847 -----DQPQPMEQGSSGVLGGK------------------EEGGK-PERSSSPASALTP------ 881

  Fly   963 EDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGP 1027
                             ||..|..|.                        ...|..|:| |...|
Human   882 -----------------EGEATSVTL------------------------VEELSLQEA-MRKEP 904

  Fly  1028 PTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKP-FQCNVCQKAFTTKGNLKVHMGTHM 1091
            ..||      ::..|.||.:.|.|.:||:.|.:||..:.| |.|..|::.|..:..||.||   :
Human   905 GESS------SRKACEVCGQAFPSQAALEEHQKTHPKEGPLFTCVFCRQGFLERATLKKHM---L 960

  Fly  1092 WTNPTSRRGRRMSLELPMRPGPNS---------------GQGH-----PGSSAEQEFMQRRPELF 1136
            ..:..::....:|..|||:|..:|               |.|.     |.:...:|..::...|.
Human   961 LAHHQNQYVAFLSNGLPMKPWNSSSTSTTTPSLAPPVLFGLGTVAGKVPPTMGSREAKEKTAPLL 1025

  Fly  1137 FPYLPPFFNGLPPKP 1151
            |.  ||....:|.||
Human  1026 FQ--PPAPKAVPEKP 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	15/21 (71%)
		C2H2 Zn finger	323..343	CDD:275368	14/19 (74%)
		zf-H2C2_2	335..360	CDD:290200	20/24 (83%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	595..620	CDD:290200	15/24 (63%)
		C2H2 Zn finger	611..631	CDD:275368	13/19 (68%)
		C2H2 Zn finger	643..663	CDD:275368	11/19 (58%)
		lambda-1	1013..>1061	CDD:212564	15/47 (32%)
		zf-C2H2	1040..1062	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1042..1062	CDD:275368	8/19 (42%)
		zf-H2C2_2	1054..1079	CDD:290200	10/25 (40%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/19 (37%)
SALL2	XP_011535366.1	C2H2 Zn finger	375..395	CDD:275368	14/19 (74%)
		zf-H2C2_2	387..412	CDD:290200	20/24 (83%)
		C2H2 Zn finger	403..423	CDD:275368	14/19 (74%)
		C2H2 Zn finger	633..653	CDD:275368	7/19 (37%)
		zf-H2C2_2	645..670	CDD:290200	15/24 (63%)
		C2H2 Zn finger	661..681	CDD:275368	13/19 (68%)
		zf-C2H2	692..713	CDD:278523	11/20 (55%)
		C2H2 Zn finger	693..713	CDD:275368	11/19 (58%)
		C2H2 Zn finger	913..933	CDD:275370	8/19 (42%)
		C2H2 Zn finger	942..959	CDD:275370	5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146364
Domainoid	1	1.000	90	1.000	Domainoid score	I7769
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40936
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8600
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.880