DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and sall4

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001074078.1	Gene:	sall4 / 572527	ZFINID:	ZDB-GENE-060328-2	Length:	1091	Species:	Danio rerio

Alignment Length:	1350	Identity:	363/1350 - (26%)
Similarity:	530/1350 - (39%)	Gaps:	482/1350 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ERERDRDRDRD----RDRD--------RERDRDTLLAKELDADSNN---NGTE--PQMEAEAVPE 70
            |.||:..:.:.    :|.|        .:|....:|:...|..:|:   :|.|  ..||.|.:..
Zfish    63 EHERNCTKSQQVVIMKDGDGSEVPPEFSQRSPGDVLSDPCDQSTNSYSKHGAESDEMMEGEFMLN 127

  Fly    71 SDTERETAEERGEEQEPENSNEALDLS---LISSGGRESLPGSGHVSLEALQHTKVAVAQFAATA 132
            .|             .|.|.::.:..|   :.||..::|     :|:||::..|||||.|.::.:
Zfish   128 QD-------------NPSNHDQEVSGSPGYVASSKLQDS-----NVTLESMAATKVAVTQHSSNS 174

  Fly   133 MAGN------HQSADLA--MVQSTIFNVQRQHLMQLQLIQ------------------------- 164
            .:..      ||...||  |:...:.::|:|.|.|:||.:
Zfish   175 SSQKSPPPQPHQDTLLAIPMILEQLVSLQQQQLQQIQLTEQIRIQVAMVAPPSLHAAVGAVMDPL 239

  Fly   165 -----HLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQDQESR 224
                 ||..||. |.||.:|:.:.|                      :.|.||...:::..| |.
Zfish   240 KALGAHLSQQLS-AAAALIGKRTGS----------------------QSLSLEALKQAKLPQ-SA 280

  Fly   225 REENSKTDKRGTEDRKAEPEGYQSMMCDISSSLASSIITNHDPPPAPNEPNCLEMLQRRTEEVLD 289
            ....|.....|:...|.:.:|    :.|::|.|         |...|..|..:.         |.
Zfish   281 TIPTSLPGGLGSIPLKPDLKG----LPDLASRL---------PALLPQSPGVIG---------LQ 323

  Fly   290 SASQSLHAAQMQEEYSEYASKEAQSRGEI-------------FKHRCKYCGKIFGSYSALQIHLR 341
            |...:| |..|.      .||:|:::|.:             |||:||:|||.||:.||||||||
Zfish   324 SPFNNL-ATSMD------PSKKAKTKGPVVSEPPKNVSVEHSFKHKCKFCGKTFGNDSALQIHLR 381

  Fly   342 SHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLP 406
            ||||||||.||:||::||||||||||:|||.:.:|.:.:.|...|
Zfish   382 SHTGERPFKCNICGNRFTTKGNLKVHFQRHKEKYPHIKMNPHPVP-------------------- 426

  Fly   407 FAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAED--------LSKPMVKEKEKSHSPVERVKTPK 463
                       :|.:.:.....|...:.||..|:        |..|........|.||.:...|.
Zfish   427 -----------EHLDNMPSNNGIPYGMSVPMEENGFSETKPVLGVPTTGPPAGPHPPVLQAFKPS 480

  Fly   464 EVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSS 528
            .....|..|.|::|....|.....||...|     |..|.|...:|....:|...||    ..:|
Zfish   481 FDIPAAGDPYSQRPSSSGSDGASISSGMFG-----QDIAGSDQSKDSPDAMVGLHHI----NGNS 536

  Fly   529 ASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCR 593
            .:.|:                          .|.|:||||:||.:|.:..|||:|:.|.:|:||:
Zfish   537 LTGEN--------------------------GSGTAKLQQMVDCLEKRTNDPNECVICHRVLSCQ 575

  Fly   594 SSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQ 658
            |||:||.||||||||::||||||||:||||||||..:|:...|::.|..||:||:||:|.::|||
Zfish   576 SSLKMHYRTHTGERPYKCKICGRAFSTKGNLKAHYGVHRANTPLKMQHSCPICHKKFTNAVVLQQ 640

  Fly   659 HIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGD 723
            |||:|     .||| .|                             :|.:.::..:..|:
Zfish   641 HIRMH-----MGGQ-IP-----------------------------NTPLPENQFESPEA----- 665

  Fly   724 FDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSNPDLTGGRSESGE 788
            .|..||.|.|.||..:..:.        .|:|.|.:.:.::.
Zfish   666 LDSSMTEDKTIDSNGHEESM--------EEQDFELDNQEKLN----------------------- 699

  Fly   789 MPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAK 853
                            ::||                    |.|       ..:::.        .
Zfish   700 ----------------YSTG--------------------PQP-------VTKDDQ--------T 713

  Fly   854 FPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHL-----------QSEHAKEPATG----- 902
            ||..|                    .|...:.|||:|:           ||..|.|..:|
Zfish   714 FPGQP--------------------SMFTGITALENHMKNLTSALNLQRQSSTASESDSGLKDSP 758

  Fly   903 ---------HAQRPQCSDAGSPYGAKLTLNP------NLFAKKPPSSSSSSSGEKLPESSNPPFP 952
                     :.:.|..||:.|.:    :|:|      |..:|.|.|::...|.:..|::..|...
Zfish   759 LGSGEVDYKNDRSPVVSDSVSFH----SLSPIDGPPSNGPSKSPESTNLDDSVKSRPDTDAPQDF 819

  Fly   953 AENPPA---------TPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAE-------QSL 1001
            :||..|         .||||:|         |.|...|           |.|.::       .||
Zfish   820 SENNGALDLTSSFTSKPIKEEP---------GLSFASG-----------EYGSSQLPFMRVPPSL 864

  Fly  1002 MKMQLH--------AHRFPASPLDFQQALMSAGPPTSSLDPPVNNK-HFCHVCRRNFSSSSALQI 1057
            :|:::.        ||...:|.|. |.|   |.||.||..|..:.| |.|::|.:||||:|||||
Zfish   865 VKLEMQIPPETPMGAHGLYSSQLP-QGA---ATPPASSSAPRRSTKQHLCNMCGKNFSSASALQI 925

  Fly  1058 HMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMR------------ 1110
            |.|||||:|||.|::|.:|||||||||||:|||||.| |:|||:|:||:.||.
Zfish   926 HERTHTGEKPFACSICGRAFTTKGNLKVHVGTHMWNN-TARRGQRLSLDNPMALMAMGNEPKMMP 989

  Fly  1111 ---PGPNSGQGHPGSSAEQEFMQRRPELFFPYLPPFFNGLPPKPGELSPGAFPNIPPP-----PF 1167
               |.|......|        :...|.::..|...|.|||..|..|:|......||.|     |.
Zfish   990 DMLPPPKDLIPPP--------INFDPSMWNQYAAAFTNGLTMKTNEISVIQNGGIPLPGSLGGPL 1046

  Fly  1168 --ANGGKYPYPPGLLGFPGFLAQHPYILERRSSSKSPTPEPAQSPALREE 1215
              :.||........:|.||.:|:    :|:..|...     |:.|...||
Zfish  1047 VGSTGGITKMESSQMGIPGTVAE----MEKNGSESI-----AKFPHFMEE 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	16/21 (76%)
		C2H2 Zn finger	323..343	CDD:275368	15/19 (79%)
		zf-H2C2_2	335..360	CDD:290200	20/24 (83%)
		C2H2 Zn finger	351..371	CDD:275368	15/19 (79%)
		C2H2 Zn finger	583..603	CDD:275368	11/19 (58%)
		zf-H2C2_2	595..620	CDD:290200	20/24 (83%)
		C2H2 Zn finger	611..631	CDD:275368	16/19 (84%)
		C2H2 Zn finger	643..663	CDD:275368	13/19 (68%)
		lambda-1	1013..>1061	CDD:212564	24/48 (50%)
		zf-C2H2	1040..1062	CDD:278523	14/21 (67%)
		C2H2 Zn finger	1042..1062	CDD:275368	13/19 (68%)
		zf-H2C2_2	1054..1079	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1070..1090	CDD:275368	14/19 (74%)
sall4	NP_001074078.1	zf-C2H2	361..383	CDD:278523	16/21 (76%)
		C2H2 Zn finger	363..383	CDD:275368	15/19 (79%)
		zf-H2C2_2	375..400	CDD:290200	20/24 (83%)
		C2H2 Zn finger	391..411	CDD:275368	15/19 (79%)
		C2H2 Zn finger	565..585	CDD:275368	11/19 (58%)
		zf-H2C2_2	577..602	CDD:290200	20/24 (83%)
		C2H2 Zn finger	593..613	CDD:275368	16/19 (84%)
		zf-C2H2	623..645	CDD:278523	13/21 (62%)
		C2H2 Zn finger	625..645	CDD:275368	13/19 (68%)
		lambda-1	882..>929	CDD:212564	24/50 (48%)
		C2H2 Zn finger	910..930	CDD:275368	13/19 (68%)
		zf-H2C2_2	922..947	CDD:290200	17/24 (71%)
		C2H2 Zn finger	938..958	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8331
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm24357
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23233
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8600
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.910