DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and sall3a

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_005157904.1	Gene:	sall3a / 560775	ZFINID:	ZDB-GENE-020228-4	Length:	1322	Species:	Danio rerio

Alignment Length:	1383	Identity:	395/1383 - (28%)
Similarity:	549/1383 - (39%)	Gaps:	393/1383 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 NNGTEPQMEAEAVPESDTERETAEERGEE----------QEPENSNEALDLSLISSGGRESLPGS 110
            :.|.|..:|:.||.|.:.|....|...|:          .||:.|...|:....|||...|:| |
Zfish   125 DEGAEMMLESGAVLEKEDEPMEVELSPEKPIDPDDPVTLAEPDISLPPLEDHKQSSGAGYSIP-S 188

  Fly   111 GHVSLEALQHTKVAVAQF---AATAMAGNHQSADLAMVQSTIFNVQRQHLMQLQLIQHLQSQL-- 170
            .:|:||.|..|:||||||   |..|:|....:..:.|:...:..:|:|.|.||:||:.::||:
Zfish   189 TNVTLETLHGTRVAVAQFSQGARGALASEVSTMAIPMILDQLMALQQQQLRQLKLIEQIRSQVAL 253

  Fly   171 ----KRAEAAALGRHSHS-DEEEEEPEPEPEPK-----------KQPTNGL--KEELELEQG--- 214
                ...:.|...:..|| :...:.|.....|.           ..|.|.|  ...|.::..
Zfish   254 INNQAPTQTAVSHKVDHSINAALQVPSSSSIPAMPGQLHLRGFITPPINQLHMNNSLNVQASVAV 318

  Fly   215 ------------PESEQDQESRREENSKTDKRGTEDRKAEPEGYQSMMCDISSSLASSIITNHDP 267
                        |...|...|..:.|...:..    ......|....|...|.|::||..|:...
Zfish   319 SSALDVACTSVPPAGGQLASSGMKSNIAINSL----YPTTSNGVSPQMPPCSVSISSSSCTSSST 379

  Fly   268 PPAPNEPNCLEMLQRRTEEVL------------------DSASQSL------------------- 295
            ... .|.||...|.|.|...|                  .|:|.|:
Zfish   380 GTG-GEINCGISLPRNTPSPLTLTHGRLLTSPSSLPLVPHSSSNSVIFPNPLASIAATTNALDPL 443

  Fly   296 -----HAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCG 355
                 |........|.:.:|.: |....|||:|::|.|:|||.||||||||||||||||.||:||
Zfish   444 SALMKHRKAKPPNVSVFDTKPS-SEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICG 507

  Fly   356 SKFTTKGNLKVHYQRHTQIFPPMLLPPGVAP----NVGHSGQGQVQGEQYPIRLPFA-------- 408
            ::|:||||||||:|||.:.:|.:.:.|...|    ||..| .|...|...|...|..
Zfish   508 NRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTS-SGIPYGMSLPPEKPVTTWLDSKPI 571

  Fly   409 ------------PPVAPVGQEQHQNQVE-EPEEIRQEIPVPQAED---------LSKPMVKEKEK 451
                        ||..|...|.:.:... .|.....:.|.|.:.:         :::..:.:...
Zfish   572 LPTIPTSVALQLPPTIPSIIESYGDSTSFSPLNRSPQRPSPPSSECTSLSPNHLITETSIAQISS 636

  Fly   452 SHSPVERVKTPKEVKTDAA-LP--SSEKP----------EKEISKPVVT---SSRRNGSVRKRQT 500
            |..|.....||..:|.:|. ||  |:.:|          .:.||..:||   |:|...:.....:
Zfish   637 SPQPNLASNTPPVLKPEALHLPPNSTTRPGETSISTTSISQVISTTIVTTTCSTRTQLTDPVNSS 701

  Fly   501 SAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSK 565
            ||||.|.          |.|        :|.:.:|            ...:..|::..:||||||
Zfish   702 SAVSHPS----------LQI--------SSNQFKP------------KFPFGGLLDSMQTSETSK 736

  Fly   566 LQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSI 630
            |||||:||:.|:||||||:.|.:|:||:|:|:||.|.|||||||:||||||||.||||||.|..:
Zfish   737 LQQLVENIDKKMTDPNQCVICHRVLSCQSALKMHYRIHTGERPFKCKICGRAFTTKGNLKTHFGV 801

  Fly   631 HKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKS 695
            |:.|||:|.|..||:|.:||:|.::||||||:|     .|||......|
Zfish   802 HRSKPPLRVQHSCPICQKKFTNAVVLQQHIRMH-----MGGQIPNTPLP---------------- 845

  Fly   696 LGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKER 760
                ||  |..|.:|.|           ||| .::|:..:..|.          |..|.|:..|.
Zfish   846 ----DT--FQDTDADLS-----------FDE-KSLDAMSNYDDE----------LIDEMDQALED 882

  Fly   761 ERRIPNDCSDERSHSNPDLTGGRSESGEMPA------------MDLSSPSSNSGRIFATGLANGA 813
            |..:.::..|  .|....|....|.|...|.            |.||.|:.|....|:.......
Zfish   883 ETGLKDENMD--LHKQLHLYSEMSPSTSPPTSLISSIGAFENEMKLSDPAVNITHSFSVKPTENG 945

  Fly   814 AGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCF 878
            :|....||       .|..|.|.......|.|::|
Zfish   946 SGVDGVNG-------DMLKNDLSSTLVDLENHSVG------------------------------ 973

  Fly   879 KMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYGAKLTLNPNL-----FAKKPPSSSSSS 938
                      |..|||.:                    |:.|.|:|..     ...|.|.::|||
Zfish   974 ----------SPAQSESS--------------------GSMLALSPTYSQSESHRSKSPQANSSS 1008

  Fly   939 SGEKL------------------PESSNP---PFPAENPPATPIKEDPDQEQLMVEEGASAGEGS 982
            ..|.|                  |.|.|.   ...|..|..:.:|::.....|.:      |...
Zfish  1009 KDEALTSTSAHAMVKSEQLDIHSPGSENTGALDLTATQPTRSFVKDENPFSLLFL------GRDR 1067

  Fly   983 GTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGP--PTSS------------LD 1033
            |....||.     .:|.|.:|.: :.|..|  |...:...:..||  ||::            |.
Zfish  1068 GLSTPSNI-----SSESSTVKFE-NGHSKP--PALCEGPHLPVGPQVPTATAQTTISSNITPMLA 1124

  Fly  1034 PP----VNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTN 1094
            ||    ...:|.||.|.:||||:||||||.|||||:|||.|::|.:|||||||||||||||||.|
Zfish  1125 PPPPRRTPKQHNCHSCGKNFSSASALQIHERTHTGEKPFGCSICGRAFTTKGNLKVHMGTHMWNN 1189

  Fly  1095 PTSRRGRRMSLELPMRPGPNSGQGHPGSSAEQEFMQRR-----PELFFPYLPPFFNGLPPKPGEL 1154
            ..:|||||:|:|.||  ....|.....|...|:.:..|     |..:..|.....:||..|..|:
Zfish  1190 APARRGRRLSVENPM--ALLGGDAIKFSEMFQKDLAARAINVDPGFWNQYAVAITSGLAMKNNEI 1252

  Fly  1155 S---PGAFPNIPPPPFANGGKYPYPPGLLGFPGFLAQHPYILERRSSSKSPTPEPAQSPALREEE 1216
            |   .|..|:||..  .:||..|...|:.|.          :||..:..||.....:...|  |.
Zfish  1253 SVIQNGGIPSIPIS--LSGGGIPAVGGMSGG----------IERSRTGSSPPVTGLEKTNL--EM 1303

  Fly  1217 GSGNIWHPLSRIKVENNQ 1234
            |:|   ||.||.:.|:.:
Zfish  1304 GTG---HPFSRFREEDKE 1318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	15/21 (71%)
		C2H2 Zn finger	323..343	CDD:275368	14/19 (74%)
		zf-H2C2_2	335..360	CDD:290200	20/24 (83%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	10/19 (53%)
		zf-H2C2_2	595..620	CDD:290200	19/24 (79%)
		C2H2 Zn finger	611..631	CDD:275368	15/19 (79%)
		C2H2 Zn finger	643..663	CDD:275368	12/19 (63%)
		lambda-1	1013..>1061	CDD:212564	22/65 (34%)
		zf-C2H2	1040..1062	CDD:278523	15/21 (71%)
		C2H2 Zn finger	1042..1062	CDD:275368	14/19 (74%)
		zf-H2C2_2	1054..1079	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1070..1090	CDD:275368	15/19 (79%)
sall3a	XP_005157904.1	PHA03169	<29..>190	CDD:223003	19/65 (29%)
		COG5048	461..>787	CDD:227381	126/357 (35%)
		C2H2 Zn finger	475..495	CDD:275368	14/19 (74%)
		C2H2 Zn finger	503..523	CDD:275368	14/19 (74%)
		C2H2 Zn finger	754..774	CDD:275368	10/19 (53%)
		zf-H2C2_2	766..791	CDD:316026	19/24 (79%)
		C2H2 Zn finger	782..802	CDD:275368	15/19 (79%)
		zf-C2H2	812..834	CDD:306579	12/21 (57%)
		C2H2 Zn finger	814..834	CDD:275368	12/19 (63%)
		zf-C2H2	1135..1157	CDD:306579	15/21 (71%)
		C2H2 Zn finger	1137..1157	CDD:275368	14/19 (74%)
		zf-H2C2_2	1149..1174	CDD:316026	17/24 (71%)
		C2H2 Zn finger	1165..1185	CDD:275368	15/19 (79%)
		zf-C2H2	1165..1185	CDD:306579	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8331
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47594
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm24357
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.890