DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and znf983

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001121715.1	Gene:	znf983 / 560276	ZFINID:	ZDB-GENE-060503-812	Length:	715	Species:	Danio rerio

Alignment Length:	870	Identity:	181/870 - (20%)
Similarity:	276/870 - (31%)	Gaps:	294/870 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 PNCLEMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGE---------IFKHRCKYCGKI 329
            |....:.|..|||::|...:|....:.:|::...:.::.||..|         :....|..|||.
Zfish     4 PEPCRIKQEDTEELIDVKEESEELNEDEEKHQVKSEEKTQSETEQSISVKATAVNSLTCTQCGKS 68

  Fly   330 FGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPN------- 387
            |...|.|..|:|.||||:||.|..|..:|.:..|||.|.:.||          |..|:
Zfish    69 FTRKSGLNDHMRIHTGEKPFKCPHCDWRFNSLRNLKSHIRLHT----------GEKPHQCSHCSK 123

  Fly   388 -VGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEK 451
             ..||||                                   ::..:.:...|   ||.    |.
Zfish   124 RFNHSGQ-----------------------------------LKSHLRIHTGE---KPF----EC 146

  Fly   452 SHSPVERVKTPKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVE 516
            ||.. :|....|.:|....:.:.|||....:..:..|..  .|::|...:..:...::...:|.|
Zfish   147 SHCG-KRFSVSKNMKAHERIHTEEKPYHCTACGMTFSYL--SSLQKHTLNCQNVTVKEESEELNE 208

  Fly   517 HLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPN 581
            .:        .|..:.....|:|::.....:: ||
Zfish   209 DV--------KSEEKTQSETEHSISVKGTAVN-SW------------------------------ 234

  Fly   582 QCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVC 646
            .|..|.|.:||:|:|..|:|.||||:|::|..||:.|:....||:|..||..:.|    ::|..|
Zfish   235 TCTQCGKSLSCKSALNTHMRIHTGEKPYQCSHCGKRFSNSAYLKSHKRIHTEEKP----YQCSHC 295

  Fly   647 HQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDH 711
            .::||....|:.|:|.||           ...|......|       ||.
Zfish   296 DKRFSFSQNLKTHLRTHT-----------GEKPYHCTACG-------KSF--------------- 327

  Fly   712 SGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSN 776
                                     |..||..|.|                         |:|.|
Zfish   328 -------------------------RHMSSLQTHT-------------------------RNHHN 342

  Fly   777 PDLTGGR-SESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAA 840
            ..:.|.. .|...:.:...:...:..|:.|
Zfish   343 VMVEGSEDKEKHHVTSKQKTFNCTECGKSF----------------------------------- 372

  Fly   841 REEMHALGHAHAKFPLLPFGPLGFMGLH--PPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGH 903
            :.:.|.:.|               :.:|  ..|..|:.|.|........::| :..|..|
Zfish   373 KRKYHLIFH---------------LKIHSGENPYKCSHCDKRFRCTNVRKAH-EMIHTGE----- 416

  Fly   904 AQRPQCSDAGSP--YGAKLTLNPNLFAKKPPSSSS-------SSSGEKLPE---SSNPPFPAENP 956
             :..:||.....  |...|.::......:.|...|       ||||:|:.|   :...|||....
Zfish   417 -ELYKCSHCNKTFRYSGLLKVHERTHTGEKPYKCSHCEKRFRSSSGKKVHERTHTGEKPFPCSRC 480

  Fly   957 PATPIKEDPDQEQLMVEEGASAGE--------GSGTGATSNYPQEAGDAEQSLMKMQLHA----- 1008
            .    |...|..||:..|....||        |.....:|.......:......||..|:
Zfish   481 K----KRFRDSRQLIKHERVHTGEKPYPCNACGKRFRQSSTLRAHTVNIHNVKEKMDNHSIHTTE 541

  Fly  1009 --HRFPASPLDF-QQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQC 1070
              |........| .|:.::|.......:.|..    |..|.|:|..||.|..||.||||:||.:|
Zfish   542 KLHLCSECGKSFATQSYLNAHQKIHFGEKPFT----CTQCGRSFRYSSQLNEHMMTHTGEKPHEC 602

  Fly  1071 NVCQKAFTTKGNLKVHMGTHMWTNP 1095
            :.|.|.|....|||||.|.|....|
Zfish   603 DQCGKRFLKASNLKVHFGVHTKEKP 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	9/21 (43%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	12/24 (50%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	9/19 (47%)
		zf-H2C2_2	595..620	CDD:290200	12/24 (50%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	13/48 (27%)
		zf-C2H2	1040..1062	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1042..1062	CDD:275368	9/19 (47%)
		zf-H2C2_2	1054..1079	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1070..1090	CDD:275368	10/19 (53%)
znf983	NP_001121715.1	C2H2 Zn finger	62..82	CDD:275368	9/19 (47%)
		COG5048	86..521	CDD:227381	122/676 (18%)
		C2H2 Zn finger	90..110	CDD:275368	7/19 (37%)
		zf-H2C2_2	102..127	CDD:290200	8/34 (24%)
		C2H2 Zn finger	118..138	CDD:275368	4/54 (7%)
		zf-H2C2_2	131..154	CDD:290200	7/30 (23%)
		C2H2 Zn finger	146..166	CDD:275368	5/20 (25%)
		C2H2 Zn finger	174..190	CDD:275368	2/17 (12%)
		C2H2 Zn finger	236..256	CDD:275368	9/19 (47%)
		zf-H2C2_2	248..273	CDD:290200	12/24 (50%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-H2C2_2	276..300	CDD:290200	8/27 (30%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	304..329	CDD:290200	9/82 (11%)
		C2H2 Zn finger	320..340	CDD:275368	9/91 (10%)
		C2H2 Zn finger	367..385	CDD:275368	4/67 (6%)
		C2H2 Zn finger	393..413	CDD:275368	4/20 (20%)
		C2H2 Zn finger	421..441	CDD:275368	4/19 (21%)
		zf-H2C2_2	434..458	CDD:290200	3/23 (13%)
		C2H2 Zn finger	449..469	CDD:275368	7/19 (37%)
		C2H2 Zn finger	477..497	CDD:275368	5/23 (22%)
		C2H2 Zn finger	505..526	CDD:275368	2/20 (10%)
		C2H2 Zn finger	546..566	CDD:275368	3/19 (16%)
		C2H2 Zn finger	574..594	CDD:275368	9/19 (47%)
		C2H2 Zn finger	602..622	CDD:275368	10/19 (53%)
		zf-H2C2_2	614..639	CDD:290200	8/14 (57%)
		C2H2 Zn finger	630..650	CDD:275368
		C2H2 Zn finger	658..678	CDD:275368
		zf-H2C2_2	670..695	CDD:290200
		C2H2 Zn finger	686..706	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910