DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and sall1a

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001139486.1	Gene:	sall1a / 555721	ZFINID:	ZDB-GENE-020228-2	Length:	1313	Species:	Danio rerio

Alignment Length:	1430	Identity:	393/1430 - (27%)
Similarity:	576/1430 - (40%)	Gaps:	401/1430 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GTRS-GSGERERDRD-RDRDRDRDRERDRDTLLAKELDADSNNNGTEPQMEAEAVPESD------ 72
            ||.| ||.....|.. .|...:.|:....|.|....||.:   ...:.:|...:.|.:|
Zfish    82 GTFSPGSSPHNPDEQMNDTTNNTDQAELTDLLEQNILDKE---EAMDTEMSGVSAPHNDGNGRMA 143

  Fly    73 ---------TERETAEERGEEQEPENSNEALDLSLISSGGRESLPGSG-------------HVSL 115
                     |...|....|       ||  |..|:||:    |||..|             :|.:
Zfish   144 GSSPLSGVGTGHGTLGSTG-------SN--LGSSVISA----SLPQLGNLTELGNFSMINSNVII 195

  Fly   116 EALQHTKVAVAQFAATAMAGNHQSADLAMVQSTIFNVQRQHLMQLQLIQHLQSQLKRAEAAALGR 180
            |.||.||||||||:....|...|...:..:...:..:|:|.:.|||||:.::.|:       |..
Zfish   196 ENLQSTKVAVAQFSQETRATGGQRVAVPALMEQLLALQQQQIHQLQLIEQIRHQI-------LLL 253

  Fly   181 HSHSDEEEEEPEPEP-------------------------------EPKKQPTNGLKEELELEQG 214
            .|.|.|.:..|...|                               ..:....:.||:...:.|.
Zfish   254 ASQSPELQAPPSSSPVTLGSGTSPLTTLSSHLSQQLAAAAGLAQSIASQSASISSLKQMANVAQL 318

  Fly   215 PES-----EQDQESRREENSKTDKRGTEDRKAE------PEGYQSM---------MCDISSSLAS 259
            |:|     |..|.......:..:.:..|.|...      |.|..|:         |.::.:.:|:
Zfish   319 PQSNSSVGESSQSLAAPGPAPVNAQPLEKRPGNAGSLHPPLGNPSLAKSSTPAFAMGNLLNPVAN 383

  Fly   260 SIITNHDPPPAPNEPNCLEMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGE--IFKHR 322
            :::    |.|.|..|.....|......|.|..|.:..|.|.:.:....:|.|.:|..|  .|||:
Zfish   384 TLL----PQPPPGNPIFSSALPSVGSTVEDLNSLAALAQQRKGKPPNVSSFEPKSSSEDTFFKHK 444

  Fly   323 CKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAP- 386
            |::|||:|||.|||||||||||||||:.||:||::|:|:||||||:|||.:.:|.:.:.|...|
Zfish   445 CRFCGKVFGSDSALQIHLRSHTGERPYKCNICGNRFSTRGNLKVHFQRHKEKYPHIQMNPYPVPE 509

  Fly   387 ---NVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKE 448
               |:..|     .|..|.:.:|                   ||:     ||....| |||::..
Zfish   510 HLDNIPTS-----TGIPYGMSMP-------------------PEK-----PVTSWLD-SKPVLST 544

  Fly   449 KEKSHSPVERVKTP-------KEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPP 506
            ...|...:.....|       ||.....|:.|.....|..|.|..|..:...||.:...|...|.
Zfish   545 LTSSVGMLLPPTIPSLPPFIKKEENNSLAISSPSHSAKSDSGPADTPMKNTDSVLEEGESTTLPT 609

  Fly   507 QEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQ--------MERIIDKSWE------DLIEI 557
            ...:..   |:...:.|:...|::.|. ..||:.:.        :..::.:.::      .|::.
Zfish   610 SNGKAE---ENNQSSNLLSNMSSAVEG-TIEYTTSNSPPMATNPLMPLMSEQFKAKFPFGGLLDP 670

  Fly   558 DKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKG 622
            .:.||||||||||:||:.|:.|||:|:.|.:::||:|:|:||.|||||||||:||:|||||.|||
Zfish   671 LQGSETSKLQQLVENIDRKVADPNECVICHRILSCQSALKMHYRTHTGERPFKCKVCGRAFTTKG 735

  Fly   623 NLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGI 687
            |||.|.|:|:..||:|.|..||:|.:||:|.::||||||:|     .|||......|
Zfish   736 NLKTHYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMH-----MGGQIPNTPLP-------- 787

  Fly   688 EDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNS---------SAA 743
              .|..:|:|                     |..|.||| ..:|..|:..|::         |:.
Zfish   788 --DNYPESMG---------------------SDAGSFDE-RNIDDLDNFSDDNMEGIEDGPDSSI 828

  Fly   744 TATPHPLERERDR--------------EKERERRIPNDCSDERSHSNPDLTGGRS-ESGEMPAMD 793
            ..||..::..:|.              |:.:|:...:...:|..:..     |:| |:|.:....
Zfish   829 PDTPKSVDASQDSLCSSPTLHESFGMDERIQEKSANHGAGEEVQYDQ-----GKSVENGLVEGDR 888

  Fly   794 LSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLM-------------AAAREEMH 845
            .::.||:.|    ..:.:.:||..:.:.....:..|.|.|.:..             |.:.|.:.
Zfish   889 FTNDSSSLG----GDIESQSAGSPAVSESTSSMQAPSPSNGIFQQQKSPSMEDRQQRALSLEHIS 949

  Fly   846 A-LGHAHAKFP-----------------LLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQ 892
            | |.|:::..|                 |.||...|.:    ....|::|.|.....:||:.|.:
Zfish   950 ASLMHSNSASPGALDLTSVNSSKDPISMLFPFRERGTL----KNTACDICGKTFACQSALDIHYR 1010

  Fly   893 SEHAKEPATGHAQRP-QCSDAGSPYGAKLTLNPNLFAKK---------PPSSSSSSSGEKLPESS 947
            | |.||       || .|:.....:..|..|..::...:         .|::|.:||   |..|.
Zfish  1011 S-HTKE-------RPFICTVCNRGFSTKGNLKQHMLTHQMRDLPSQLFEPNTSLASS---LASSP 1064

  Fly   948 NPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHA--HR 1010
            .|...:..|.:                                         |:||.:::.  |.
Zfish  1065 TPSLLSVGPLS-----------------------------------------SMMKTEVNGFLHG 1088

  Fly  1011 FPASPLDFQQALMSAGPPTS---SLDPP--VNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQC 1070
            ......|...||:::...||   |..||  ...:|||..|.:.||||||||||.|||||:|||.|
Zfish  1089 LQPEVKDLPPALVTSSASTSPVLSAAPPRRTPKQHFCTTCGKTFSSSSALQIHERTHTGEKPFAC 1153

  Fly  1071 NVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMR-PGPN---------------SGQGH 1119
            .:|.:|||||||||||||||||.:..:|||||:|::.||. .|.|               :|.|.
Zfish  1154 TICGRAFTTKGNLKVHMGTHMWNSAPARRGRRLSVDGPMAFLGTNPVKFPELFQKDLSSRAGNGD 1218

  Fly  1120 PGSSAEQEFMQRRPELFFPYLPPFFNGLPPKPGELSPGAFPNIPPP---PFANGGKYPYPPGLLG 1181
            |.|...|            |...|.|||..|..|:|......:|||   ...|||..|. .||.|
Zfish  1219 PTSFWNQ------------YAAAFSNGLAMKTNEISVIQNGGLPPPLSGSVGNGGSSPI-GGLTG 1270

  Fly  1182 FPGFLAQHPYILERRSSSKSPTPEPAQSPALREEEGSGNIWHPLSRIKVENNQNESMGGFNEQED 1246
                           |..|....||  :|||...|...|         .||..:.....|.|.::
Zfish  1271 ---------------SMEKLHNSEP--NPALAGLEKMAN---------TENGTHFRFTRFMEDKE 1309

Fly 1247 1246
Zfish 1310 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	16/21 (76%)
		C2H2 Zn finger	323..343	CDD:275368	15/19 (79%)
		zf-H2C2_2	335..360	CDD:290200	19/24 (79%)
		C2H2 Zn finger	351..371	CDD:275368	13/19 (68%)
		C2H2 Zn finger	583..603	CDD:275368	9/19 (47%)
		zf-H2C2_2	595..620	CDD:290200	19/24 (79%)
		C2H2 Zn finger	611..631	CDD:275368	15/19 (79%)
		C2H2 Zn finger	643..663	CDD:275368	12/19 (63%)
		lambda-1	1013..>1061	CDD:212564	22/52 (42%)
		zf-C2H2	1040..1062	CDD:278523	15/21 (71%)
		C2H2 Zn finger	1042..1062	CDD:275368	13/19 (68%)
		zf-H2C2_2	1054..1079	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1070..1090	CDD:275368	15/19 (79%)
sall1a	NP_001139486.1	ZnF_C2H2	443..465	CDD:197676	16/21 (76%)
		C2H2 Zn finger	445..465	CDD:275368	15/19 (79%)
		zf-H2C2_2	457..482	CDD:290200	19/24 (79%)
		C2H2 Zn finger	473..493	CDD:275368	13/19 (68%)
		C2H2 Zn finger	696..716	CDD:275368	9/19 (47%)
		zf-H2C2_2	708..733	CDD:290200	19/24 (79%)
		C2H2 Zn finger	724..744	CDD:275368	15/19 (79%)
		zf-C2H2	754..776	CDD:278523	12/21 (57%)
		C2H2 Zn finger	756..776	CDD:275368	12/19 (63%)
		C2H2 Zn finger	992..1012	CDD:275370	7/20 (35%)
		zf-H2C2_2	1004..1029	CDD:290200	10/32 (31%)
		zf-C2H2	1018..1040	CDD:278523	3/21 (14%)
		C2H2 Zn finger	1020..1040	CDD:275370	3/19 (16%)
		zf-C2H2	1123..1145	CDD:278523	15/21 (71%)
		C2H2 Zn finger	1125..1145	CDD:275368	13/19 (68%)
		zf-H2C2_2	1137..1162	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1153..1173	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8331
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47594
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm24357
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.980