DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and znf568

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001016087.1	Gene:	znf568 / 548841	XenbaseID:	XB-GENE-5723274	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	832	Identity:	160/832 - (19%)
Similarity:	222/832 - (26%)	Gaps:	411/832 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 YASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRH 371
            :...|..|..:.||  |..|||.|...:.|..|.:.||||:||.|:.||..||.|.:|:.|.:.|
Frog     5 HPQSELHSAAKKFK--CPECGKRFLRKNELNTHWKFHTGEKPFTCSECGKSFTLKASLQNHLRIH 67

  Fly   372 TQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVP 436
            |                         ||:     |:.
Frog    68 T-------------------------GEK-----PYT---------------------------- 74

  Fly   437 QAEDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPSSEKPE--KEISKPVVTSSRRNGSVRKRQ 499
                     ..|..||.|.:...:..:.:.|      .|||.  .|..|...||.
Frog    75 ---------CTECGKSFSDIGDFRKHQRIHT------GEKPYACSECGKKFTTSG---------- 114

  Fly   500 TSAVSPPQEDRERDLVEHLHI---AKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTS 561
                         :|::|.|:   ||
Frog   115 -------------NLLQHQHVHTGAK--------------------------------------- 127

  Fly   562 ETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKA 626
                              |..|..|.|..:|.|.|.:|:||||||:||.|..||:.|..|..|:.
Frog   128 ------------------PFTCRECGKSFTCSSHLSIHVRTHTGEKPFSCAECGKCFKVKSYLRI 174

  Fly   627 HMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQN 691
            |.:.|..:.|    |.|..|.:.||....|..|.|:||               ||..
Frog   175 HQTTHTGEKP----FTCTECGKGFSAKSGLLTHQRLHT---------------GEKR-------- 212

  Fly   692 SNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDR 756
                        ||.|
Frog   213 ------------FSCT------------------------------------------------- 216

  Fly   757 EKERERRIPNDCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNG 821
                      :|....:|.|..:...|..:||.|     ...:..|:.|.|
Frog   217 ----------ECGKRFTHKNTLVLHERFHTGEKP-----FTCTECGKGFIT-------------- 252

  Fly   822 GLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAA 886
                             .:..:.|...|...|    ||.             |..|.|:..|...
Frog   253 -----------------VSFLKTHQKVHTGEK----PFS-------------CTECGKIFTSKKG 283

  Fly   887 LESHLQSEHAKEPAT-----------GHAQRPQ----------CSDAGSPYGAKLTLNPNLFAKK 930
            |..||::...::|.|           .|.:..|          |::....|..|.:|..:|
Frog   284 LNLHLRTHTGEKPFTCTECGKSFSCKSHLRSHQNVHTRSKVFKCTECDKCYATKQSLEYHL---- 344

  Fly   931 PPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAG 995
                 |:.:||:       |||.                      ...|:|        :|....
Frog   345 -----SAHTGER-------PFPC----------------------TECGKG--------FPNRHV 367

  Fly   996 DAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMR 1060
            ..:.:|    :|.|..|.:                           |..|.:.|||.|.|..|.|
Frog   368 LQKHTL----IHLHLKPFT---------------------------CGECEKCFSSKSHLNRHQR 401

  Fly  1061 THTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNP--TSRRGRRMSLELPMR 1110
            .|||:|||.|..|.|.|..|.:||.||..|....|  .:..|:....|..:|
Frog   402 VHTGEKPFTCTECGKGFFHKNHLKRHMIIHTGEKPFTCTECGKTFPYEKSLR 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	7/21 (33%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..360	CDD:290200	12/24 (50%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	595..620	CDD:290200	14/24 (58%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	8/47 (17%)
		zf-C2H2	1040..1062	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1042..1062	CDD:275368	9/19 (47%)
		zf-H2C2_2	1054..1079	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1070..1090	CDD:275368	9/19 (47%)
znf568	NP_001016087.1	C2H2 Zn finger	19..39	CDD:275368	7/19 (37%)
		C2H2 Zn finger	47..67	CDD:275368	8/19 (42%)
		zf-H2C2_2	59..83	CDD:290200	10/90 (11%)
		C2H2 Zn finger	75..95	CDD:275368	4/19 (21%)
		zf-H2C2_2	87..112	CDD:290200	6/30 (20%)
		COG5048	99..485	CDD:227381	124/663 (19%)
		C2H2 Zn finger	103..123	CDD:275368	7/42 (17%)
		C2H2 Zn finger	131..151	CDD:275368	8/19 (42%)
		C2H2 Zn finger	159..179	CDD:275368	7/19 (37%)
		C2H2 Zn finger	187..207	CDD:275368	7/19 (37%)
		C2H2 Zn finger	215..235	CDD:275368	5/78 (6%)
		C2H2 Zn finger	243..263	CDD:275368	4/50 (8%)
		C2H2 Zn finger	271..291	CDD:275368	7/19 (37%)
		zf-H2C2_2	284..308	CDD:290200	5/23 (22%)
		C2H2 Zn finger	299..319	CDD:275368	2/19 (11%)
		C2H2 Zn finger	327..347	CDD:275368	6/28 (21%)
		C2H2 Zn finger	355..375	CDD:275368	4/53 (8%)
		C2H2 Zn finger	383..403	CDD:275368	9/19 (47%)
		zf-H2C2_2	395..418	CDD:290200	12/22 (55%)
		C2H2 Zn finger	411..431	CDD:275368	9/19 (47%)
		zf-H2C2_2	423..446	CDD:290200	7/22 (32%)
		C2H2 Zn finger	439..459	CDD:275368	3/15 (20%)
		zf-H2C2_2	451..476	CDD:290200	1/3 (33%)
		C2H2 Zn finger	467..487	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910