DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and ZNF107

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	878	Identity:	183/878 - (20%)
Similarity:	289/878 - (32%)	Gaps:	253/878 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 EVLDSASQSLHAAQMQEEYSEYASKEAQSR----GEIFKHR----------CKYCGKIFGSYSAL 336
            :|.|..|.|....:.......:..||....    .::.:||          |:.|||.|..:|.|
Human   196 KVFDKFSNSNRYKRRHTGNKHFKCKECSKSFCVLSQLTQHRRIHTRVNSYKCEECGKAFNWFSTL 260

  Fly   337 QIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVA---------PNVGHSG 392
            ..|.|.||||:|:.|..||..|.....|..|...||:..|......|.|         ..:.|:|
Human   261 TKHKRIHTGEKPYKCEECGKAFNQSSQLTRHKIIHTEEKPNKCEECGKAFKQASHLTIHKIIHTG 325

  Fly   393 QGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVE 457
            :                  .|...|:......:...:..:..:...|:|.|  .||..|:.:...
Human   326 E------------------KPYKYEECGKVFSQSSHLTTQKILHTGENLYK--CKECGKAFNLFS 370

  Fly   458 RVKTPKEVKTDAALPSSEKPE--KEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHI 520
            .:...|.:.      :.|||.  ||..:....||..| ...|..|.......|:.::.....|
Human   371 NLTNHKRIH------AGEKPYKCKECGRAFNISSNLN-KQEKIHTGGKLNKCEECDKAFNRSL-- 426

  Fly   521 AKLVRRSSASRESQP----------AEYSLAQMERII---DKSWEDLIEIDKTSETSKLQQLVDN 572
             ||........|.:|          .::|.....:||   :|.:       |..|..|    ..|
Human   427 -KLTAHKKILMEEKPYKCEECGKVFNQFSTLTRHKIIHTGEKPY-------KCKECGK----AFN 479

  Fly   573 IENKLTDPN---------QCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHM 628
            ..:.||:..         :|..|.|..:..|:|..|.:.::||:|::|:.||:||.....|..|.
Human   480 QSSNLTEHKKIHTAEKSYKCEECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTRHK 544

  Fly   629 SIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSN 693
            .||..:.|    :||..|.:.||....|.:|.:|||           ...|.:.|..|
Human   545 KIHTGEKP----YKCEECDRAFSQSSNLTEHKKIHT-----------GEKPYKCEECG------- 587

  Fly   694 KSLGTSDTLDFSTTISDHSGQRSESSQ--GGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDR 756
            |:.....||.....|  |:|::....:  |..|::...:               |.|.:...:::
Human   588 KAFNRFSTLTKHKRI--HTGEKPYKCEECGKAFNQSYQL---------------TRHKIVHTKEK 635

  Fly   757 EKERERRIPNDCSD------ERSHSNPDLTGGRS-----ESGEMPAM-----DLSSPSSN--SGR 803
                    .|.|.:      :.||        |:     .:||.|..     .:.:.|||  :.:
Human   636 --------LNKCEEFGKAFKQSSH--------RTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQK 684

  Fly   804 IFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLH 868
            |..||                       .||.     :.|.|  |.|...|..:....:.:.|
Human   685 IIHTG-----------------------ENLY-----KFEEH--GKAFNLFSNITNHKIIYTG-- 717

  Fly   869 PPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRP-QCSDAGSPYGAKLTLNPNLFAKKPP 932
            ..|:.|..|.|.....:.|..|      |...||  ::| ||::.|..:....|||.:...
Human   718 EKPHKCEECGKAYNRFSNLTIH------KRIHTG--EKPYQCAECGKAFNCSSTLNRHKII---- 770

  Fly   933 SSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDA 997
                 .:|||                 |.|.....:...:....:|.:...||......:|.|.|
Human   771 -----HTGEK-----------------PYKCKECGKAFNLSSTLTAHKKIHTGEKPYKCEECGKA 813

  Fly   998 EQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTH 1062
            ......:..|            :.:.::..|           :.|..|.::|:..|:|.||...|
Human   814 FNQSSNLTTH------------KKIHTSEKP-----------YKCEECGKSFNQFSSLNIHKIIH 855

  Fly  1063 TGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNP 1095
            ||:||::|....:||....||..|...|....|
Human   856 TGEKPYKCGDYGRAFNLSSNLTTHKKIHTGEKP 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	11/31 (35%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	12/24 (50%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	595..620	CDD:290200	10/24 (42%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	643..663	CDD:275368	6/19 (32%)
		lambda-1	1013..>1061	CDD:212564	8/47 (17%)
		zf-C2H2	1040..1062	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1070..1090	CDD:275368	6/19 (32%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368	4/14 (29%)
		C2H2 Zn finger	219..239	CDD:275368	4/19 (21%)
		COG5048	243..621	CDD:227381	102/442 (23%)
		C2H2 Zn finger	247..267	CDD:275368	9/19 (47%)
		C2H2 Zn finger	275..295	CDD:275368	6/19 (32%)
		C2H2 Zn finger	303..323	CDD:275368	2/19 (11%)
		C2H2 Zn finger	331..351	CDD:275368	1/19 (5%)
		C2H2 Zn finger	359..379	CDD:275368	4/19 (21%)
		C2H2 Zn finger	387..407	CDD:275368	6/20 (30%)
		C2H2 Zn finger	415..435	CDD:275368	4/22 (18%)
		C2H2 Zn finger	443..463	CDD:275368	2/19 (11%)
		C2H2 Zn finger	471..491	CDD:275368	5/23 (22%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	7/19 (37%)
		COG5048	551..>863	CDD:227381	87/455 (19%)
		C2H2 Zn finger	555..575	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	6/28 (21%)
		C2H2 Zn finger	611..631	CDD:275368	4/34 (12%)
		C2H2 Zn finger	639..659	CDD:275368	4/27 (15%)
		C2H2 Zn finger	699..715	CDD:275368	3/15 (20%)
		C2H2 Zn finger	723..743	CDD:275368	6/25 (24%)
		C2H2 Zn finger	751..771	CDD:275368	5/28 (18%)
		C2H2 Zn finger	779..799	CDD:275368	1/19 (5%)
		C2H2 Zn finger	807..827	CDD:275368	4/31 (13%)
		C2H2 Zn finger	835..855	CDD:275368	7/19 (37%)
		C2H2 Zn finger	863..883	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910