back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and ZNF219

DIOPT Version :10

Sequence 1:	NP_523548.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_057507.2	Gene:	ZNF219 / 51222	HGNCID:	13011	Length:	722	Species:	Homo sapiens

Alignment Length:	800	Identity:	179/800 - (22%)
Similarity:	253/800 - (31%)	Gaps:	312/800 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 THTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMD 666
            :..|||.|.|.:||:.|.....|..|:..|    |....|:||.|..:.:...:|:.|:|.|
Human    50 SRAGERRFPCPVCGKRFRFNSILALHLRAH----PGAQAFQCPHCGHRAAQRALLRSHLRTH--- 107

  Fly   667 DGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMD 731
                   .|......|.||.:|             |:....:.:....|:.||.|        |.
Human   108 -------QPERPRSPAARLLLE-------------LEERALLREARLGRARSSGG--------MQ 144

  Fly   732 STDDS------RDNSSAATATPHPLERERDREKERERRI-----PNDCSDERSHSNPDLTGGRSE 785
            :|..:      :..||:|...|:...:.| ...||||.:     |..|.        ..:.|.|:
Human   145 ATPATEGLARPQAPSSSAFRCPYCKGKFR-TSAERERHLHILHRPWKCG--------LCSFGSSQ 200

  Fly   786 SGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPP------------------ 832
            ..|:....|::..:....:.||..|.            |....|.||
Human   201 EEELLHHSLTAHGAPERPLAATSAAP------------PPQPQPQPPPQPEPRSVPQPEPEPEPE 253

  Fly   833 ---NLLLMAAAREEMHA-------------------LGHAH---AKFPLLPFGPLGFMGLHPPPN 872
               ......||.||..|                   .||..   |.|.            |..|
Human   254 REATPTPAPAAPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKHKASFD------------HACP- 305

  Fly   873 VCNLCFKMLPSLAALESHLQSEHAKE--------PATGHAQRPQCSDAG----SPYGAKLTLNP- 924
            ||..|||. |..  |::|:: .||.:        ||:|.|:.||..|.|    .|.|..|.|.|
Human   306 VCGRCFKE-PWF--LKNHMK-VHASKLGPLRAPGPASGPARAPQPPDLGLLAYEPLGPALLLAPA 366

  Fly   925 --NLFAKKPPS---SSSSSSGEKLP--ESSNP----PFPAENP--PATPIK------EDPDQEQL 970
              ....::|||   ..|..:||..|  |.:.|    .|....|  .|.|.:      |:|::|:.
Human   367 PTPAERREPPSLLGYLSLRAGEGRPNGEGAEPGPGRSFGGFRPLSSALPARARRHRAEEPEEEEE 431

  Fly   971 MVE-------EGAS----------AGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDF 1018
            :||       .|.|          .|||.|..|::...|....|.|....:.:...|
Human   432 VVEAEEETWARGRSLGSLASLHPRPGEGPGHSASAAGAQARSTATQEENGLLVGGTR-------- 488

  Fly  1019 QQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNL 1083
                ...|...:..|        |..|.::|.|:..|::|:|.|||::|::|..|..|.|..|:|
Human   489 ----PEGGRGATGKD--------CPFCGKSFRSAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSL 541

  Fly  1084 KVHMGTHMWTNPTSRRGRRMSLELPMRPGPNSGQGHPGSSAEQEFMQRRPELFFPYLPPFFNGLP 1148
            |.|:..|       .|.:|            ||.| ||...|               ||     |
Human   542 KYHLQRH-------HREQR------------SGAG-PGPPPE---------------PP-----P 566

  Fly  1149 PKPGELSP--GAFPNIPPPPFANGGKYPYPP---------------------------------- 1177
            |.....:|  ||.|:..|..:..|...|.||
Human   567 PSQRGSAPQSGAKPSPQPATWVEGASSPRPPSSGAGPGSRRKPASPGRTLRNGRGGEAEPLDLSL 631

  Fly  1178 -----------GLL----------GFPGFLAQHPYILERRSS--------------SKSPTPEPA 1207
                       |.|          |.|..:|.|..:...|.:              ::.|:.|..
Human   632 RAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQADASPPYARVPSGETP 696

  Fly  1208 QSPALREEEGSGNIWHPLSR 1227
            .||:...|||||     |||
Human   697 PSPSQEGEEGSG-----LSR 711

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.