DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment salr and ZNF219

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_005267796.1	Gene:	ZNF219 / 51222	HGNCID:	13011	Length:	768	Species:	Homo sapiens

Alignment Length:	1137	Identity:	212/1137 - (18%)
Similarity:	312/1137 - (27%)	Gaps:	526/1137 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 GTEDRKAEPEGYQSMMCD------ISSSLASSIITNHDPPP------------------------ 269
            |.::|::     |.:.|.      |||..:||:   |.|.|
Human     3 GQKERQS-----QLLPCSTAPVAFISSFSSSSL---HFPEPKNVKGVHGDLSPQGSRPRAPSGHL 59

  Fly   270 APNEP---NCLEMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFG 331
            ||:.|   ..|::.:......:.:.|..:.|....|           ||....:..|..|||.|.
Human    60 APSPPAFDGELDLQRYSNGPAVSAGSLGMGAVSWSE-----------SRAGERRFPCPVCGKRFR 113

  Fly   332 SYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQV 396
            ..|.|.:|||:|.|.:.|.|..||.:...:..|:.|.:.|....|
Human   114 FNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERP-------------------- 158

  Fly   397 QGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQE-----------IPVPQAEDLSKPMVKEKE 450
                   |.|.|..:.         ::||...:|:.           ...|..|.|::|......
Human   159 -------RSPAARLLL---------ELEERALLREARLGRARSSGGMQATPATEGLARPQAPSSS 207

  Fly   451 KSHSPVERVKTPKEVKTDAALPSSEKP------------EKEISKPVVTSSRRNGSVRK--RQTS 501
            ....|..:.|.....:.:..|....:|            |:|:....:|:   :|:..:  ..||
Human   208 AFRCPYCKGKFRTSAERERHLHILHRPWKCGLCSFGSSQEEELLHHSLTA---HGAPERPLAATS 269

  Fly   502 AVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKL 566
            |..|||...:                   ...||...|:.|.|.      |...|.:.|...:..
Human   270 AAPPPQPQPQ-------------------PPPQPEPRSVPQPEP------EPEPEREATPTPAPA 309

  Fly   567 QQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERP-----FRCKICGRAFATKGNLKA 626
                                                 ..|.|     |||::||::|.....||.
Human   310 -------------------------------------APEEPPAPPEFRCQVCGQSFTQSWFLKG 337

  Fly   627 HMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAER---LGIE 688
            ||..||..    ....||||.:.|.....|:.|:::|....|......||:.|..|.:   ||:
Human   338 HMRKHKAS----FDHACPVCGRCFKEPWFLKNHMKVHASKLGPLRAPGPASGPARAPQPPDLGL- 397

  Fly   689 DQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERE 753
              .:.:.||.:..|                                       |...||
Human   398 --LAYEPLGPALLL---------------------------------------APAPTP------ 415

  Fly   754 RDREKERERRIPNDCSDERSHSNPDLTGGRS-ESGEMPAMDLSSPSSNSGRIFATGLANGAA--- 814
                  .|||.|           |.|.|..| .:||                   |..||..
Human   416 ------AERREP-----------PSLLGYLSLRAGE-------------------GRPNGEGAEP 444

  Fly   815 GGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFK 879
            |.|...||...|...:|      |.||.
Human   445 GPGRSFGGFRPLSSALP------ARARR------------------------------------- 466

  Fly   880 MLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKP---PSSSSSSSGE 941
                      |...|..:|.....|:....: .|...|:..:|:|     :|   |..|:|::|.
Human   467 ----------HRAEEPEEEEEVVEAEEETWA-RGRSLGSLASLHP-----RPGEGPGHSASAAGA 515

  Fly   942 KLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQL 1006
            :...::.                  ||:..:..|.:..|| |.|||..
Human   516 QARSTAT------------------QEENGLLVGGTRPEG-GRGATGK----------------- 544

  Fly  1007 HAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCN 1071
                                              .|..|.::|.|:..|::|:|.|||::|::|.
Human   545 ----------------------------------DCPFCGKSFRSAHHLKVHLRVHTGERPYKCP 575

  Fly  1072 VCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMRPGPNSGQGHPGSSAEQEFMQRRPELF 1136
            .|..|.|..|:||.|:..|       .|.:|            ||.| ||...|
Human   576 HCDYAGTQSGSLKYHLQRH-------HREQR------------SGAG-PGPPPE----------- 609

  Fly  1137 FPYLPPFFNGLPPKPGELSP--GAFPNIPPPPFANGGKYPYPP---------------------- 1177
                ||     ||.....:|  ||.|:..|..:..|...|.||
Human   610 ----PP-----PPSQRGSAPQSGAKPSPQPATWVEGASSPRPPSSGAGPGSRRKPASPGRTLRNG 665

  Fly  1178 -----------------------GLL----------GFPGFLAQHPYILERRSS----------- 1198
                                   |.|          |.|..:|.|..:...|.:
Human   666 RGGEAEPLDLSLRAGPGGEAGPGGALHRCLFCPFATGAPELMALHLQVHHSRRARGRRPPQADAS 730

  Fly  1199 ---SKSPTPEPAQSPALREEEGSGNIWHPLSR 1227
               ::.|:.|...||:...|||||     |||
Human   731 PPYARVPSGETPPSPSQEGEEGSG-----LSR 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	10/21 (48%)
		C2H2 Zn finger	323..343	CDD:275368	10/19 (53%)
		zf-H2C2_2	335..360	CDD:290200	10/24 (42%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		C2H2 Zn finger	583..603	CDD:275368	0/19 (0%)
		zf-H2C2_2	595..620	CDD:290200	8/29 (28%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	6/47 (13%)
		zf-C2H2	1040..1062	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	10/24 (42%)
		C2H2 Zn finger	1070..1090	CDD:275368	8/19 (42%)
ZNF219	XP_005267796.1	C2H2 Zn finger	105..125	CDD:275368	10/19 (53%)
		C2H2 Zn finger	133..153	CDD:275368	5/19 (26%)
		C2H2 Zn finger	211..229	CDD:275368	2/17 (12%)
		C2H2 Zn finger	237..253	CDD:275368	2/15 (13%)
		zf-C2H2	320..342	CDD:278523	10/21 (48%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		ARS2	<350..454	CDD:282772	38/187 (20%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		C2H2 Zn finger	546..566	CDD:275368	7/19 (37%)
		zf-C2H2	546..566	CDD:278523	7/19 (37%)
		zf-H2C2_2	558..580	CDD:290200	9/21 (43%)
		C2H2 Zn finger	574..594	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930