DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Sall2

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_056587.2	Gene:	Sall2 / 50524	MGIID:	1354373	Length:	1004	Species:	Mus musculus

Alignment Length:	1237	Identity:	285/1237 - (23%)
Similarity:	433/1237 - (35%)	Gaps:	424/1237 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 ERDRDTLLAK---------ELDADSNNNGTEPQM-------------EAEAVPE---------SD 72
            |.|...:.||         |..|..|:..|:|.:             .|.:.|.         .|
Mouse    29 EEDHPQVCAKCCAQFSDPTEFLAHQNSCCTDPPVMVIIGGQENPSNSSASSAPRPEGHSRSQVMD 93

  Fly    73 TERETAEERGEEQEPE-------NSNEALDLSLISSGGRESLPGSGHVSLEALQHTKVAVAQFAA 130
            ||.....:.|....|:       ...|:....|:::.|..:..|.|.:         :|..:..|
Mouse    94 TEHSNPPDSGSSGAPDPTWGPERRGEESSGQFLVAATGTAAGGGGGLI---------LASPKLGA 149

  Fly   131 T--------------------AMAGNHQSADLAMVQSTIFNVQRQHLMQLQLIQHLQSQLKRAEA 175
            |                    .:...|.:..|.:.:..:  :|::.:.|:|:.:.:..|:
Mouse   150 TPLPPESTPAPPPPPPPPPPPGVGSGHLNIPLILEELRV--LQQRQIHQMQMTEQICRQV----- 207

  Fly   176 AALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQDQESRREENSKTDKRGTEDRK 240
            ..||  |..........|...|.....:..|..|.|....:..|..::....:|.:...|.|..|
Mouse   208 LLLG--SLGQTVGAPASPSELPGTGAASSTKPLLPLFSPIKPAQTGKTLASSSSSSSSSGAEPPK 270

  Fly   241 A------EPEGYQSMMCDISSSLASSIITNHDPPPAPNEPNCLEMLQRRTEEVLDS--------- 290
            .      .|.|.|....      ...:..:|.|.|||:     ..|...|::::.|
Mouse   271 QAFFHLYHPLGSQHPFS------VGGVGRSHKPTPAPS-----PALPGSTDQLIASPHLAFPGTT 324

  Fly   291 ---ASQSLHAAQMQEE-----------------YSEYASKEAQSRGEIFKHRCKYCGKIFGSYSA 335
               |:|.|.||:..|.                 |.|..|...:..|   :|:|::|.|:|||.||
Mouse   325 GLLAAQCLGAARGLEAAASPGLLKPKNGSGELGYGEVISSLEKPGG---RHKCRFCAKVFGSDSA 386

  Fly   336 LQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPN-----VGHSGQGQ 395
            |||||||||||||:.|||||::|||:||||||:.||.:.:|.:.:.|...|.     :..||
Mouse   387 LQIHLRSHTGERPYKCNVCGNRFTTRGNLKVHFHRHREKYPHVQMNPHPVPEHLDYVITSSG--- 448

  Fly   396 VQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKE--KSHSPVER 458
                     ||:...|             .||:..:|...|......||:|....  .:...:..
Mouse   449 ---------LPYGMSV-------------PPEKAEEEAGTPGGGVERKPLVASTTALSATESLTL 491

  Fly   459 VKTPKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKL 523
            :.|.........||:..|  ..:.|.|...|:.:.:         :||..       |...||.:
Mouse   492 LSTGTSTAVAPGLPTFNK--FVLMKAVEPKSKADEN---------TPPGS-------EGSAIAGV 538

  Fly   524 VRRSSASRESQPAEYSLAQMERIIDK--SWEDLIEIDKT-----------------SETSKLQQL 569
            ....||:|         .|:.:::..  ||..|....|:                 |||||||||
Mouse   539 ADSGSATR---------MQLSKLVTSLPSWALLTNHLKSTGSFPFPYVLEPLGASPSETSKLQQL 594

  Fly   570 VDNIE-----------------------NKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRC 611
            |:.|:                       :..:.||||:.|.:|:||..:|::|...|.|||||:|
Mouse   595 VEKIDRQGAVAVASTASGAPTTSAPAPSSSASGPNQCVICLRVLSCPRALRLHYGQHGGERPFKC 659

  Fly   612 KICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPA 676
            |:|||||:|:|||:||...||..|..|:|..||:|.:||:|.:.||||:|:|.     ||| .|.
Mouse   660 KVCGRAFSTRGNLRAHFVGHKTSPAARAQNSCPICQKKFTNAVTLQQHVRMHL-----GGQ-IPN 718

  Fly   677 ANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSS 741
            .....:|..|...:||:                    ::|.:|..|.|.:
Mouse   719 GGSALSEGGGAAQENSS--------------------EQSTASGPGSFPQ--------------- 748

  Fly   742 AATATPHPLERERDREKERERRIPNDCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFA 806
            ..:..|.| |.|...|:|.:.....|.:||.|     |.|..||||...|:.:...|..
Mouse   749 PQSQQPSP-EEEMSEEEEEDEEEEEDVTDEDS-----LAGRGSESGGEKAISVRGDSEE------ 801

  Fly   807 TGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPP 871
                                          ::.|.||
Mouse   802 ------------------------------VSGAEEE---------------------------- 808

  Fly   872 NVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPSSSS 936
                    :..|:||                                            |.:...
Mouse   809 --------VATSVAA--------------------------------------------PTTVKE 821

  Fly   937 SSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGS--------GTGATSNYPQE 993
            ..|.||.|:.:.||     ||..|  ::.|..|.| |:|.|...|:        ||.:......:
Mouse   822 MDSNEKAPQHTLPP-----PPPPP--DNLDHPQPM-EQGTSDVSGAMEEEAKLEGTSSPMAALTQ 878

  Fly   994 AGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIH 1058
            .|:...:.:..:|:   .|.:        |...|..||      .:..|.||.::|.:.:||:.|
Mouse   879 EGEGTSTPLVEELN---LPEA--------MKKDPGESS------GRKACEVCGQSFPTQTALEEH 926

  Fly  1059 MRTHTGDKP-FQCNVCQKAFTTKGNLKVHM-GTHMWTNPTSRRGRRMSLELPMRPGPNSGQGHPG 1121
            .:||..|.| |.|..|::.|..:..||.|| ..|....|.:..|.:....|.:.||.:|....||
Mouse   927 QKTHPKDGPLFTCVFCRQGFLDRATLKKHMLLAHHQVPPFAPHGPQNIATLSLVPGCSSSIPSPG 991

  Fly  1122 SS 1123
            .|
Mouse   992 LS 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	15/21 (71%)
		C2H2 Zn finger	323..343	CDD:275368	14/19 (74%)
		zf-H2C2_2	335..360	CDD:290200	20/24 (83%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	595..620	CDD:290200	15/24 (63%)
		C2H2 Zn finger	611..631	CDD:275368	13/19 (68%)
		C2H2 Zn finger	643..663	CDD:275368	11/19 (58%)
		lambda-1	1013..>1061	CDD:212564	11/47 (23%)
		zf-C2H2	1040..1062	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	11/25 (44%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/20 (35%)
Sall2	NP_056587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..122		12/70 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..177		5/48 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..270		9/49 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..307		6/32 (19%)
		C2H2 Zn finger	374..394	CDD:275368	14/19 (74%)
		zf-H2C2_2	386..411	CDD:290200	20/24 (83%)
		C2H2 Zn finger	402..422	CDD:275368	14/19 (74%)
		C2H2 Zn finger	631..651	CDD:275368	7/19 (37%)
		zf-H2C2_2	643..668	CDD:290200	15/24 (63%)
		C2H2 Zn finger	659..679	CDD:275368	13/19 (68%)
		zf-C2H2	690..711	CDD:278523	11/20 (55%)
		C2H2 Zn finger	691..711	CDD:275368	11/19 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..910		62/385 (16%)
		C2H2 Zn finger	910..930	CDD:275368	7/19 (37%)
		zf-C2H2	910..930	CDD:278523	7/19 (37%)
		C2H2 Zn finger	939..957	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43008
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.810