DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Zfp560

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001004190.2	Gene:	Zfp560 / 434377	MGIID:	1915280	Length:	754	Species:	Mus musculus

Alignment Length:	1085	Identity:	205/1085 - (18%)
Similarity:	311/1085 - (28%)	Gaps:	474/1085 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 VSLEALQHTKVAVAQFAATAMAGNHQSADLAMVQSTIFNVQRQHLMQLQ----LIQHLQSQLKRA 173
            |.||..|:......|...:..:...::.:|.:|:.   .|.:...:||.    :.|....|||.:
Mouse    69 VMLENYQNLATLGCQLIKSRYSFCLEAEELRVVKK---RVHQDWAIQLNPRGTMFQRDIFQLKMS 130

  Fly   174 EAAALGRHSHSDEEEEEPEPEPEPKKQPTNGL-------------------------KEELELEQ 213
            ....| .:||:.:|..:.:|..|..|:|...|                         ||....:.
Mouse   131 NEIQL-PNSHNGKELCDIKPPGEIIKEPPCSLTYIGIENTGNIYDCVQYGQLFPVCPKETSSADT 194

  Fly   214 GPESEQ-DQESRREENSKTDKRGTEDRKAEPEGYQSMMCDISSSLASSIITNHDPPPAPNEPNCL 277
            ||...| .::.....::.......:.:..|...:|.:. |..|||       ..|..:.:|....
Mouse   195 GPGLRQYGKDFSMIASTAYQTTCVQSKFIESSEFQQVF-DSQSSL-------QRPGGSHSEDKLS 251

  Fly   278 EMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFK-----------------HRCKY 325
            |.:|     ..|:.|.:|..|:..:..:...|.|.:..|:.||                 ::||.
Mouse   252 ESVQ-----CGDTFSPALSHAESAQTCTGKKSYECKECGKSFKYSANLNIHMRTHTGEKPYQCKE 311

  Fly   326 CGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGH 390
            |||.|.....|..||::||.|:||.|.|||..|.....|..|::.||.|.|......|.| ..|.
Mouse   312 CGKAFSRCYPLTQHLKTHTEEKPFECKVCGKCFRNSSCLNDHFRVHTGIKPYKCKDCGKA-FTGR 375

  Fly   391 SGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSP 455
            ||                                                |||         |.|
Mouse   376 SG------------------------------------------------LSK---------HLP 383

  Fly   456 VERVKTPKEVK-TDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHL- 518
            ....:.|.|.| ...|.||:.                                     .|::|:
Mouse   384 THTGEKPYECKECGKAFPSTS-------------------------------------GLIKHMK 411

  Fly   519 -HIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQ 582
             |:.                      ||                                  |.:
Mouse   412 SHMG----------------------ER----------------------------------PFE 420

  Fly   583 CIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCH 647
            |..|.|..:..|:|..|:||||||:||.|::||:||.....|:.||..|..:.|    :.|..|.
Mouse   421 CDHCGKAFASSSTLITHLRTHTGEKPFECQVCGKAFTCSSYLRIHMRTHTGEKP----YVCKECG 481

  Fly   648 QKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHS 712
            :.|:....|.:|:|.||           ..||.|....|       |:...|..|  ...|..|:
Mouse   482 RAFTERTSLTKHLRTHT-----------GENPFECNMCG-------KAFACSSYL--HNHIRTHT 526

  Fly   713 GQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSNP 777
            |::                                                 |..|
Mouse   527 GEK-------------------------------------------------PYVC--------- 533

  Fly   778 DLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAARE 842
                  .|.|:  |..:||..|...||
Mouse   534 ------KECGK--AFTVSSHLSKHVRI-------------------------------------- 552

  Fly   843 EMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRP 907
                  |...|                 |:.|..|.|.....:.|..|:::...::|.
Mouse   553 ------HTGEK-----------------PHKCEECGKAFTVRSGLTKHIRTHTGEKPY------- 587

  Fly   908 QCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMV 972
            .|.:.|..:    |.:..|...|     .|.:|||       |:..:
Mouse   588 NCKECGKAF----TTSSGLLEHK-----RSHTGEK-------PYECD------------------ 618

  Fly   973 EEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVN 1037
                ..|:..   |:|:|         .:..:::|....|     |:
Mouse   619 ----QCGKAF---ASSSY---------LIAHLRIHTGEKP-----FE------------------ 644

  Fly  1038 NKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNL----KVHMGTHMWT----- 1093
                |:.|.:.|:.||.|.||||||||:||:.|..|.|.|....:|    ::|.|...:|
Mouse   645 ----CNECGKAFTCSSYLHIHMRTHTGEKPYDCKECGKTFAVYSHLSKHVRIHSGEKAYTCKSDG 705

  Fly  1094 ---NPTSRRGRRMSLELPMRPGPNSGQG---------HPGSSAEQ 1126
               :.:.|.....|||:....|.|....         ||.|..::
Mouse   706 IAFSRSHRTEHLKSLEINSFVGGNEETALESSIALTVHPNSQWQE 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	9/21 (43%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	13/24 (54%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	595..620	CDD:290200	15/24 (63%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	643..663	CDD:275368	6/19 (32%)
		lambda-1	1013..>1061	CDD:212564	10/47 (21%)
		zf-C2H2	1040..1062	CDD:278523	10/21 (48%)
		C2H2 Zn finger	1042..1062	CDD:275368	10/19 (53%)
		zf-H2C2_2	1054..1079	CDD:290200	15/24 (63%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/23 (30%)
Zfp560	NP_001004190.2	KRAB	41..97	CDD:214630	5/27 (19%)
		KRAB	41..80	CDD:279668	4/10 (40%)
		COG5048	276..689	CDD:227381	151/798 (19%)
		zf-C2H2	279..301	CDD:278523	4/21 (19%)
		C2H2 Zn finger	281..301	CDD:275368	3/19 (16%)
		zf-H2C2_2	293..318	CDD:290200	6/24 (25%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		zf-H2C2_2	322..346	CDD:290200	13/23 (57%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		zf-H2C2_2	350..373	CDD:290200	8/23 (35%)
		C2H2 Zn finger	365..385	CDD:275368	10/77 (13%)
		C2H2 Zn finger	393..413	CDD:275368	6/56 (11%)
		zf-H2C2_2	406..430	CDD:290200	9/79 (11%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		zf-H2C2_2	434..458	CDD:290200	15/23 (65%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		zf-H2C2_2	461..485	CDD:290200	7/27 (26%)
		C2H2 Zn finger	477..497	CDD:275368	6/19 (32%)
		zf-H2C2_2	489..514	CDD:290200	10/42 (24%)
		C2H2 Zn finger	505..525	CDD:275368	5/28 (18%)
		zf-H2C2_2	520..541	CDD:290200	8/86 (9%)
		C2H2 Zn finger	533..553	CDD:275368	9/80 (11%)
		zf-H2C2_2	545..569	CDD:290200	9/84 (11%)
		C2H2 Zn finger	561..581	CDD:275368	5/19 (26%)
		zf-H2C2_2	574..598	CDD:290200	5/34 (15%)
		C2H2 Zn finger	589..609	CDD:275368	5/28 (18%)
		zf-H2C2_2	602..626	CDD:290200	8/60 (13%)
		C2H2 Zn finger	617..637	CDD:275368	4/53 (8%)
		zf-H2C2_2	629..654	CDD:290200	7/60 (12%)
		C2H2 Zn finger	645..665	CDD:275368	10/19 (53%)
		zf-H2C2_2	661..681	CDD:290200	12/19 (63%)
		C2H2 Zn finger	673..693	CDD:275368	5/19 (26%)
		C2H2 Zn finger	701..718	CDD:275368	1/16 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000