DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment salr and Zfp229

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001158148.1	Gene:	Zfp229 / 381067	MGIID:	2679295	Length:	705	Species:	Mus musculus

Alignment Length:	863	Identity:	166/863 - (19%)
Similarity:	250/863 - (28%)	Gaps:	384/863 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 LDSASQSLHAAQMQEE----YSEYA------SKEAQSRG-EIFKHRCKYCGKIFGSY-------- 333
            ::|.:.|.|.:...||    |.:|.      |..:||.| .|.:...|.|.|.|||:
Mouse   158 IESTNLSRHKSMHTEEEPCKYKDYGKSLSLFSNVSQSHGIYIGEKEYKECDKTFGSFPKLVQLRI 222

  Fly   334 -------------------SALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPML 379
                               |:|..|.|::|||:|::|..|...|....:||.||:.|
Mouse   223 HSGKNPQKCRKCRTGFRTCSSLSTHQRTYTGEKPWICTECDKAFRWLSDLKTHYRIH-------- 279

  Fly   380 LPPGVAPNVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSK- 443
              ||..|         .:.::......|            .|.:.|.:.|.:       ..|.|
Mouse   280 --PGEKP---------FKCKECDRSFTF------------YNSLREHQNIHK-------GKLYKC 314

  Fly   444 ----------PMVKEKEKSHSPVERVKTPKEVKT---------DAALPSSEKPE--KEISKPVVT 487
                      ..::..||.|:..:..|..:.:|:         .|...:.|||.  ||..|....
Mouse   315 WKCDKFFTRCSSLRAHEKIHTGEKPFKCKECIKSFYMLSQLRKHARTHTGEKPYKCKECDKSFTY 379

  Fly   488 SSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWE 552
            ||    |:|:.|                 ::|..||              |...:.::..  :|.
Mouse   380 SS----SLREHQ-----------------NMHAGKL--------------YKCQECDKCF--TWC 407

  Fly   553 DLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRA 617
            ..:...:...|.:             .|.:|..|.|.....|.|:.|.||||||:|::||.|.::
Mouse   408 SSLRAHEKIHTGE-------------KPFKCKECGKSFCMLSQLRKHARTHTGEKPYKCKECEKS 459

  Fly   618 FATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEA 682
            |.....|:.|..||..:.|    :||..|.:.|.....|:.|.|.||           ...|.:.
Mouse   460 FTQCSTLRIHQKIHAGEKP----YKCKECGKCFYKLSYLKVHYRTHT-----------GEKPYQC 509

  Fly   683 ERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATP 747
            :..|       |.......|.....|  |:|::....  .:.|:..|..||  .|.:.|...|.|
Mouse   510 KECG-------KGFSQLSCLKSHERI--HTGEKPYKC--SECDKSFTHCST--CRRHQSTHAAKP 561

  Fly   748 HPLERERDREKERERRIPNDCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANG 812
            :..| |.|:...::       |..|:|.       :..:||.|
Mouse   562 YKCE-ECDKSFAKQ-------SSLRTHQ-------KVHAGEKP---------------------- 589

  Fly   813 AAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLC 877
                                                  ||                     |..|
Mouse   590 --------------------------------------HA---------------------CKEC 595

  Fly   878 FKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEK 942
            .|....|:.|:.|.:..                                            :|||
Mouse   596 GKAFYQLSHLKVHYRIH--------------------------------------------TGEK 616

  Fly   943 LPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLH 1007
                                                            |.:..:.|:|..|
Mouse   617 ------------------------------------------------PYKCDECEKSFTK---- 629

  Fly  1008 AHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNV 1072
                 .|.|...|.:.:...|           |.|..|.:.|...|.|.||.|||||:||::|:.
Mouse   630 -----CSSLRTHQKIHAGEKP-----------HACEKCGKAFYHLSHLNIHYRTHTGEKPYKCSD 678

  Fly  1073 CQKAFTTKGNLKVHMGTH 1090
            |.|:|||..||:.|...|
Mouse   679 CDKSFTTLANLRRHHRLH 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	10/48 (21%)
		C2H2 Zn finger	323..343	CDD:275368	10/46 (22%)
		zf-H2C2_2	335..360	CDD:290200	10/24 (42%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	595..620	CDD:290200	13/24 (54%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		C2H2 Zn finger	643..663	CDD:275368	6/19 (32%)
		lambda-1	1013..>1061	CDD:212564	12/47 (26%)
		zf-C2H2	1040..1062	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1042..1062	CDD:275368	8/19 (42%)
		zf-H2C2_2	1054..1079	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1070..1090	CDD:275368	9/19 (47%)
Zfp229	NP_001158148.1	KRAB	13..73	CDD:214630
		C2H2 Zn finger	205..223	CDD:275368	6/17 (35%)
		COG5048	<227..412	CDD:227381	47/259 (18%)
		C2H2 Zn finger	231..251	CDD:275368	4/19 (21%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		C2H2 Zn finger	287..307	CDD:275368	3/31 (10%)
		C2H2 Zn finger	314..334	CDD:275368	2/19 (11%)
		COG5048	338..704	CDD:227381	120/645 (19%)
		C2H2 Zn finger	342..362	CDD:275368	2/19 (11%)
		C2H2 Zn finger	370..390	CDD:275368	8/40 (20%)
		C2H2 Zn finger	397..417	CDD:275368	1/21 (5%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
		C2H2 Zn finger	509..529	CDD:275368	4/28 (14%)
		C2H2 Zn finger	537..557	CDD:275368	6/23 (26%)
		C2H2 Zn finger	564..584	CDD:275368	6/34 (18%)
		C2H2 Zn finger	592..612	CDD:275368	6/19 (32%)
		C2H2 Zn finger	620..640	CDD:275368	6/28 (21%)
		C2H2 Zn finger	648..668	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000