DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and ZNF699

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_940937.1	Gene:	ZNF699 / 374879	HGNCID:	24750	Length:	642	Species:	Homo sapiens

Alignment Length:	984	Identity:	178/984 - (18%)
Similarity:	288/984 - (29%)	Gaps:	449/984 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 SADLAMVQSTIFNVQRQHLMQLQLIQHLQSQLKRAEAAALGRHSHSD------EEEEEPEPEPEP 197
            :.|....:..:.::.:::|.:..::::.|:      .|:||...|:.      |:||:.:.
Human    25 AVDFTQEEWALLDLAQRNLYRDVMLENFQN------LASLGYPLHTPHLISQWEQEEDLQT---- 79

  Fly   198 KKQPTNGLKEEL-------ELEQGPESE-QDQESRREENSKTDKRGTEDR----KAEPEGYQSMM 250
                   :|.||       |..:|.|:: :..||...::...:|...|.:    |.....:.|:
Human    80 -------VKRELIQGIFMGEHREGFETQLKTNESVASQDICGEKISNEQKIVRFKRNDSWFSSL- 136

  Fly   251 CDISSSLASSIITNHDPPPAPNEPNCLEMLQRRTEE------VLDSASQSLHAAQMQEEYSEYAS 309
                          |:     |:.:|....|.::.|      ::::..:.....|..:.:|:..:
Human   137 --------------HE-----NQESCGIDYQNKSHERHLRNHMVENIYECYEENQDGQTFSQVPN 182

  Fly   310 KEAQSRG-EIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQ 373
            .::..|. |:....|..|||.|..:|:|:.|:|||||.:|:.|..||..|......|.|
Human   183 LDSLKRNTEVKSCECHECGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLACFKKH------ 241

  Fly   374 IFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQA 438

Human   242 ----------------------------------------------------------------- 241

  Fly   439 EDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPSSEKPE--KEISKPVVTSSRRNGSVRKRQTS 501
                                :|||.|          |||.  ||.:|....||
Human   242 --------------------MKTPTE----------EKPYECKECTKAFSCSS------------ 264

  Fly   502 AVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKL 566
                                                :..|.|:          |.|.||:
Human   265 ------------------------------------FFRAHMK----------IHIGKTN----- 278

  Fly   567 QQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIH 631
                          .:|..|.|..||.|||..|.|.|:|::|:.||.||:||:...:|..|..||
Human   279 --------------YECKECGKGFSCSSSLTEHKRIHSGDKPYECKECGKAFSCSSSLSKHKRIH 329

  Fly   632 KIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSL 696
            ....|    ::|..|.:.||:...|..||||||           ...|.|.:..|.....|:|..
Human   330 SGDKP----YECKECGKAFSSSSHLIIHIRIHT-----------GEKPYECKECGKAFSESSKLT 379

  Fly   697 GTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERE 761
            ....|         |:|::                               |:     :.:|..:.
Human   380 VHGRT---------HTGEK-------------------------------PY-----KCKECGKA 399

  Fly   762 RRIPNDCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPML 826
            ...|:..|...          |..:||.|...|     ..|:.|.
Human   400 YNCPSSLSIHM----------RKHTGEKPYECL-----ECGKAFY-------------------- 429

  Fly   827 GMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHL 891
             :|...|..:...:||:                           |..|..|.|.....::..:|:
Human   430 -LPTSLNTHVKNQSREK---------------------------PYECKECGKAFSCPSSFRAHV 466

  Fly   892 QSEHAKEPATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENP 956
            : :|     ||..|. :|.:.|..:....:|..:|         .:.||||       |:..
Human   467 R-DH-----TGKIQY-ECKECGKTFSRSSSLTEHL---------RTHSGEK-------PYEC--- 505

  Fly   957 PATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQA 1021
                                               :|.|.|..|...:.:|..
Human   506 -----------------------------------KECGKAFISSSHLTVHIR------------ 523

  Fly  1022 LMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVH 1086
                   |.:.:.|    :.|..|.:.|...|||:||||||||:||::|..|.|||.....|.||
Human   524 -------THTGEKP----YECKKCGKAFIYPSALRIHMRTHTGEKPYECKECGKAFRHSSYLTVH 577

  Fly  1087 MGTHMWTNP 1095
            ...|....|
Human   578 ARMHTGEKP 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	9/21 (43%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	12/24 (50%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	10/19 (53%)
		zf-H2C2_2	595..620	CDD:290200	13/24 (54%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	643..663	CDD:275368	8/19 (42%)
		lambda-1	1013..>1061	CDD:212564	11/47 (23%)
		zf-C2H2	1040..1062	CDD:278523	10/21 (48%)
		C2H2 Zn finger	1042..1062	CDD:275368	10/19 (53%)
		zf-H2C2_2	1054..1079	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1070..1090	CDD:275368	8/19 (42%)
ZNF699	NP_940937.1	KRAB	19..79	CDD:214630	10/59 (17%)
		KRAB	19..58	CDD:279668	4/38 (11%)
		C2H2 Zn finger	143..159	CDD:275368	3/15 (20%)
		C2H2 Zn finger	167..189	CDD:275368	2/21 (10%)
		COG5048	171..605	CDD:227381	151/801 (19%)
		C2H2 Zn finger	197..217	CDD:275368	9/19 (47%)
		zf-H2C2_2	209..233	CDD:290200	11/23 (48%)
		C2H2 Zn finger	225..245	CDD:275368	7/110 (6%)
		C2H2 Zn finger	253..273	CDD:275368	7/77 (9%)
		C2H2 Zn finger	281..301	CDD:275368	10/19 (53%)
		zf-H2C2_2	293..318	CDD:290200	13/24 (54%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		zf-H2C2_2	321..346	CDD:290200	8/28 (29%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	349..373	CDD:290200	10/34 (29%)
		C2H2 Zn finger	365..385	CDD:275368	4/28 (14%)
		C2H2 Zn finger	393..413	CDD:275368	4/29 (14%)
		zf-H2C2_2	405..428	CDD:290200	7/37 (19%)
		C2H2 Zn finger	421..439	CDD:275368	5/43 (12%)
		C2H2 Zn finger	449..469	CDD:275368	4/20 (20%)
		zf-C2H2	475..497	CDD:278523	4/31 (13%)
		C2H2 Zn finger	477..497	CDD:275368	4/28 (14%)
		zf-H2C2_2	489..514	CDD:290200	10/78 (13%)
		C2H2 Zn finger	505..525	CDD:275368	5/76 (7%)
		zf-H2C2_2	517..542	CDD:290200	6/47 (13%)
		C2H2 Zn finger	533..553	CDD:275368	10/19 (53%)
		zf-H2C2_2	545..570	CDD:290200	17/24 (71%)
		C2H2 Zn finger	561..581	CDD:275368	8/19 (42%)
		C2H2 Zn finger	589..609	CDD:275368
		zf-H2C2_2	601..626	CDD:290200
		C2H2 Zn finger	617..637	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910