DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and peb

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001014722.1	Gene:	peb / 31391	FlyBaseID:	FBgn0003053	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	1048	Identity:	227/1048 - (21%)
Similarity:	335/1048 - (31%)	Gaps:	393/1048 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 QEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERV---KTPKEVKTDAALPSSEKP 477
            |:||.|...|.|..||.              ::...|.|.:|.:   :|||::..::....:...
  Fly     5 QQQHNNSTVESEMERQR--------------RDSTTSESSLEHLDLGRTPKKLGGNSGSTQTTST 55

  Fly   478 EKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKL------------------- 523
            ..|::  .|||||:. .:|..|.:.....|..::.||:....:|:.
  Fly    56 PHELA--TVTSSRKR-KIRHLQLNHHQQQQHHQQSDLLSDEDVAEAEAEEDEDEEDGDQVAALGS 117

  Fly   524 -------VRRS--SASRESQPAEYSLAQMERI-----IDKSWEDLIE---IDKTSETSKLQQL-- 569
                   .|||  :.::.|...:||......:     :::|...|.|   :|.:|.|.....|
  Fly   118 RNLGRHKQRRSGGATTQASIVMDYSSGDASSLRKKFRLNRSAASLSESGFVDASSTTGHSGYLGN 182

  Fly   570 ----------------------------------------------------------------- 569

  Fly   183 SSSATNTTATSGIGASAVAPSPVGGAAINAASSSSGSSSGGSGGSSPQGQCLSSGESGIGAGDEH 247

  Fly   570 -----------------------VDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRC 611
                                   ..|..|..|:...|..|.||:|..|||..|:..|||||||.|
  Fly   248 MKYLCPICEVVSATPHEFTNHIRCHNYANGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNC 312

  Fly   612 KICGRAFATKGNLKAHMSIHK----IKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQ 672
            :.|...|.|.||:..||..||    .:...:||.:..:..|:.|     ||..|.......|..|
  Fly   313 RYCHLTFTTNGNMHRHMRTHKQHQVAQSQSQSQQQQSLQQQQQS-----QQQRRQQQQHQPSQQQ 372

  Fly   673 GAPAANPGEAERLG------IEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMD 731
                .||.:.:.:|      .|...|:.|..|    |.|   |.||..||.|
  Fly   373 ----QNPAQQQLMGNTLSARAESYESDASCST----DVS---SGHSHSRSSS------------- 413

  Fly   732 STDDSRDNSSAATATPHPLE------RERDREKERERRIPNDCSDE--RSHSNPDLTGGRSESGE 788
            |.:::.:||..|......||      .::|.| .::||:....::.  .|....|:....::..:
  Fly   414 SLNNNNNNSHKANNNLKDLEELEVSTEDQDTE-NKQRRLKTTINNNIIESEQQEDMDDEEADDAD 477

  Fly   789 MPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAK 853
            : ||..|:|.      .||.||..:|.|.:.....|   .|.....||::
  Fly   478 V-AMLTSTPD------VATLLAGASASGAASRSPTP---SPSASPALLLS--------------- 517

  Fly   854 FPLLPFGPLGFMGLHPPPNVCNLC----FKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGS 914
                                |..|    |:.||:|..   ||.:.|:..||       :|.|...
  Fly   518 --------------------CPACGASDFETLPALCV---HLDAMHSDIPA-------KCRDCEV 552

  Fly   915 PYGAKLTLN------PNLFA-KKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMV 972
            .:.....|.      ||..| ..||...:|||          |...|.|......:|.|.||  .
  Fly   553 IFATHRQLQSHCCRLPNALAGGLPPLLGASSS----------PLHNEEPEDEEHGDDEDLEQ--K 605

  Fly   973 EEGASAGE------------GSGTGATSNYP----QEAGDAE-----QSLMKMQLHAHRFPASPL 1016
            |..||..|            .:|.||.|:.|    .|..|.:     ||::.|...:..|..
  Fly   606 ERLASQSEDFFHQLYLKHKTANGCGAISHPPSPIKHEPADTKDLADIQSILNMTSSSSSFLR--- 667

  Fly  1017 DFQQALMSAGPPTSSLD----------------------------------PPV------NNKHF 1041
            :|:|::.:......|||                                  |.:      |..|.
  Fly   668 NFEQSVNTPNSSQYSLDGRDQEEEAQDAFTSEFRRMKLRGEFPCKLCTAVFPNLRALKGHNRVHL 732

  Fly  1042 ----------CHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHM-GTHMWTNP 1095
                      |::|.......:||..|||||.||:|::|.||..|||||.|.:.|: ..|   ..
  Fly   733 GAVGPAGPFRCNMCPYAVCDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRH---GK 794

  Fly  1096 TSRRGRRMSLELPMRPGPNSGQGHPGSSAEQEFMQRRPELFFPYLPPFFNGLPPKPGE-LSPGAF 1159
            |||...:.::..           ||...|..|..:.|                  .|| |:..:|
  Fly   795 TSREEVKRAIVY-----------HPAEDAGCEDSKSR------------------LGEDLADTSF 830

  Fly  1160 PNI---PPPPFANGGKYPYPPGLLGFPGFLA---QHPYI------LERRSSSKSPTPEPAQSPAL 1212
            .:|   ||||..|..|......||| ...||   |.|.:      |::....|...|.|.|....
  Fly   831 RSISPTPPPPPVNESKSQLKHMLLG-ENHLAPVNQQPPLKIQVKSLDQLVDKKPSAPAPQQQQQQ 894

  Fly  1213 REEEGSGN 1220
            :::|.||:
  Fly   895 QQQEKSGS 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523
		C2H2 Zn finger	323..343	CDD:275368
		zf-H2C2_2	335..360	CDD:290200
		C2H2 Zn finger	351..371	CDD:275368
		C2H2 Zn finger	583..603	CDD:275368	9/19 (47%)
		zf-H2C2_2	595..620	CDD:290200	13/24 (54%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	643..663	CDD:275368	5/19 (26%)
		lambda-1	1013..>1061	CDD:212564	14/97 (14%)
		zf-C2H2	1040..1062	CDD:278523	8/31 (26%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	15/24 (63%)
		C2H2 Zn finger	1070..1090	CDD:275368	10/20 (50%)
peb	NP_001014722.1	C2H2 Zn finger	252..272	CDD:275368	0/19 (0%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-H2C2_2	296..321	CDD:290200	13/24 (54%)
		C2H2 Zn finger	312..332	CDD:275368	8/19 (42%)
		C2H2 Zn finger	711..731	CDD:275368	2/19 (11%)
		C2H2 Zn finger	743..763	CDD:275368	7/19 (37%)
		zf-H2C2_2	755..780	CDD:290200	15/24 (63%)
		C2H2 Zn finger	771..789	CDD:275368	10/17 (59%)
		C2H2 Zn finger	1061..1079	CDD:275368
		PopZ	1299..>1430	CDD:226348
		C2H2 Zn finger	1453..1473	CDD:275370
		zf-H2C2_2	1465..1490	CDD:290200
		C2H2 Zn finger	1481..1502	CDD:275370
		C2H2 Zn finger	1706..1726	CDD:275368
		zf-H2C2_2	1718..1742	CDD:290200
		C2H2 Zn finger	1734..1754	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930