DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Zfp668

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_017444703.1	Gene:	Zfp668 / 309002	RGDID:	1308623	Length:	645	Species:	Rattus norvegicus

Alignment Length:	951	Identity:	186/951 - (19%)
Similarity:	264/951 - (27%)	Gaps:	441/951 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 HSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQDQESRREENSKTDKRGTEDRKAEPEG 245
            |:.:|..||..|.:|                      :.|.|.:.||.|.....|:   .|:|..
  Rat    70 HTTTDCTEEVNEVQP----------------------KVDAEPKAEEASGDKVSGS---VAKPRP 109

  Fly   246 YQSMMCDISSSLASSI------ITNHDPPPAPN------EPNCLEMLQRRTEEVLDSASQSLHAA 298
            |...:|..:...|..:      .|...|.|.|.      :|.||.                :|.
  Rat   110 YACPLCPKAYKTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLR----------------VHL- 157

  Fly   299 QMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGN 363
                         |...||: ..||.:|.|.:|:.|.|:||.|.||||||:.|..||..|.....
  Rat   158 -------------ASHAGEL-PFRCTHCPKAYGTLSKLKIHQRGHTGERPYACTDCGKSFADPSV 208

  Fly   364 LKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEE 428
            .:.|  |.|                 |:|                  :.|...|:......|.::
  Rat   209 FRKH--RRT-----------------HAG------------------LRPYSCERCGKAYAELKD 236

  Fly   429 IRQEIPVPQAEDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPSSEKPE--KEISKPVVTSSRR 491
            :|..                 |:||                   :.|:|.  .|..|
  Rat   237 LRNH-----------------ERSH-------------------TGERPFLCSECGK-------- 257

  Fly   492 NGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIE 556
                                                |.||.|     ||...:||
  Rat   258 ------------------------------------SFSRSS-----SLTCHQRI---------- 271

  Fly   557 IDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATK 621
                              :....|.:|..|.|..:..||.|.|.|||:||:||.|..|||.|:..
  Rat   272 ------------------HAAQKPYRCPACGKGFTQLSSYQSHERTHSGEKPFLCPRCGRMFSDP 318

  Fly   622 GNLKAHMSIHK-IKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERL 685
            .:.:.|...|: :||     ::|..|.:.|.....|..|.|:||.|
  Rat   319 SSFRRHQRAHEGVKP-----YRCEKCGKDFRQPADLAMHRRVHTGD------------------- 359

  Fly   686 GIEDQNSNKSLGTSDTL----DFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATAT 746
                 ...|.|....|.    |.......|||||....:             :..|..:..|:.|
  Rat   360 -----RPFKCLQCDKTFVASWDLKRHALVHSGQRPFRCE-------------ECGRAFAERASLT 406

  Fly   747 PHPLERERDREKERERRIPNDCS--------------DERSHSNPDLTGGRSESGEMPAMDLSSP 797
            .|      .|....||  |..|:              .||:|.:.:.||.      .|..:|
  Rat   407 KH------SRMHSGER--PFHCNACGKSFVVLSSLRKHERTHRSNETTGA------APQQEL--- 454

  Fly   798 SSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPL 862
                  :....|..|..|.||   ..|:.|.                 .:|.|          |.
  Rat   455 ------VLGLALPVGVVGEGS---AAPVAGA-----------------GIGDA----------PA 483

  Fly   863 GFMGLHPPPNVCNLCFKMLPSLAALESH---LQSEHAKEPATGHAQRPQCSDAGSPYGAKLTLNP 924
            |.:||.|...          |:.|.:..   :..||.           :|.|||
  Rat   484 GLLGLPPESG----------SVVATQWQVVGMTVEHV-----------ECQDAG----------- 516

  Fly   925 NLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSN 989
                   ...:.|:.|:                                    |||..|......
  Rat   517 -------VGEAPSTLGD------------------------------------AGEVGGEETDEK 538

  Fly   990 YPQ----EAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDP-PVNNKHFCHVCRRNF 1049
            .||    |..:...:|..::.|....|                  .|.| |      |..|.::|
  Rat   539 PPQFVCRECKETFSTLTLLRRHERSHP------------------ELRPFP------CTQCGKSF 579

  Fly  1050 SSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTH 1090
            |..:.|:.|.|||:..:|:.|:.|.|||.:..:|:.|..||
  Rat   580 SDRAGLRKHSRTHSSVRPYSCSQCPKAFLSASDLRKHERTH 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	10/21 (48%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	14/24 (58%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	595..620	CDD:290200	15/24 (63%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		C2H2 Zn finger	643..663	CDD:275368	6/19 (32%)
		lambda-1	1013..>1061	CDD:212564	9/48 (19%)
		zf-C2H2	1040..1062	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/19 (37%)
Zfp668	XP_017444703.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000