DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Sall2

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001100732.1	Gene:	Sall2 / 305854	RGDID:	1309272	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	1194	Identity:	281/1194 - (23%)
Similarity:	420/1194 - (35%)	Gaps:	397/1194 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SNNN-GTEPQMEAEAVPE-SDTERETAEERGEEQEPE-------NSNEALDLSLISSGGRESLPG 109
            ||:: .:.|:.|..:.|: .|||.....:.|....|:       ...|:....|::..|..:..|
  Rat    73 SNSSVSSVPRPEGHSRPQVMDTEHSNLPDSGSSGPPDPAWGSERRGEESSGQFLVAGTGTAAGGG 137

  Fly   110 SGHVSLEALQHTKVAVAQFAAT--------------------AMAGNHQSADLAMVQSTIFNVQR 154
            .|.:         :|..:..||                    .:...|.:..|.:.:..:  :|:
  Rat   138 GGLI---------LASPKLGATPLPPESTPAPPPPPPPPPPPGVGSGHLNIPLILEELRV--LQQ 191

  Fly   155 QHLMQLQLIQHLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQ 219
            :.:.|:|:.:.:..|:     ..||  |..........|...|.....:..|..|.|....:..|
  Rat   192 RQIHQMQMTEQICRQV-----LLLG--SLGQTVGAPASPSELPGTGTASSTKPLLPLFSPIKPAQ 249

  Fly   220 DQESRREENSKTDKRGTEDRKA------EPEGYQSMMCDISSSLASSIITNHDPPPAPNEPNCLE 278
            ..::....:|.:...|.|..|.      .|.|.|....      ...:..:|.|.|||:     .
  Rat   250 TGKTLASSSSSSSSSGAEPPKQAFFHLYHPLGSQHPFS------VGGVGRSHKPTPAPS-----P 303

  Fly   279 MLQRRTEEVLDS------------ASQSLHAAQMQEE-----------------YSEYASKEAQS 314
            .|...|::::.|            |:|.|.||:..|.                 |.|..|...:.
  Rat   304 ALPGSTDQLIASPHLAFPGTTGLLAAQCLGAARGLEAAASPGLLKPKNGSGELGYGEVISSLEKP 368

  Fly   315 RGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPML 379
            .|   :|:|::|.|:|||.|||||||||||||||:.|||||::|||:||||||:.||.:.:|.:.
  Rat   369 GG---RHKCRFCAKVFGSDSALQIHLRSHTGERPYKCNVCGNRFTTRGNLKVHFHRHREKYPHVQ 430

  Fly   380 LPPGVAPN-----VGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAE 439
            :.|...|.     :..||            ||:...|             .||:..:|...|...
  Rat   431 MNPHPVPEHLDYVITSSG------------LPYGMSV-------------PPEKAEEEAATPGGG 470

  Fly   440 DLSKPMVKEKE--KSHSPVERVKTPKEVKTDAALPSSEK--------PEKEISK--------PVV 486
            ...||:|....  .:...:..:.|.........||:..|        |:.::.:        ..:
  Rat   471 VERKPLVASTTALSATESLTLLSTGTSTAVAPGLPTFNKFVLMKAVEPKSKVDENTPPGSEGSAI 535

  Fly   487 TSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSW 551
            :....:||..:.|.|           .||..|....|:.....|..|.|..|.|..:..
  Rat   536 SGVADSGSATRMQLS-----------KLVTSLPSWALLTNHLKSTGSFPFPYVLEPLGA------ 583

  Fly   552 EDLIEIDKTSETSKLQQLVDNIE-----------------------NKLTDPNQCIFCQKVMSCR 593
                   ..||||||||||:.|:                       :..:.||||:.|.:|:||.
  Rat   584 -------SPSETSKLQQLVEKIDRQGAVAVASTASGAPTTSAPAPSSSASGPNQCVICLRVLSCP 641

  Fly   594 SSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQ 658
            .:|::|...|.|||||:||:|||||:|:|||:||...||..|..|:|..||:|.:||:|.:.|||
  Rat   642 RALRLHYGQHGGERPFKCKVCGRAFSTRGNLRAHFVGHKTSPAARAQNSCPICQKKFTNAVTLQQ 706

  Fly   659 HIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGD 723
            |:|:|.     ||| .|.......|..|:..:||:                    ::|.:|..|.
  Rat   707 HVRMHL-----GGQ-IPNGGSTLPEGGGVAQENSS--------------------EQSTASGPGS 745

  Fly   724 FDEFMTMDSTDDSRDNSSAATATPHP------LERERDREKERERRIPNDCSDERSHSNPDLTGG 782
            |                      |.|      .|.|...|:|.:.....|.:||.|     |.|.
  Rat   746 F----------------------PQPQAQQPSAEEEISEEEEEDEEEEEDVTDEDS-----LAGR 783

  Fly   783 RSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHAL 847
            .||||...|:.:...|..         .:||....:.:|..|..|..:..|    ..|.::
  Rat   784 GSESGGEKAISVRGDSEE---------VSGAEEEAATSGAAPTNGKEVDNN----EKATQQ---- 831

  Fly   848 GHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDA 912
                              .|.|||                           |...:..|||..:.
  Rat   832 ------------------ALPPPP---------------------------PPPDNLDRPQPMEQ 851

  Fly   913 GSPYGAKLTLNPNLFAKKPPSSSSSSSGE--KLPESSNP--PFPAENPPATPIKEDPDQEQLMVE 973
            |                  ||..|....|  ||..:|:|  ..|.|
  Rat   852 G------------------PSDVSGGMEEEAKLEGTSSPMAALPQE------------------- 879

  Fly   974 EGASAGEGSGTGATS--NYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPV 1036
                 |||:.|.:..  |.|:                             .|...|..||
  Rat   880 -----GEGTSTPSVEELNLPE-----------------------------AMKKEPGESS----- 905

  Fly  1037 NNKHFCHVCRRNFSSSSALQIHMRTHTGDKP-FQCNVCQKAFTTKGNLKVHM-GTHMWTNPTSRR 1099
             ::..|.||.::|.:.:||:.|.:||..|.| |.|..|::.|..:..||.|| ..|....|.:..
  Rat   906 -SRKACEVCGQSFPTQTALEEHQKTHPKDGPLFTCVFCRQGFLDRATLKKHMLLAHHQVPPFAPH 969

  Fly  1100 GRRMSLELPMRPGPNSGQGHPGSS 1123
            |.:....|.:.||.:|....||.|
  Rat   970 GPQNIATLSLVPGCSSSIPSPGLS 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	15/21 (71%)
		C2H2 Zn finger	323..343	CDD:275368	14/19 (74%)
		zf-H2C2_2	335..360	CDD:290200	20/24 (83%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	595..620	CDD:290200	15/24 (63%)
		C2H2 Zn finger	611..631	CDD:275368	13/19 (68%)
		C2H2 Zn finger	643..663	CDD:275368	11/19 (58%)
		lambda-1	1013..>1061	CDD:212564	11/47 (23%)
		zf-C2H2	1040..1062	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	11/25 (44%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/20 (35%)
Sall2	NP_001100732.1	C2H2 Zn finger	374..394	CDD:275368	14/19 (74%)
		zf-H2C2_2	386..411	CDD:290200	20/24 (83%)
		C2H2 Zn finger	402..422	CDD:275368	14/19 (74%)
		C2H2 Zn finger	631..651	CDD:275368	7/19 (37%)
		zf-H2C2_2	643..668	CDD:290200	15/24 (63%)
		C2H2 Zn finger	659..679	CDD:275368	13/19 (68%)
		zf-C2H2	690..711	CDD:278523	11/20 (55%)
		C2H2 Zn finger	691..711	CDD:275368	11/19 (58%)
		C2H2 Zn finger	910..930	CDD:275368	7/19 (37%)
		zf-C2H2	910..930	CDD:278523	7/19 (37%)
		C2H2 Zn finger	939..957	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45072
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.810