DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Zfp536

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_008757491.2	Gene:	Zfp536 / 292820	RGDID:	1563363	Length:	1383	Species:	Rattus norvegicus

Alignment Length:	1095	Identity:	221/1095 - (20%)
Similarity:	362/1095 - (33%)	Gaps:	347/1095 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 QHLMQLQLIQHLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQ 219
            |:.|. |.:..:.|||..|              ..|..|.|.|:::|...|:|:..:
  Rat    29 QYAMS-QKLHQITSQLSHA--------------FPELHPRPNPEEKPPAALEEKAHV-------- 70

  Fly   220 DQESRREENSKTDKRGTEDRKAEPEGYQSMMCDISSSLASSIITNHDPPPAPNEPNCLEMLQRRT 284
                                   |...|||    .|.:|  ::.|.......|..|....||:..
  Rat    71 -----------------------PMSGQSM----GSQMA--LLANQLGRDVDNSLNGRVDLQQFL 106

  Fly   285 EEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPF 349
            .      .|:|.......:..:.|.|..       |:.|..|||.|...|.|.:|:|:||||:||
  Rat   107 N------GQNLGIMSQMSDIEDDARKNR-------KYPCPLCGKRFRFNSILSLHMRTHTGEKPF 158

  Fly   350 VCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLPFAPPVAPV 414
            .|..|..:...|||||:|.:.|.            ..|:| .|:|:|:.|...:
  Rat   159 KCPYCDHRAAQKGNLKIHLRTHK------------LGNLG-KGRGRVREENRLL----------- 199

  Fly   415 GQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPSSEKPEK 479
             .|..:..:...::::..:..|:: || ||:...::...:.......|.....|.|.|:......
  Rat   200 -HELEERAILRDKQMKGSLLQPRS-DL-KPLAHAQQAPLATCNLTLPPNHSVPDVAHPAPSPKPA 261

  Fly   480 EISKPVVTSSRR------NGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEY 538
            .:.:..||.:..      .|..:||:             :|..|:.|.....:.:.      .::
  Rat   262 NLQEDSVTPAAGFRCTFCKGKFKKRE-------------ELDRHIRILHKPYKCTL------CDF 307

  Fly   539 SLAQMERIIDKSWEDLIEIDK---TSETSKLQQLVDNIENKLTDPN----------QCIFCQKVM 590
            :.:|.|.:|.       .::|   |:|:::.|           .||          :|..|.:|.
  Rat   308 AASQEEELIS-------HVEKAHITAESAQGQ-----------GPNGGGEQSANEFRCEVCGQVF 354

  Fly   591 SCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIH------KIKPPMRSQFKCPVCHQK 649
            |....|:.|:|.|.......|:||||.|.....||.||.:|      |.|.|...:...|:
  Rat   355 SQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPTEPEVSVPM---- 415

  Fly   650 FSNGIILQQHIRIHT----------MDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDF 704
              .|:..:.|..:::          |.........|:...|:.|....|.:...|.|....::..
  Rat   416 --GGLSQEAHANLYSRYLSCLQSGFMAPDKASLNEPSQLYGKGELPAKEKEVLGKLLSPISSMAH 478

  Fly   705 STTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHP-------------------- 749
            |....|      :.|..|..:....:.|:...|..::|..|...|
  Rat   479 SVPEGD------KHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGF 537

  Fly   750 LERERDREKERERRIPN-----DCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGL 809
            |.:|....:..|..:.|     | .::|.:.   |.|......:||| ||         :.:|.:
  Rat   538 LSKEHQLTRNHEDPLANAGVLFD-KEKREYV---LVGADGSKQKMPA-DL---------VHSTKV 588

  Fly   810 ANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVC 874
            .|               ...:|..|..:..:||.:     :|.....|.:...|...:...|..|
  Rat   589 GN---------------QRDLPNKLDPLEGSREFL-----SHGLNQTLEYNLQGPGNMKEKPTEC 633

  Fly   875 NLCFKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPSS---SS 936
            ..|.::..:...:..| ...|.::       |....||       |.:...|..::...|   |.
  Rat   634 PDCGRVFRTYHQVVVH-SRVHKRD-------RKSDEDA-------LHVGVGLEERRGSGSDQESQ 683

  Fly   937 SSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTG------------ATSN 989
            |.|....|.|||                      :.||..:.|..|.||            ::|:
  Rat   684 SVSRSTTPGSSN----------------------VTEESGAGGGLSQTGSAQEDSPHPSSPSSSD 726

  Fly   990 YPQEAGDA----EQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFS 1050
            ..:|||.|    :|:|::               .:.|.||             ...|..|.:.|.
  Rat   727 IGEEAGRAGGVQQQALLR---------------DRNLGSA-------------MKDCPYCAKTFR 763

  Fly  1051 SSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMRPGPNS 1115
            :|..|::|:|.|||:||::|..|..|.|...:||.|:..|       .|.|:..      .||.|
  Rat   764 TSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERH-------HRERQNG------AGPLS 815

  Fly  1116 GQGHPGSSAEQEFMQRRPELFFPYLPPFFNGLPPKPGELSPGAFPNIPPPPFANG 1170
            || .|....:.|...:.|....|              ::..|||..:|...|.:|
  Rat   816 GQ-PPNQEHKDETSSKAPMFIRP--------------DILRGAFKGLPGIDFRSG 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	9/21 (43%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	11/24 (46%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	595..620	CDD:290200	10/24 (42%)
		C2H2 Zn finger	611..631	CDD:275368	10/19 (53%)
		C2H2 Zn finger	643..663	CDD:275368	3/19 (16%)
		lambda-1	1013..>1061	CDD:212564	9/47 (19%)
		zf-C2H2	1040..1062	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/19 (37%)
Zfp536	XP_008757491.2	COG5048	103..>180	CDD:227381	29/89 (33%)
		C2H2 Zn finger	132..152	CDD:275368	9/19 (47%)
		zf-H2C2_2	145..169	CDD:404364	11/23 (48%)
		C2H2 Zn finger	160..180	CDD:275368	8/19 (42%)
		C2H2 Zn finger	276..297	CDD:275368	6/33 (18%)
		C2H2 Zn finger	302..323	CDD:275368	4/33 (12%)
		zf-C2H2	345..367	CDD:395048	7/21 (33%)
		C2H2 Zn finger	347..367	CDD:275368	7/19 (37%)
		C2H2 Zn finger	375..395	CDD:275368	10/19 (53%)
		zf-C2H2_assoc	657..739	CDD:406903	24/110 (22%)
		C2H2 Zn finger	755..775	CDD:275368	7/19 (37%)
		zf-C2H2	755..775	CDD:395048	7/19 (37%)
		zf-H2C2_2	767..789	CDD:404364	10/21 (48%)
		zf-H2C2_5	781..804	CDD:404746	8/29 (28%)
		C2H2 Zn finger	783..803	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910