DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and ZNF875

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_016882161.1	Gene:	ZNF875 / 284459	HGNCID:	4928	Length:	704	Species:	Homo sapiens

Alignment Length:	972	Identity:	181/972 - (18%)
Similarity:	265/972 - (27%)	Gaps:	463/972 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 IFNVQR---QHLMQLQLIQHLQSQLKRAEAAALGRHSHSDEEEEEPEP-----------EPEPK- 198
            ||:.|:   ||:. |..:..|.|.|.......||:| :.::::::.:|           |.|..
Human   164 IFSSQQALSQHVW-LSHLSQLFSSLWAGNPLHLGKH-YPEDQKQQQDPFCFSGKAEWIQEGEDSR 226

  Fly   199 ----KQPTNGLKEELELEQGPESEQDQESRREENSKTDKRGTEDRKAEPEGYQSMMCDISSSLAS 259
                :...||..:.|   ..|..||.....:|:|:..|...:.:|:|:.|....::..:..|...
Human   227 LLFGRVSKNGTSKAL---SSPPEEQQPAQSKEDNTVVDIGSSPERRADLEETDKVLHGLEVSGFG 288

  Fly   260 SIITNHDPPPAPNEPNCLEMLQRRTEEVLDSASQSLHAAQMQEEYSE--------YASKEAQSRG 316
            .|......|....|.|.|.:.:.:|.|          ...|..|:.:        ..:....|.|
Human   289 EIKYEEFGPGFIKESNLLSLQKTQTGE----------TPYMYTEWGDSFGSMSVLIKNPRTHSGG 343

  Fly   317 EIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLP 381
            :  .:.|:.||:.|...|.|..|.|:|:||:|:||..||..||.|.||..|.:.|:
Human   344 K--PYVCRECGRGFTWKSNLITHQRTHSGEKPYVCKDCGRGFTWKSNLFTHQRTHS--------- 397

  Fly   382 PGVAPNVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMV 446
             |:.|.|                                                         .
Human   398 -GLKPYV---------------------------------------------------------C 404

  Fly   447 KEKEKSHSPVERVKTPKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRE 511
            ||..:|.|....:.|.:...|.             .||.|.                      ||
Human   405 KECGQSFSLKSNLITHQRAHTG-------------EKPYVC----------------------RE 434

  Fly   512 --RDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIE 574
              |...:|.|:.:..|..|..:
Human   435 CGRGFRQHSHLVRHKRTHSGEK------------------------------------------- 456

  Fly   575 NKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHK-IKPPMR 638
                 |..|..|::..|.:|.|..|:||||||:|:.|..|||.|:.|.|||.|...|. :||
Human   457 -----PYICRECEQGFSQKSHLIRHLRTHTGEKPYVCTECGRHFSWKSNLKTHQRTHSGVKP--- 513

  Fly   639 SQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLD 703
              :.|..|.|.||....|.:|.|.||               ||...:
Human   514 --YVCLECGQCFSLKSNLNKHQRSHT---------------GEKPFV------------------ 543

  Fly   704 FSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDC 768
                                        .|:..|..:..:|.:.|
Human   544 ----------------------------CTECGRGFTRKSTLSTH-------------------- 560

  Fly   769 SDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPN 833
              :|:|           |||.|.
Human   561 --QRTH-----------SGEKPF------------------------------------------ 570

  Fly   834 LLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKE 898
                                                   ||..|.:.....:.|.||.::...::
Human   571 ---------------------------------------VCAECGRGFNDKSTLISHQRTHSGEK 596

  Fly   899 PATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKE 963
            |.       .|.:.|..:..|    ||||..|...|
Human   597 PF-------MCRECGRRFRQK----PNLFRHKRAHS----------------------------- 621

  Fly   964 DPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPP 1028
                       ||......|.|..         |:.:|:|.| .||              :.|.|
Human   622 -----------GAFVCRECGQGFC---------AKLTLIKHQ-RAH--------------AGGKP 651

  Fly  1029 TSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTH 1090
                       |.|..|.:.||..|.|..|.|||:|:||:.|..|.:.|:.|.||..|..||
Human   652 -----------HVCRECGQGFSRQSHLIRHQRTHSGEKPYICRKCGRGFSRKSNLIRHQRTH 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	8/21 (38%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..360	CDD:290200	12/24 (50%)
		C2H2 Zn finger	351..371	CDD:275368	9/19 (47%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	595..620	CDD:290200	14/24 (58%)
		C2H2 Zn finger	611..631	CDD:275368	10/19 (53%)
		C2H2 Zn finger	643..663	CDD:275368	8/19 (42%)
		lambda-1	1013..>1061	CDD:212564	10/47 (21%)
		zf-C2H2	1040..1062	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1042..1062	CDD:275368	8/19 (42%)
		zf-H2C2_2	1054..1079	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/19 (37%)
ZNF875	XP_016882161.1	KRAB	77..136	CDD:214630
		C2H2 Zn finger	324..340	CDD:275368	0/15 (0%)
		COG5048	344..703	CDD:227381	142/777 (18%)
		C2H2 Zn finger	348..368	CDD:275368	8/19 (42%)
		C2H2 Zn finger	376..396	CDD:275368	9/19 (47%)
		C2H2 Zn finger	404..424	CDD:275368	5/19 (26%)
		C2H2 Zn finger	432..452	CDD:275368	6/41 (15%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		C2H2 Zn finger	488..508	CDD:275368	10/19 (53%)
		C2H2 Zn finger	516..536	CDD:275368	8/19 (42%)
		C2H2 Zn finger	544..564	CDD:275368	5/41 (12%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		C2H2 Zn finger	600..620	CDD:275368	8/23 (35%)
		C2H2 Zn finger	626..646	CDD:275368	6/29 (21%)
		C2H2 Zn finger	654..674	CDD:275368	8/19 (42%)
		C2H2 Zn finger	682..702	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000