DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and SALL3

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_741996.2	Gene:	SALL3 / 27164	HGNCID:	10527	Length:	1300	Species:	Homo sapiens

Alignment Length:	1363	Identity:	392/1363 - (28%)
Similarity:	547/1363 - (40%)	Gaps:	351/1363 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PQMEAEAVPESDTERETAEERG------------EEQEPENSNEALDLSLISSGGRESLP----- 108
            |:....:.|....|.|.|||.|            :|.||.::..|.|............|
Human    95 PEPSPASSPSERAESEAAEEAGAEGAEGEARPVEKEAEPMDAEPAGDTRAPRPPPAAPAPPTPAY 159

  Fly   109 --GSGHVSLEALQHTKVAVAQFAATAMA-------GNHQSADLAMVQSTIFNVQRQHLMQLQLIQ 164
              .|.:|:||||..||||||||:..|.|       |...:|.:.::...:..:|:|.:.|||||:
Human   160 GAPSTNVTLEALLSTKVAVAQFSQGARAAGGSGAGGGVAAAAVPLILEQLMALQQQQIHQLQLIE 224

  Fly   165 HLQSQL----------KRAEAAALGRHSHSDEEEEEPEPEPEPKKQP-------TNGLKEELELE 212
            .::||:          ..:.|||            ...|.|.|.:.|       :.|........
Human   225 QIRSQVALMQRPPPRPSLSPAAA------------PSAPGPAPSQLPGLAALPLSAGAPAAAIAG 277

  Fly   213 QGPES----EQDQESRREENSKTDKRGTED------RKAEPEGYQSMMCDISSSLASSIITNHDP 267
            .||.:    |..|...|.|:..:...|..:      ..|.|............|.|||...:...
Human   278 SGPAAPAAFEGAQPLSRPESGASTPGGPAEPSAPAAPSAAPAPAAPAPAPAPQSAASSQPQSAST 342

  Fly   268 PPA-------------PNE------------PNCLEMLQRRTEEVLDSASQSL-HAAQMQEEYSE 306
            |||             |:.            ||.|..: ..|...||..|..: |........|.
Human   343 PPALAPGSLLGAAPGLPSPLLPQTSASGVIFPNPLVSI-AATANALDPLSALMKHRKGKPPNVSV 406

  Fly   307 YASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRH 371
            :..| |.:....|||:|::|.|:|||.||||||||||||||||.||:||::|:||||||||:|||
Human   407 FEPK-ASAEDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRH 470

  Fly   372 TQIFPPMLLPPGVAP----NVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQV--EEPEEIR 430
            .:.:|.:.:.|...|    ||     ....|..|.:.|   ||..||........|  ..|..:.
Human   471 KEKYPHIQMNPYPVPEYLDNV-----PTCSGIPYGMSL---PPEKPVTTWLDSKPVLPTVPTSVG 527

  Fly   431 QEIP--VPQAEDLSKPMVKEKEKSHSPVER-VKTPKEVKTDAALPS-------------SEKPEK 479
            .::|  ||.|...:      ...|.:|..| .:.|....::.|..|             :|.|:.
Human   528 LQLPPTVPGAHGYA------DSPSATPASRSPQRPSPASSECASLSPGLNHVESGVSATAESPQS 586

  Fly   480 EISKPVVT---------SSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQP 535
            .:..|.:|         ::.|.|.......::.:|...|.              ..:|......|
Human   587 LLGGPPLTKAEPVSLPCTNARAGDAPVGAQASAAPTSVDG--------------APTSLGSPGLP 637

  Fly   536 A--EYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQM 598
            |  |...||.      .:..|::..:|||||||||||:||:.|:||||||:.|.:|:||:|:|:|
Human   638 AVSEQFKAQF------PFGGLLDSMQTSETSKLQQLVENIDKKMTDPNQCVICHRVLSCQSALKM 696

  Fly   599 HIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIH 663
            |.|||||||||:||||||||.||||||.|..:|:.|||:|.|..||:|.:||:|.::||||||:|
Human   697 HYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLRVQHSCPICQKKFTNAVVLQQHIRMH 761

  Fly   664 TMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFM 728
                 .||| .|               |:....|..|.:|......|.:.:...|     :|:.|
Human   762 -----MGGQ-IP---------------NTPLPEGFQDAMDSELAYDDKNAETLSS-----YDDDM 800

  Fly   729 TMDSTDDSRDNSSAAT------------ATPHP---------LERER------------------ 754
            ..:|.:|..:...|||            ..|.|         ||.:.
Human   801 DENSMEDDAELKDAATDPAKPLLSYAGSCPPSPPSVISSIAALENQMKMIDSVMSCQQLTGLKSV 865

  Fly   755 DREKERERRIPNDCS------DERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGA 813
            :.......|:.||.|      :.||..:|.|    |||....|:   ||:.::|..|
Human   866 ENGSGESDRLSNDSSSAVGDLESRSAGSPAL----SESSSSQAL---SPAPSNGESF-------- 915

  Fly   814 AGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHAL----GHAHAKFPLLPFGPLGFMGLHP----- 869
                  ....|.||.|..|..:.:...|.:..|.    |.|..:..:....|...:.|..
Human   916 ------RSKSPGLGAPEEPQEIPLKTERPDSPAAAPGSGGAPGRAGIKEEAPFSLLFLSRERGKC 974

  Fly   870 PPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPSS 934
            |..||.:|.|.....:|||.|.:|...:.|......|..||..|:       |..:|...:
Human   975 PSTVCGVCGKPFACKSALEIHYRSHTKERPFVCALCRRGCSTMGN-------LKQHLLTHR---- 1028

  Fly   935 SSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQ 999
                                      :||.|.|   :.:...:.|....|      |.....|..
Human  1029 --------------------------LKELPSQ---LFDPNFALGPSQST------PSLISSAAP 1058

  Fly  1000 SLMKMQLHAH----------------RFPASPLDFQQALMSAGPPTSSLDPP--VNNKHFCHVCR 1046
            :::||:::.|                :.||.|    |.:|..|.......||  ...:|.|..|.
Human  1059 TMIKMEVNGHGKAMALGEGPPLPAGVQVPAGP----QTVMGPGLAPMLAPPPRRTPKQHNCQSCG 1119

  Fly  1047 RNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMRP 1111
            :.|||:||||||.|||||:|||.|.:|.:|||||||||||||||||.|..:|||||:|:|.||
Human  1120 KTFSSASALQIHERTHTGEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPM-- 1182

  Fly  1112 GPNSGQGHPGSSAEQEFMQRR-----PELFFPYLPPFFNGLPPKPGELSPGAFPNIPPPPFANGG 1171
            ....|.....|...|:.:..|     |..:..|.....|||..|..|:|......||..|.:.||
Human  1183 ALLGGDALKFSEMFQKDLAARAMNVDPSFWNQYAAAITNGLAMKNNEISVIQNGGIPQLPVSLGG 1247

  Fly  1172 KYPYPPGLLGFPGFLAQHPYILERRSSSKSPTPEPAQSPALREEEGSGNIWHPLSRIKVENNQ 1234
            . ..||     .|.:|..   :::..:..|| |..:...|..|...|    .|.:|. :|:|:
Human  1248 S-ALPP-----LGSMASG---MDKARTGSSP-PIVSLDKASSETAAS----RPFTRF-IEDNK 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	15/21 (71%)
		C2H2 Zn finger	323..343	CDD:275368	14/19 (74%)
		zf-H2C2_2	335..360	CDD:290200	20/24 (83%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	10/19 (53%)
		zf-H2C2_2	595..620	CDD:290200	20/24 (83%)
		C2H2 Zn finger	611..631	CDD:275368	15/19 (79%)
		C2H2 Zn finger	643..663	CDD:275368	12/19 (63%)
		lambda-1	1013..>1061	CDD:212564	19/49 (39%)
		zf-C2H2	1040..1062	CDD:278523	13/21 (62%)
		C2H2 Zn finger	1042..1062	CDD:275368	12/19 (63%)
		zf-H2C2_2	1054..1079	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1070..1090	CDD:275368	15/19 (79%)
SALL3	NP_741996.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..162		14/66 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..258		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..352		16/74 (22%)
		COG5048	412..>734	CDD:227381	134/355 (38%)
		C2H2 Zn finger	422..442	CDD:275368	14/19 (74%)
		C2H2 Zn finger	450..470	CDD:275368	14/19 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..633		20/129 (16%)
		C2H2 Zn finger	681..701	CDD:275368	10/19 (53%)
		zf-H2C2_2	693..718	CDD:316026	20/24 (83%)
		C2H2 Zn finger	709..729	CDD:275368	15/19 (79%)
		zf-C2H2	739..761	CDD:306579	12/21 (57%)
		C2H2 Zn finger	741..761	CDD:275368	12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..955		25/111 (23%)
		C2H2 Zn finger	979..999	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1007..1027	CDD:275368	6/26 (23%)
		zf-C2H2	1113..1135	CDD:306579	13/21 (62%)
		C2H2 Zn finger	1115..1135	CDD:275368	12/19 (63%)
		zf-H2C2_2	1127..1152	CDD:316026	17/24 (71%)
		C2H2 Zn finger	1143..1163	CDD:275368	15/19 (79%)
		zf-C2H2	1143..1163	CDD:306579	15/19 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1259..1279		4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7769
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47594
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm40936
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.890