DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Zfp709

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_006252902.1	Gene:	Zfp709 / 266773	RGDID:	628698	Length:	765	Species:	Rattus norvegicus

Alignment Length:	1027	Identity:	212/1027 - (20%)
Similarity:	326/1027 - (31%)	Gaps:	389/1027 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 FNVQRQHLM---QLQLIQHLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEE-LE 210
            |.|:...|:   |.:|.:.:..:..| ..||:|:   :.|::...:.....::...||:.|. ||
  Rat    49 FTVEEWALLGPSQKKLHRDVMEETFR-NLAAIGK---TQEDQNIDDDHRYSRRNQRNGVVERLLE 109

  Fly   211 LEQGPESEQDQESRREENSKTDKRGTEDRK--AEPEGYQSMMCDISSSLASSI--ITNHDPP--- 268
            ..:|.|.   :...|:....|..|.|..|.  .|...|:..|....:||..|:  .|.|.||
  Rat   110 HRKGCEC---KAIFRQIPDTTGNRKTSHRTVLCENHVYKDNMLISHASLNVSVPLQTAHKPPAYE 171

  Fly   269 -------------PAPNEPNCLEMLQRRTEEVLDSASQSLHAAQ----------MQEEYSEYASK 310
                         .|...|.||     ...|..||..:|....|          :|...|:...:
  Rat   172 LCGENLYTFGECEKAFIYPECL-----LKHEDSDSRQRSCEFNQCGKIFKSSDHIQMRVSDETRE 231

  Fly   311 E---AQSRGEIF-----------------KHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCG 355
            |   ::..|:.|                 .:.||.|||.|...|.::.|.|:||||:|:.||.|.
  Rat   232 EMCISKQHGDAFPYPDFLQYVEKIYTGKKPYACKQCGKTFSFLSNIRRHERTHTGEKPYRCNTCD 296

  Fly   356 SKFTTKGNLKVHYQRHTQIFPPMLLPPGVA----PNV-----GHSGQG----QVQGEQYPIRLPF 407
            ..||...|.:.|.:.||...|.:....|.|    .|:     .|:|:.    .:.|:.:.....|
  Rat   297 KAFTCLTNFQEHERTHTGEKPYLCTQCGKAFSFLSNIRRHERTHTGEKPYRCNICGKAFSYLTNF 361

  Fly   408 APPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMV-KEKEKSHSPVERVKTPKEVKTDAAL 471
                    |:..:....|                 ||.| .:..|:.:.....:|.|...|
  Rat   362 --------QDHERTHTGE-----------------KPYVCTQCGKAFTYYYSFQTHKRCHT---- 397

  Fly   472 PSSEKPE--KEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQ 534
              .|||.  |:..|  ..|...:....||..:...|             ::.||..::..:..
  Rat   398 --GEKPYVCKQCGK--AFSYYNSIQTHKRCHTGEKP-------------YVCKLCEKAFTTLS-- 443

  Fly   535 PAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMH 599
                ||...|||  .|.|                          .|:.|:.|.|..:..|:|::|
  Rat   444 ----SLRYHERI--HSGE--------------------------KPHVCLQCGKGFNSSSTLRIH 476

  Fly   600 IRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHT 664
            .||||||:|::||.||:.|:...:|:.|..||..:.|    :.|..|.:.|:....|:.|.|||.
  Rat   477 ERTHTGEKPYKCKQCGKVFSVDSSLRCHERIHSGEKP----YVCKQCGKAFTRHTSLRCHERIHC 537

  Fly   665 MDDGSGGQGAPAANPGEAERLG---IEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQ--GGDF 724
                       ...|.:.::.|   |...|..|...|            |||::....:  |..|
  Rat   538 -----------GEKPYKCKQCGKGFISSSNFRKHEWT------------HSGEKHCVCKLCGKAF 579

  Fly   725 DEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSNPDLTGGRSESGEM 789
                                 |.|                    |..|.|.       |..|||.
  Rat   580 ---------------------TGH--------------------SSLRRHE-------RIHSGEK 596

  Fly   790 PAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKF 854
            |.:     ..:.|:.|::                            |....|.|....|.
  Rat   597 PYV-----CKHCGKGFSS----------------------------LSGCQRHEQIHTGE----- 623

  Fly   855 PLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPY--G 917
                           .|:||..|.|...:.:||.:|.:....::|..       |...|..:  .
  Rat   624 ---------------KPHVCKSCGKAFTNPSALRNHERIHSGEKPCI-------CEQCGKGFISF 666

  Fly   918 AKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGS 982
            :|..::..:           .:|||       |:..:                      ..|: :
  Rat   667 SKFRIHERI-----------HTGEK-------PYKCK----------------------QCGK-A 690

  Fly   983 GTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRR 1047
            .||.:|....|           ::|:...|                           ..|..|.:
  Rat   691 FTGHSSLRRHE-----------RIHSGEKP---------------------------FVCKQCGK 717

  Fly  1048 NFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRR 1099
            :|.:.|..|.|.:.|||:|||.|..|.||||...:||:|..||      |||
  Rat   718 SFYTLSDCQRHEQIHTGEKPFICKQCGKAFTRSSSLKIHEKTH------SRR 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	9/21 (43%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	11/24 (46%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	595..620	CDD:290200	14/24 (58%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	643..663	CDD:275368	6/19 (32%)
		lambda-1	1013..>1061	CDD:212564	6/47 (13%)
		zf-C2H2	1040..1062	CDD:278523	6/21 (29%)
		C2H2 Zn finger	1042..1062	CDD:275368	6/19 (32%)
		zf-H2C2_2	1054..1079	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1070..1090	CDD:275368	9/19 (47%)
Zfp709	XP_006252902.1	KRAB	40..>80	CDD:214630	8/31 (26%)
		KRAB	40..79	CDD:279668	7/30 (23%)
		COG5048	<196..356	CDD:227381	40/159 (25%)
		C2H2 Zn finger	240..256	CDD:275368	2/15 (13%)
		C2H2 Zn finger	264..284	CDD:275368	9/19 (47%)
		zf-H2C2_2	276..301	CDD:290200	11/24 (46%)
		COG5048	288..730	CDD:227381	133/735 (18%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	304..328	CDD:290200	7/23 (30%)
		C2H2 Zn finger	320..340	CDD:275368	3/19 (16%)
		zf-H2C2_2	332..357	CDD:290200	4/24 (17%)
		C2H2 Zn finger	348..368	CDD:275368	3/27 (11%)
		zf-H2C2_2	360..385	CDD:290200	7/49 (14%)
		C2H2 Zn finger	376..396	CDD:275368	3/19 (16%)
		zf-H2C2_2	388..413	CDD:290200	8/32 (25%)
		C2H2 Zn finger	404..424	CDD:275368	5/21 (24%)
		C2H2 Zn finger	432..452	CDD:275368	7/27 (26%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		zf-H2C2_2	473..496	CDD:290200	13/22 (59%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		zf-H2C2_2	500..525	CDD:290200	8/28 (29%)
		C2H2 Zn finger	516..536	CDD:275368	6/19 (32%)
		zf-H2C2_2	528..551	CDD:290200	7/33 (21%)
		C2H2 Zn finger	544..564	CDD:275368	5/31 (16%)
		C2H2 Zn finger	572..592	CDD:275368	8/67 (12%)
		zf-H2C2_2	584..609	CDD:290200	9/36 (25%)
		C2H2 Zn finger	600..620	CDD:275368	5/47 (11%)
		zf-H2C2_2	614..637	CDD:290200	8/42 (19%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		C2H2 Zn finger	656..676	CDD:275368	3/30 (10%)
		zf-H2C2_2	669..692	CDD:290200	5/63 (8%)
		C2H2 Zn finger	684..704	CDD:275368	5/53 (9%)
		zf-H2C2_2	696..721	CDD:290200	7/62 (11%)
		C2H2 Zn finger	712..732	CDD:275368	6/19 (32%)
		zf-H2C2_2	724..749	CDD:290200	13/24 (54%)
		C2H2 Zn finger	740..760	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000