DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment salr and Zfp334

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_006499440.1	Gene:	Zfp334 / 228876	MGIID:	2388656	Length:	690	Species:	Mus musculus

Alignment Length:	972	Identity:	185/972 - (19%)
Similarity:	294/972 - (30%)	Gaps:	381/972 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 HLMQLQLIQHLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQD 220
            |:.:..:|..|:...:......|.|.:|:    |:.||..:.||.....||:...:...|..|:.
Mouse    61 HVSKPDVILKLEQGKEPWVVENLSRQNHA----EDDEPLEKDKKTQDKHLKQFSVVNSKPMLEKA 121

  Fly   221 QESRREE--NSKTDKRGTEDRKAEPEGYQSMMCDISSSLA------SSIITNHDPPPAPNEPNCL 277
            ..|.:..  |..:...|....|.:|.| ..:..:...::|      ..:..:.|   ...:|...
Mouse   122 NLSEKTVPLNMNSVSSGKTLHKYDPGG-NGLENNSEKTIAKPSKANGKVAADQD---GRGKPALH 182

  Fly   278 EMLQR--------RTEEVLDSASQSLHAAQMQ-----EEYSEYASKEAQSRG--------EIFKH 321
            ....|        |..||.|...|.....|.|     .:.||:...|.:|.|        |..::
Mouse   183 TKADRSHSAAKRYRRNEVRDVKGQGEGLTQQQNTQSASQPSEHREGEQESAGAARSEEQPERKRN 247

  Fly   322 RCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVA- 385
            .|..|.|.|...|.|.:|||.||||||:.||.|...|..|.:|..|.:.||...|......|.|
Mouse   248 ECAECRKTFSKRSTLIVHLRIHTGERPYACNYCRKTFRIKASLTRHQRIHTGERPYKCKECGKAF 312

  Fly   386 ----PNVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMV 446
                ..:.|.   ::.|                |::.:     |..|..:..       ..|..:
Mouse   313 IDKSALIVHQ---RIHG----------------GEKSY-----ECNECGKTF-------FRKSAL 346

  Fly   447 KEKEKSHSPVERVKTPKEVKTDAALPSSEKPE--KEISKPVVTSSRRNGSVRKRQTSAVSPPQED 509
            .|..:||                   :.|||.  ||...   ...:::..:..::|.....|.|.
Mouse   347 AEHFRSH-------------------TGEKPYKCKECGN---AFGKKSYLIVHQRTHRGEKPNEC 389

  Fly   510 RERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIE 574
            :|        ..|.....||          |...:||            .|.|
Mouse   390 KE--------CGKTFFCLSA----------LTAHQRI------------HTGE------------ 412

  Fly   575 NKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRS 639
                .|.:|..|.|...|:|:|.:|:|:||||:|::|::||:...||..|.||..||:.|    .
Mouse   413 ----KPYECKECDKTFFCQSALNVHLRSHTGEKPYKCRLCGKYLCTKSALVAHQVIHRGK----K 469

  Fly   640 QFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDF 704
            .|:||.|.:.|.....|..|.|.||                 .|:.|:..:.|.
Mouse   470 TFECPECGKLFYLKSTLTIHQRTHT-----------------GEKHGLLSKWSR----------- 506

  Fly   705 STTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCS 769
                                                 |:.|.|:..|::|...|:.    .::|.
Mouse   507 -------------------------------------ASAAKPNCSEQKRADAKDN----VHECH 530

  Fly   770 DERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNL 834
            |.:                       .|:..|.|.|
Mouse   531 DHK-----------------------RPAHKSSRRF----------------------------- 543

  Fly   835 LLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEP 899
                           ||.:            .:...|..|..|.:.....:||..| |..|
Mouse   544 ---------------AHKR------------TIWERPYECEECGRTYCRKSALRHH-QKTH---- 576

  Fly   900 ATGHAQRP-QCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKE 963
             ||  :|| :|.:.|..:..|::...:         ..:.:|||
Mouse   577 -TG--ERPYECKECGKTFCQKVSFTEH---------QRTHTGEK--------------------- 608

  Fly   964 DPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPP 1028
                                       |.:..:..:|.      .|:   |.....:.:.:...|
Mouse   609 ---------------------------PHKCKECGKSF------RHK---SAFTVHKRIHTGEKP 637

  Fly  1029 TSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTH 1090
                       :.|:.|.:::.....|..|.:.|||:||::||:|:|:|..|.|..:|..||
Mouse   638 -----------YACNECGKSYRRLWTLTEHQKIHTGEKPYECNLCKKSFRHKSNFLLHQKTH 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	9/21 (43%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	14/24 (58%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	595..620	CDD:290200	11/24 (46%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	6/47 (13%)
		zf-C2H2	1040..1062	CDD:278523	4/21 (19%)
		C2H2 Zn finger	1042..1062	CDD:275368	4/19 (21%)
		zf-H2C2_2	1054..1079	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1070..1090	CDD:275368	8/19 (42%)
Zfp334	XP_006499440.1	KRAB	20..79	CDD:214630	3/17 (18%)
		C2H2 Zn finger	249..269	CDD:275368	9/19 (47%)
		COG5048	273..689	CDD:227381	134/752 (18%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..325	CDD:275368	3/22 (14%)
		C2H2 Zn finger	333..353	CDD:275368	3/26 (12%)
		C2H2 Zn finger	361..381	CDD:275368	2/22 (9%)
		C2H2 Zn finger	389..409	CDD:275368	7/49 (14%)
		C2H2 Zn finger	417..437	CDD:275368	8/19 (42%)
		C2H2 Zn finger	445..465	CDD:275368	8/19 (42%)
		C2H2 Zn finger	473..493	CDD:275368	7/19 (37%)
		C2H2 Zn finger	556..576	CDD:275368	6/20 (30%)
		C2H2 Zn finger	584..604	CDD:275368	3/28 (11%)
		C2H2 Zn finger	612..632	CDD:275368	3/28 (11%)
		C2H2 Zn finger	640..660	CDD:275368	4/19 (21%)
		C2H2 Zn finger	668..688	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000