DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Zfp62

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001349654.1	Gene:	Zfp62 / 22720	MGIID:	99662	Length:	914	Species:	Mus musculus

Alignment Length:	1128	Identity:	214/1128 - (18%)
Similarity:	351/1128 - (31%)	Gaps:	437/1128 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 RETAEERGEEQEPENSNEALDLSLISSGGRESLPGSGHVSLEALQHTKVAVAQFAATAMAGNHQS 139
            :.|.|:  ||...:|.|:        |......|..|....:.:|.:|..             .:
Mouse     5 KTTMED--EESSKKNEND--------SNADSQCPSVGFFHKDHMQKSKTG-------------DT 46

  Fly   140 ADLAMVQSTIFNVQRQHLMQLQLIQHLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPKK--QPT 202
            .||              ..:.::::..:|.::.    .:..|:::...:.|.:.|...|.  ..|
Mouse    47 CDL--------------FPKWKILKEGKSSIRE----MIDTHTNAANIKLEQDDETSEKSFYPST 93

  Fly   203 NGLKEELELE-----QGPESEQ-----------DQESRR-EENSKTDKRGTE--DRKAEPEGYQS 248
            |.:.:.:..|     ||..:|.           |::..: :|..|:.|..:.  ..|....|.:.
Mouse    94 NTMHQTIPTEPNCTKQGEHTENINGNVHPAHIADKKLHKCDECGKSFKYNSRLVQHKIMHTGEKR 158

  Fly   249 MMCD-------ISSSLA------------------------SSIITNHDPPPAPNEPNCLEMLQR 282
            ..||       .||||.                        ||:| ||....: .|.||
Mouse   159 YECDDCRGTFRSSSSLRVHKRIHTGEKPYKCDECGKAYMSYSSLI-NHKSTHS-GEKNC------ 215

  Fly   283 RTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGER 347
                ..|...:|.:.:.:.:::....:.|.       .:.|..|||.|.:.|.|::|.|.||||:
Mouse   216 ----KCDECGKSFNYSSVLDQHKRIHTGEK-------PYECGECGKAFRNSSGLRVHKRIHTGEK 269

  Fly   348 PFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLPFAPPVA 412
            |:.|:.||..|:....|:||.:.||                         ||:     |:
Mouse   270 PYECDTCGKTFSNSSGLRVHKRIHT-------------------------GEK-----PY----- 299

  Fly   413 PVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMV--------------------KEKEKSHSPVE 457
                                    :.::..|..:                    .|.|||.:...
Mouse   300 ------------------------ECDECGKAFITCRTLLNHKSIHFGDKPYKCDECEKSFNYSS 340

  Fly   458 RVKTPKEVKTDAALPSSEKPEK--EISKPVVTSSRRNGS---VRKRQTSAVSPPQED---RERDL 514
            .:...|.:.|      .|||.:  |..|     :.||.|   |.||..:...|.:.|   :....
Mouse   341 LLIQHKVIHT------GEKPYECDECGK-----AFRNSSGLIVHKRIHTGEKPYKCDICGKAFSY 394

  Fly   515 VEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTD 579
            ...|.:.|.:.....:.|.:....|.         |:..|:...||..|.:             .
Mouse   395 SSGLAVHKSIHPGKKAHECKDCGKSF---------SYNSLLLQHKTIHTGE-------------R 437

  Fly   580 PNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCP 644
            |..|..|.|.....|.|::|.|.||||:|::|.:||:|:.::.:||.|..||..:.|    :||.
Mouse   438 PYVCDVCGKTFRNNSGLKVHRRLHTGEKPYKCDVCGKAYISRSSLKNHKGIHMGEKP----YKCS 498

  Fly   645 VCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTIS 709
            .|.:.|:....|:||.||||.:...|     ....|:|.|       :|..|.....:
Mouse   499 YCEKSFNYSSALEQHKRIHTREKPFG-----CDECGKAFR-------NNSGLKVHKRI------- 544

  Fly   710 DHSGQRS-ESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSD-ER 772
             |:|:|. :..:.|  ..::::.|..:.:        :.||.|:            |..|.: |:
Mouse   545 -HTGERPYKCEECG--KAYISLSSLINHK--------SVHPGEK------------PFKCDECEK 586

  Fly   773 ---------SHSNPDLTGGRSESGEMP-AMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLG 827
                     :|....|       ||.| ..|:...|.|...:.:
Mouse   587 AFITYRTLLNHKKIHL-------GEKPYKCDVCEKSFNYTSLLS--------------------- 623

  Fly   828 MPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQ 892
                            .|...|...|                 |..|:.|.|:..:.::|:.|.:
Mouse   624 ----------------QHKRVHTREK-----------------PFECDRCEKVFRNNSSLKVHKR 655

  Fly   893 SEHAKEPATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPP 957
            ....::|.       :|...|..|                .|.||....|   |::|
Mouse   656 IHTGEKPY-------ECDICGKAY----------------ISHSSLINHK---STHP-------- 686

  Fly   958 ATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLH--------------- 1007
                                       |.||....|.|.|..|...:..|
Mouse   687 ---------------------------GKTSYTCDECGKAFFSSRTLISHKRVHLGEKPFKCVEC 724

  Fly  1008 AHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNV 1072
            ...|..|.|..|...:..|          ...:.|..|.:.|.:||.|.:|.|.|||:||:.|:.
Mouse   725 GKSFSYSSLLSQHKRIHTG----------EKPYVCDWCGKAFRNSSGLTVHKRIHTGEKPYGCDE 779

  Fly  1073 CQKAFTTKGNLKVHMGTHMWTNP 1095
            |:||:.:..:|..|...|....|
Mouse   780 CEKAYISHSSLINHKSVHRGKQP 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	9/21 (43%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	12/24 (50%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	595..620	CDD:290200	12/24 (50%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	11/47 (23%)
		zf-C2H2	1040..1062	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1042..1062	CDD:275368	8/19 (42%)
		zf-H2C2_2	1054..1079	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1070..1090	CDD:275368	6/19 (32%)
Zfp62	NP_001349654.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..101		4/20 (20%)
		COG5048	127..542	CDD:227381	118/541 (22%)
		C2H2 Zn finger	133..153	CDD:275368	4/19 (21%)
		C2H2 Zn finger	161..181	CDD:275368	6/19 (32%)
		C2H2 Zn finger	189..209	CDD:275368	5/20 (25%)
		C2H2 Zn finger	217..237	CDD:275368	2/19 (11%)
		C2H2 Zn finger	245..265	CDD:275368	9/19 (47%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		C2H2 Zn finger	301..321	CDD:275368	1/19 (5%)
		C2H2 Zn finger	329..349	CDD:275368	5/19 (26%)
		C2H2 Zn finger	357..377	CDD:275368	8/24 (33%)
		SFP1	<379..458	CDD:227516	17/100 (17%)
		C2H2 Zn finger	385..405	CDD:275368	3/19 (16%)
		C2H2 Zn finger	413..433	CDD:275368	5/28 (18%)
		COG5048	437..850	CDD:227381	112/544 (21%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		C2H2 Zn finger	525..545	CDD:275368	5/34 (15%)
		C2H2 Zn finger	553..573	CDD:275368	2/29 (7%)
		C2H2 Zn finger	581..601	CDD:275368	3/19 (16%)
		C2H2 Zn finger	609..629	CDD:275368	4/56 (7%)
		C2H2 Zn finger	637..657	CDD:275368	5/19 (26%)
		C2H2 Zn finger	665..685	CDD:275368	8/38 (21%)
		C2H2 Zn finger	693..713	CDD:275368	5/19 (26%)
		C2H2 Zn finger	721..741	CDD:275368	4/19 (21%)
		C2H2 Zn finger	749..769	CDD:275368	8/19 (42%)
		C2H2 Zn finger	777..797	CDD:275368	6/19 (32%)
		C2H2 Zn finger	805..824	CDD:275368
		C2H2 Zn finger	832..852	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910