DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Zfp26

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_011240753.1	Gene:	Zfp26 / 22688	MGIID:	99173	Length:	965	Species:	Mus musculus

Alignment Length:	1117	Identity:	226/1117 - (20%)
Similarity:	348/1117 - (31%)	Gaps:	366/1117 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LAKELDADSNNNGTEPQMEAEAVPESDTERETAEERGEEQEPENSNEALDLSLISSGGRESLPGS 110
            ||.|.|..:.:...|.| :.:||...|...:..:|.....:|...|...|
Mouse    92 LAPEQDFLTRHTFMETQ-QVDAVTFEDVAVDFTQEEWTSLDPVQRNLYRD--------------- 140

  Fly   111 GHVSLEALQHTKVAVAQ-FAATAMAGNHQSADLAMVQSTIFNVQRQHL-MQLQLIQHLQSQLKRA 173
              |.||..|:......| |..:.::...:..:|.:::..|......|| .:...:|..:.....:
Mouse   141 --VMLENYQNLATVGGQMFKPSLISWLEKKVELTVIEQGILQEWEMHLKTKRTALQQDRFWSDMS 203

  Fly   174 EAAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQDQESRREENSKTDKRGT-- 236
            ....||| .||..|..:|                   ::.|....:|  |..:.:|.|...|.
Mouse   204 NGMQLGR-EHSGGEPGDP-------------------VQVGAVFSED--SCPQTHSSTSNTGNTF 246

  Fly   237 -------------EDRKAEPEGYQSMMC--------DISSSLASSIITNHDPPPAPNEPNCLEML 280
                         ::...|....|...|        |:|....:       |..:....:|.|..
Mouse   247 ACNLDGKDFQPLLKETSTEENIVQLNQCVKPLIFTPDVSQKKCT-------PEKSVECSDCGETF 304

  Fly   281 QRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFK-----HRCKYCGKIFGSYSALQIHL 340
            ..:.|....|:|.........||..:.::......|.:..     :.||.|.|.|.....|.||:
Mouse   305 VNQLELQTHSSSHREKNIHKSEECGQASTHPISHGGHVIPTEKKYYECKKCEKFFTHPVYLNIHM 369

  Fly   341 RSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRL 405
            :|||.|:|:.|..||..||.:.:|.||.::||
Mouse   370 QSHTVEKPYDCKECGKAFTERSSLIVHLRQHT--------------------------------- 401

  Fly   406 PFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERVKT---PKEVKT 467
                                                       :|||:...|..||   |..:..
Mouse   402 -------------------------------------------REKSYECKECGKTFIQPSRLTE 423

  Fly   468 DAALPSSEKP-------EKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHL--HIAKL 523
            .....:.|||       ....|...:|:..|..:..|.....:......|...|:.|:  |..:
Mouse   424 HMRSHTGEKPYQCDQCGNAFASSSYLTTHLRTHTGEKPFECNICGKAFTRSSYLLGHIRTHTGE- 487

  Fly   524 VRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQK 588
                      :|.|..:.. :....:||..:.....|.|.                |..|..|:|
Mouse   488 ----------KPYECKVCG-KAFSGRSWLTIHLRKHTGER----------------PYPCTECEK 525

  Fly   589 VMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHK-IKPPMRSQFKCPVCHQKFSN 652
            ..:..:.|..||:|||||:|||||:|.|.|.....||.|..||. |||     :||..|.:.|:.
Mouse   526 AFTSFAQLTEHIKTHTGEKPFRCKVCARTFRNSSCLKTHFRIHTGIKP-----YKCNYCGKAFTA 585

  Fly   653 GIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSE 717
            ...|.:|:.||.           ...|.|.:..|       |:..||..|  ...|..|:|::
Mouse   586 RSGLTKHVLIHN-----------GEKPYECKECG-------KAFSTSSGL--VEHIRIHTGEK-- 628

  Fly   718 SSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSNPDLTGG 782
                                           |.|..:             |....:||:..:...
Mouse   629 -------------------------------PFECYQ-------------CGKALAHSSSLVGHL 649

  Fly   783 RSESGEMP----AMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREE 843
            |:.:||.|    ..|.:...|:..||
Mouse   650 RTHTGEKPFECNQCDKTFTRSSYLRI--------------------------------------- 675

  Fly   844 MHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRP- 907
             |...|...|                 |..|..|.|..|..:.|..|:::.      ||  :||
Mouse   676 -HMRTHTGEK-----------------PYECKECGKTFPERSCLTKHIRTH------TG--ERPY 714

  Fly   908 QCSDAGSPY--GAKLTLNPNLFAKKPP-----------SSSSSSSGEKLPESSNPPFPAENPPAT 959
            :|.:.|..:  .|:||::....:.:.|           :|||..:..::           :....
Mouse   715 ECKECGKGFISFAQLTVHIKTHSSERPFQCKVCTKSFRNSSSLETHFRI-----------HTGVK 768

  Fly   960 PIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDA--EQSLMKMQLHAHRFPASPLDFQ--- 1019
            |.|.....:......|.:....:.||..|...||.|.|  ..|.:...:.:|: ...|.:..
Mouse   769 PYKCSYCGKAFTARSGLTIHLRNHTGEKSYACQECGKAFSTSSGLIAHIRSHK-GEKPFECDHCG 832

  Fly  1020 QALMSAGPPTSSLDPPVNNKHF-CHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNL 1083
            :|..|:......|......|.| |.||.:.|:.||.|.:|||||||:|||||.:|.|:|.....|
Mouse   833 KAFASSSYLNVHLKIHTGEKPFQCTVCGKTFTCSSYLPVHMRTHTGEKPFQCIICGKSFLWSSYL 897

  Fly  1084 KVHMGTHMWTNP 1095
            :|||..|....|
Mouse   898 RVHMRIHTGEKP 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	8/21 (38%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..360	CDD:290200	12/24 (50%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	595..620	CDD:290200	16/24 (67%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	643..663	CDD:275368	5/19 (26%)
		lambda-1	1013..>1061	CDD:212564	15/51 (29%)
		zf-C2H2	1040..1062	CDD:278523	11/22 (50%)
		C2H2 Zn finger	1042..1062	CDD:275368	10/19 (53%)
		zf-H2C2_2	1054..1079	CDD:290200	16/24 (67%)
		C2H2 Zn finger	1070..1090	CDD:275368	8/19 (42%)
Zfp26	XP_011240753.1	KRAB	113..171	CDD:214630	12/74 (16%)
		C2H2 Zn finger	297..317	CDD:275368	4/19 (21%)
		COG5048	325..760	CDD:227381	132/674 (20%)
		C2H2 Zn finger	352..372	CDD:275368	8/19 (42%)
		C2H2 Zn finger	380..400	CDD:275368	8/19 (42%)
		C2H2 Zn finger	408..428	CDD:275368	4/19 (21%)
		C2H2 Zn finger	436..456	CDD:275368	3/19 (16%)
		C2H2 Zn finger	464..484	CDD:275368	3/19 (16%)
		C2H2 Zn finger	492..512	CDD:275368	2/20 (10%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	548..568	CDD:275368	8/19 (42%)
		C2H2 Zn finger	576..596	CDD:275368	5/19 (26%)
		COG5048	600..956	CDD:227381	92/442 (21%)
		C2H2 Zn finger	604..624	CDD:275368	6/28 (21%)
		C2H2 Zn finger	632..652	CDD:275368	4/32 (13%)
		C2H2 Zn finger	660..680	CDD:275368	5/59 (8%)
		C2H2 Zn finger	688..708	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..736	CDD:275368	5/19 (26%)
		C2H2 Zn finger	744..764	CDD:275368	3/30 (10%)
		C2H2 Zn finger	772..792	CDD:275368	1/19 (5%)
		C2H2 Zn finger	800..820	CDD:275368	5/19 (26%)
		C2H2 Zn finger	828..848	CDD:275368	3/19 (16%)
		C2H2 Zn finger	856..876	CDD:275368	10/19 (53%)
		C2H2 Zn finger	884..904	CDD:275368	8/19 (42%)
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..956	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910