DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and sem-4

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_491997.1	Gene:	sem-4 / 172435	WormBaseID:	WBGene00004773	Length:	744	Species:	Caenorhabditis elegans

Alignment Length:	1080	Identity:	253/1080 - (23%)
Similarity:	351/1080 - (32%)	Gaps:	444/1080 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 SRREENSKTDKRGTEDRKAEP-----EGYQSMMCDISSSLA-----SSIITNHDPPPAPNEPNCL 277
            |||:::......|..|....|     :.:....|:..:..|     .|.|..|...|..|....|
Worm    13 SRRKQSKPRRMSGEGDAMMSPIDLSTKSFDENNCEKGAGGALPLEDRSNILPHFSVPFANPQQFL 77

  Fly   278 EMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFKHRC--KYCGKIFGSYSALQIH- 339
            .:                 .||:....|...|..|.:...     |  :.|.:.|.|.:||..|
Worm    78 SL-----------------CAQLGNSSSRNVSSTASTTSS-----CPIQSCSQSFSSPAALTWHV 120

  Fly   340 LRSHTGERP-FVCNVCGSKFTTKGNLKVH------YQRHTQIFPPMLLPPGV-------APNVGH 390
            |.:|..|:. |.|:||.:.|:...:::.|      ..|.|.: ||..:|..|       .|.:..
Worm   121 LDAHEDEQEIFSCDVCTTTFSNGQDIREHKCQKTLASRSTSV-PPSTIPSSVCFLSTPTTPCLQF 184

  Fly   391 S-----GQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEI---PVPQAEDLSKPMVK 447
            |     |..:::.|                .|:....||:.|.:..::   .:.:::|.|| |..
Worm   185 SINESIGTSEIREE----------------DEEEDMDVEDGEHVANQLFGHLLQKSDDKSK-MAS 232

  Fly   448 EKEKSHSPVERVKTPKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRER 512
            ....:..|.            ||.|:...|                 ...||..       |...
Worm   233 LFNHAFPPF------------AAFPNMPPP-----------------FLMRQPF-------DPRA 261

  Fly   513 DLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKL 577
            |:.            :|.|...             |..||.|:||..:.|..|::.||.:.....
Worm   262 DVF------------AAGRHDN-------------DDDWEALMEISTSDEAEKIRALVGDKAVPT 301

  Fly   578 TDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIK-------- 634
            |||||||.|::|:||:|:||||.|||||||||:||||.|||.||||||.||.:|:.|
Worm   302 TDPNQCILCRRVLSCKSALQMHYRTHTGERPFKCKICQRAFTTKGNLKTHMGVHRSKHSFRGLPI 366

  Fly   635 --PPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLG 697
              ||     :....|| ..:.|...|.|.||.....:....|..|....:::..|..|
Worm   367 SLPP-----QLAAMHQ-HQHQIAPPQRIHIHNPPTSAASAAAAVAQIQASQQCPICQQ------- 418

  Fly   698 TSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERER 762
                                        .|:            :|.....|..|
Worm   419 ----------------------------RFL------------NAGELAVHITE----------- 432

  Fly   763 RIPNDCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLG 827
                       |.|                .|:.|                          |.:
Worm   433 -----------HRN----------------SLTQP--------------------------PRV- 443

  Fly   828 MPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAA------ 886
            ||.|....:..               ||.:||                  |...|||.|
Worm   444 MPTPTTTRVQT---------------FPFVPF------------------FTTPPSLNATDMSTQ 475

  Fly   887 ------LESHLQSEHAKEPATGHAQRPQCSDAGSPYGAKLTLN--PNLFAKKPPSSSSSSSG--- 940
                  |.:.|:::.:....|...:.            |:|.:  |.:.:..|.:||.|||.
Worm   476 FNLANILSAQLKNDSSPNTDTSSVEE------------KITRDDPPKMASLSPSNSSDSSSSVRQ 528

  Fly   941 ---------EKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGD 996
                     |||.:...||...:....||   :|..|
Worm   529 DILESSEFEEKLKKLEEPPILEQQVSTTP---NPKNE---------------------------- 562

  Fly   997 AEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRT 1061
                             :||...|.:.:...|......||.:||.|.||.::|||||||||||||
Worm   563 -----------------NPLLAMQKMWAETEPPPPRQMPVLSKHQCGVCFKHFSSSSALQIHMRT 610

  Fly  1062 HTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMRPGPNSGQGHPGSSAEQ 1126
            |||||||:|::|.:||||:||||||||||.|....||||||:.              ...||..:
Worm   611 HTGDKPFKCDMCGRAFTTRGNLKVHMGTHSWQQSPSRRGRRIF--------------DVASSVTE 661

  Fly  1127 EFMQRRPELFFPYLPPFFNGLPPKPGELSPGAFPNIPPPPFANGGKYPYPPGLLGF--------- 1182
                 :|.|..|.||.  :|        :|||      .|.|..|    |.||.|.
Worm   662 -----KPMLQSPILPT--SG--------APGA------SPLAMLG----PNGLSGLEMMMMLWRT 701

  Fly  1183 -----------PGFLAQHPYILERRSSSKSPTPEPAQSPA 1211
                       |..|.||  :.|..::..|..|.|..|.|
Worm   702 VCSVCQKVCQSPNELEQH--LKEHLNNGSSAAPTPLASAA 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	8/24 (33%)
		C2H2 Zn finger	323..343	CDD:275368	8/22 (36%)
		zf-H2C2_2	335..360	CDD:290200	11/26 (42%)
		C2H2 Zn finger	351..371	CDD:275368	5/25 (20%)
		C2H2 Zn finger	583..603	CDD:275368	12/19 (63%)
		zf-H2C2_2	595..620	CDD:290200	20/24 (83%)
		C2H2 Zn finger	611..631	CDD:275368	15/19 (79%)
		C2H2 Zn finger	643..663	CDD:275368	5/19 (26%)
		lambda-1	1013..>1061	CDD:212564	22/47 (47%)
		zf-C2H2	1040..1062	CDD:278523	16/21 (76%)
		C2H2 Zn finger	1042..1062	CDD:275368	15/19 (79%)
		zf-H2C2_2	1054..1079	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1070..1090	CDD:275368	14/19 (74%)
sem-4	NP_491997.1	C2H2 Zn finger	307..327	CDD:275368	12/19 (63%)
		zf-H2C2_2	319..344	CDD:290200	20/24 (83%)
		C2H2 Zn finger	335..355	CDD:275368	15/19 (79%)
		lambda-1	553..>610	CDD:212564	26/104 (25%)
		zf-C2H2	589..611	CDD:278523	16/21 (76%)
		C2H2 Zn finger	591..611	CDD:275368	15/19 (79%)
		zf-H2C2_2	603..628	CDD:290200	19/24 (79%)
		C2H2 Zn finger	619..639	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm14690
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23233
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930