DRSC/TRiP Functional Genomics Resources

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Protein Alignment salr and ZNF433

DIOPT Version :9

Sequence 1:NP_001245983.1 Gene:salr / 34568 FlyBaseID:FBgn0000287 Length:1267 Species:Drosophila melanogaster
Sequence 2:XP_011526027.1 Gene:ZNF433 / 163059 HGNCID:20811 Length:684 Species:Homo sapiens


Alignment Length:918 Identity:185/918 - (20%)
Similarity:290/918 - (31%) Gaps:353/918 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 ENSKTDKRGTEDRKAE-PEGYQSMMCDISSSLASSIITNHDPPPAPNEPNCLEMLQRRTEEV--- 287
            ||.:.:.|...:|..| .||:|.          ..|:|.     .|:     :||::.|..|   
Human    71 ENLRRNLRIVGERLFESKEGHQH----------GEILTQ-----VPD-----DMLKKTTTGVKSC 115

  Fly   288 -------LDSASQSL---------HAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSAL 336
                   :.||..||         |.|.   ||.||..|         .::||||.|.|...|::
Human   116 ESSVYGEVGSAHSSLNRHIRDDTGHKAY---EYQEYGQK---------PYKCKYCKKPFNCLSSV 168

  Fly   337 QIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQY 401
            |.|.|:|:|.:.:||..||..|.:..||    |||               .:.|.|.|       
Human   169 QTHERAHSGRKLYVCEECGKTFISHSNL----QRH---------------RIMHRGDG------- 207

  Fly   402 PIRLPFAPPVAP------VGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERVK 460
            |.:..|......      :.:..|..  |:|.:.:|               ..|..|||...|:.
Human   208 PYKCKFCGKALMFLSLYLIHKRTHTG--EKPYQCKQ---------------CGKAFSHSSSLRIH 255

  Fly   461 TPKEVKTDAALPSSEKPEK--EISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKL 523
            ....        :.|||.|  |..|...:|:..:.   .::|.....|.|            .|.
Human   256 ERTH--------TGEKPYKCNECGKAFHSSTCLHA---HKRTHTGEKPYE------------CKQ 297

  Fly   524 VRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIE-----NKLTDPNQC 583
            ..::.:|..|    :.:.:.....:|.:|       ..|..|..:...::.     :....|.:|
Human   298 CGKAFSSSHS----FQIHERTHTGEKPYE-------CKECGKAFKCPSSVRRHERTHSRKKPYEC 351

  Fly   584 IFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQ 648
            ..|.||:|..:|.|.|:..||||...:|||||:||.:..:|:.|...|..:.|    :||..|.:
Human   352 KHCGKVLSYLTSFQNHLGMHTGEISHKCKICGKAFYSPSSLQTHEKTHTGEKP----YKCNQCGK 412

  Fly   649 KFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSG 713
            .|::....:.|.|.||           ...|.|.::.|       |:..::..|  .|....|:|
Human   413 AFNSSSSFRYHERTHT-----------GEKPYECKQCG-------KAFRSASLL--QTHGRTHTG 457

  Fly   714 QRSESSQ--GGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCS------- 769
            ::..:.:  |..|..|.....                   .||...:|:    |.:|.       
Human   458 EKPYACKECGKPFSNFSFFQI-------------------HERMHREEK----PYECKGYGKTFS 499

  Fly   770 -------DERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLG 827
                   .||:|     |||::..           ....||.|                      
Human   500 LPSLFHRHERTH-----TGGKTYE-----------CKQCGRSF---------------------- 526

  Fly   828 MPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQ 892
                     ..::....|...|...|                 |..|..|.|...|.:.|:.|.:
Human   527 ---------NCSSSFRYHGRTHTGEK-----------------PYECKQCGKAFRSASQLQIHGR 565

  Fly   893 SEHAKEPATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPP 957
            :...::|.       :|...|..:|:...|..:         ..:.:|||       |:      
Human   566 THTGEKPY-------ECKQCGKAFGSASHLQMH---------GRTHTGEK-------PY------ 601

  Fly   958 ATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQAL 1022
                            |....|:..|..:                ::|:|..             
Human   602 ----------------ECKQCGKSFGCAS----------------RLQMHGR------------- 621

  Fly  1023 MSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHM 1087
                  |.:.:.|    :.|..|.:.|...|.|:.|.|||||:||::||.|.|.|.....|:||.
Human   622 ------THTGEKP----YKCKQCGKAFGCPSNLRRHGRTHTGEKPYKCNQCGKVFRCSSQLQVHG 676

  Fly  1088 GTHMWTNP 1095
            ..|....|
Human   677 RAHCIDTP 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
salrNP_001245983.1 zf-C2H2 321..343 CDD:278523 10/21 (48%)
C2H2 Zn finger 323..343 CDD:275368 10/19 (53%)
zf-H2C2_2 335..360 CDD:290200 10/24 (42%)
C2H2 Zn finger 351..371 CDD:275368 7/19 (37%)
C2H2 Zn finger 583..603 CDD:275368 8/19 (42%)
zf-H2C2_2 595..620 CDD:290200 14/24 (58%)
C2H2 Zn finger 611..631 CDD:275368 9/19 (47%)
C2H2 Zn finger 643..663 CDD:275368 5/19 (26%)
lambda-1 1013..>1061 CDD:212564 8/47 (17%)
zf-C2H2 1040..1062 CDD:278523 7/21 (33%)
C2H2 Zn finger 1042..1062 CDD:275368 7/19 (37%)
zf-H2C2_2 1054..1079 CDD:290200 14/24 (58%)
C2H2 Zn finger 1070..1090 CDD:275368 8/19 (42%)
ZNF433XP_011526027.1 KRAB 18..>60 CDD:214630
KRAB 18..57 CDD:279668
C2H2 Zn finger 145..175 CDD:275368 14/38 (37%)
C2H2 Zn finger 183..203 CDD:275368 9/38 (24%)
COG5048 208..614 CDD:227381 107/612 (17%)
C2H2 Zn finger 211..231 CDD:275368 1/19 (5%)
zf-H2C2_2 227..248 CDD:290200 5/37 (14%)
C2H2 Zn finger 239..259 CDD:275368 6/34 (18%)
zf-H2C2_2 251..276 CDD:290200 7/32 (22%)
C2H2 Zn finger 267..287 CDD:275368 3/22 (14%)
zf-H2C2_2 283..304 CDD:290200 4/32 (13%)
C2H2 Zn finger 295..315 CDD:275368 3/23 (13%)
zf-H2C2_2 307..332 CDD:290200 5/35 (14%)
C2H2 Zn finger 323..343 CDD:275368 2/19 (11%)
C2H2 Zn finger 351..371 CDD:275368 8/19 (42%)
C2H2 Zn finger 379..399 CDD:275368 9/19 (47%)
zf-H2C2_2 391..416 CDD:290200 8/28 (29%)
C2H2 Zn finger 407..427 CDD:275368 5/19 (26%)
zf-H2C2_2 419..444 CDD:290200 8/42 (19%)
C2H2 Zn finger 435..455 CDD:275368 4/28 (14%)
C2H2 Zn finger 463..483 CDD:275368 5/38 (13%)
C2H2 Zn finger 491..511 CDD:275368 3/19 (16%)
C2H2 Zn finger 519..539 CDD:275368 4/50 (8%)
C2H2 Zn finger 547..567 CDD:275368 6/19 (32%)
C2H2 Zn finger 575..595 CDD:275368 4/28 (14%)
C2H2 Zn finger 603..623 CDD:275368 4/54 (7%)
C2H2 Zn finger 631..651 CDD:275368 7/19 (37%)
zf-H2C2_2 643..668 CDD:290200 14/24 (58%)
C2H2 Zn finger 659..679 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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