DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and ZNF234

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001138296.1	Gene:	ZNF234 / 10780	HGNCID:	13027	Length:	700	Species:	Homo sapiens

Alignment Length:	992	Identity:	194/992 - (19%)
Similarity:	319/992 - (32%)	Gaps:	365/992 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 VQRQHLMQLQLIQHLQSQLKRAEAAALGRH--SHS----DEEEEEPEPEPEPKKQPTNGLKEELE 210
            ||| :|.|..::::.::.|      ::|.|  .|.    ::|::....:...:::..:..|.:.|
Human    28 VQR-NLYQDVMLENFRNLL------SVGHHPFKHDVFLLEKEKKLDIMKTATQRKGKSADKIQSE 85

  Fly   211 LEQGPESEQDQE---SRREENSKTDKRGTEDRKAEPEGYQSMMC--------DISSSLASSIITN 264
            :|..||:.:.:|   .:..:...:|....||         ||:.        |:|..:.:.:.|.
Human    86 VETVPEAGRHEELYWGQIWKQIASDLIKYED---------SMISISRFPRQGDLSCQVRAGLYTT 141

  Fly   265 HDPPPAPNEPNCLEMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKI 329
            |   .......|.|..:..|:.......|.||:.:.                   .|.|..|||.
Human   142 H---TGQKFYQCDEYKKSFTDVFNFDLHQQLHSGEK-------------------SHTCDECGKS 184

  Fly   330 FGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQG 394
            |...|||.||.|.|.||:.:.|:|||.:|:...:|:.|.:.||...|...:         ..|:|
Human   185 FCYISALHIHQRVHMGEKCYKCDVCGKEFSQSSHLQTHQRVHTVEKPFKCV---------ECGKG 240

  Fly   395 QVQGEQYPIRLPFAPPVAPVGQEQ------HQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSH 453
            ..:.....:.........|...|:      |.:.::|.:.|...         .||.     |..
Human   241 FSRRSTLTVHCKLHSGEKPYNCEECGRAFIHASHLQEHQRIHTG---------EKPF-----KCD 291

  Fly   454 SPVERVKTPKEVKTDAALPSSEKPEK--EISKPVVTSSRRNGSVRKRQTSAVSPPQ-EDRERDLV 515
            :..:..:....:.....:.:.|||.|  :..|....||  |..:.:|..:...|.: |:..:..:
Human   292 TCGKNFRRRSALNNHCMVHTGEKPYKCEDCGKCFTCSS--NLRIHQRVHTGEKPYKCEECGKCFI 354

  Fly   516 EHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKT-------SETSKLQQLVDNI 573
                              ||:::...:.....:|.:     :.|.       |.:.:..|.|...
Human   355 ------------------QPSQFQAHRRIHTGEKPY-----VCKVCGKGFIYSSSFQAHQGVHTG 396

  Fly   574 ENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMR 638
            |.    |.:|..|.|....:...|:|:..||||:|::|::||:||.....||.|:..|.::.|
Human   397 EK----PYKCNECGKSFRMKIHYQVHLVVHTGEKPYKCEVCGKAFRQSSYLKIHLKAHSVQKP-- 455

  Fly   639 SQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLD 703
              |||..|.|.|:....||.|..|||           ...|.:.|..|         .|.|...|
Human   456 --FKCEECGQGFNQSSRLQIHQLIHT-----------GEKPYKCEECG---------KGFSRRAD 498

  Fly   704 FSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDC 768
            .......|:|::                               |:..|               :|
Human   499 LKIHCRIHTGEK-------------------------------PYNCE---------------EC 517

  Fly   769 SDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPN 833
            ....|.::..||..|..|||.|..
Human   518 GKVFSQASHLLTHQRVHSGEKPFK----------------------------------------- 541

  Fly   834 LLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKE 898
                                                    |..|.|.....|.|::| |..|
Human   542 ----------------------------------------CEECGKSFSRSAHLQAH-QKVH--- 562

  Fly   899 PATGHAQRP-QCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIK 962
              ||  ::| :|.:.|.  |.|.:||.::..:       ..:|||
Human   563 --TG--EKPYKCGECGK--GFKWSLNLDMHQR-------VHTGEK-------------------- 594

  Fly   963 EDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGP 1027
                                        |...|:..:         |...||.|...|::.:...
Human   595 ----------------------------PYTCGECGK---------HFSQASSLQLHQSVHTGEK 622

  Fly  1028 PTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNL----KVH-M 1087
            |           :.|.||.:.||.||.||.|.|.|||:||::|.:|.|.|:.:.||    |:| .
Human   623 P-----------YKCDVCGKVFSRSSQLQYHRRVHTGEKPYKCEICGKRFSWRSNLVSHHKIHAA 676

  Fly  1088 GTHMWTNPTSRRGRRMS 1104
            ||....:..|:..|.:|
Human   677 GTFYENDENSKNIRELS 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	12/21 (57%)
		C2H2 Zn finger	323..343	CDD:275368	11/19 (58%)
		zf-H2C2_2	335..360	CDD:290200	13/24 (54%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	595..620	CDD:290200	12/24 (50%)
		C2H2 Zn finger	611..631	CDD:275368	8/19 (42%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	15/47 (32%)
		zf-C2H2	1040..1062	CDD:278523	11/21 (52%)
		C2H2 Zn finger	1042..1062	CDD:275368	11/19 (58%)
		zf-H2C2_2	1054..1079	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1070..1090	CDD:275368	9/24 (38%)
ZNF234	NP_001138296.1	KRAB	8..65	CDD:214630	10/43 (23%)
		KRAB	8..47	CDD:279668	6/25 (24%)
		KRNB	91..147		11/67 (16%)
		COG5048	<101..306	CDD:227381	50/258 (19%)
		C2H2 Zn finger	150..170	CDD:275368	4/19 (21%)
		C2H2 Zn finger	178..198	CDD:275368	11/19 (58%)
		zf-C2H2	204..226	CDD:278523	7/21 (33%)
		C2H2 Zn finger	206..226	CDD:275368	7/19 (37%)
		zf-H2C2_2	218..243	CDD:290200	7/33 (21%)
		C2H2 Zn finger	234..254	CDD:275368	2/28 (7%)
		COG5048	258..672	CDD:227381	129/692 (19%)
		C2H2 Zn finger	262..282	CDD:275368	3/19 (16%)
		zf-H2C2_2	274..299	CDD:290200	5/38 (13%)
		C2H2 Zn finger	290..310	CDD:275368	0/19 (0%)
		C2H2 Zn finger	318..338	CDD:275368	5/21 (24%)
		zf-H2C2_2	330..355	CDD:290200	4/42 (10%)
		C2H2 Zn finger	346..366	CDD:275368	3/37 (8%)
		zf-H2C2_2	359..383	CDD:290200	2/28 (7%)
		C2H2 Zn finger	374..394	CDD:275368	3/19 (16%)
		C2H2 Zn finger	402..422	CDD:275368	5/19 (26%)
		zf-H2C2_2	414..439	CDD:290200	12/24 (50%)
		C2H2 Zn finger	430..450	CDD:275368	8/19 (42%)
		C2H2 Zn finger	458..478	CDD:275368	7/19 (37%)
		zf-H2C2_2	471..495	CDD:290200	10/43 (23%)
		C2H2 Zn finger	486..506	CDD:275368	5/28 (18%)
		zf-H2C2_2	498..523	CDD:290200	6/70 (9%)
		C2H2 Zn finger	514..534	CDD:275368	6/34 (18%)
		zf-H2C2_2	526..551	CDD:290200	10/105 (10%)
		C2H2 Zn finger	542..562	CDD:275368	7/20 (35%)
		zf-H2C2_2	554..578	CDD:290200	10/33 (30%)
		C2H2 Zn finger	570..590	CDD:275368	6/28 (21%)
		zf-H2C2_2	582..607	CDD:290200	7/88 (8%)
		C2H2 Zn finger	598..618	CDD:275368	6/28 (21%)
		zf-H2C2_2	610..635	CDD:290200	7/35 (20%)
		C2H2 Zn finger	626..646	CDD:275368	11/19 (58%)
		zf-H2C2_2	639..662	CDD:290200	12/22 (55%)
		C2H2 Zn finger	654..674	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000