DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and bcl11bb

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_002667906.3	Gene:	bcl11bb / 100330974	ZFINID:	ZDB-GENE-110201-2	Length:	794	Species:	Danio rerio

Alignment Length:	791	Identity:	171/791 - (21%)
Similarity:	260/791 - (32%)	Gaps:	244/791 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 FVCNVCGSKFTTKGNLKVHYQR-------------HTQIFPPMLLPPGVAPNVGHSGQGQVQGEQ 400
            ::|..|...||:...|..|.|.             ...:.|.|.|||.:..:.
Zfish   151 YICTTCKQPFTSAWFLLQHAQNTHGIRIYLDTHPTSCSLTPRMALPPPLGADA------------ 203

  Fly   401 YPIRLPFAPPVAPVGQEQHQNQ--------VEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVE 457
                ||.:|..:.:|...:..|        :.||.....|..:|.    :.|.|......| |:|
Zfish   204 ----LPRSPLASFLGDGSNPFQLLRMGAPLLREPPHGYIETRLPS----TPPFVSPPPPRH-PLE 259

  Fly   458 RVKTPKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQ------TSAVSPPQEDRERDLVE 516
            |: .|:|:...:..||:.:....::...:.......|.|.|:      ....:||........:.
Zfish   260 RL-GPEEMGLLSQHPSAFERVMRMTPMGIHEPSMGFSQRLRELAGNNNNGGPTPPLSPNRVPPMH 323

  Fly   517 HLHIAKLVRRSSAS-----RESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENK 576
            .|....|.:..|.:     ..|||....                  .:.:.:|.|        |:
Zfish   324 RLLSPTLFQHGSKALPFLPTPSQPPSIP------------------SRGNSSSPL--------NQ 362

  Fly   577 LTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQF 641
            :.....|.||.|....:|:|.:|.|:||||||::|.:|..|.:....||.||..|
Zfish   363 VGKAKSCEFCGKTFKFQSNLIVHRRSHTGERPYKCHLCDHACSQASKLKRHMKTH---------- 417

  Fly   642 KCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFST 706
                .|:..|.|...:|           |||.    :.||    |::....|   ||.:.:|...
Zfish   418 ----MHKSGSMGSSPEQ-----------GGQD----SAGE----GLKSCEDN---GTREGIDNEE 456

  Fly   707 TISDHSGQRSESSQ-----GGDFDEFMTMDS-TDDSRDNSSAATATPHPLERERDREK-----ER 760
            ...|...:..|..:     |...|..::||| ...:|:|....|....||..:|..|.     :.
Zfish   457 EEDDEEEEEEEEEEEEQQNGSRPDSNLSMDSELSRNRENGPRTTPEDKPLATDRVTESQYNNLDN 521

  Fly   761 ERRIPNDCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPM 825
            ..|:|              .|.|...|    ||..|.:....| ....:.||...|...:.....
Zfish   522 HLRLP--------------PGSRPCEG----MDRDSQAREIDR-DRQPMVNGRGCGPEDSISAMF 567

  Fly   826 LGMPMP---PNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAAL 887
            ...|||   .:|...:|.|.::    ....:.|.:|        :..|.||.:   ::|...||
Zfish   568 HRKPMPISSSSLSGSSAKRIKV----EKDVELPQVP--------VISPENVYS---QLLAGYAA- 616

  Fly   888 ESHLQSEH-AKEPATGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPF 951
                 |.| .:||..|.....|     ||:|.             ||..|||....|..|:
Zfish   617 -----SRHFIREPFLGFNDSRQ-----SPFGT-------------PSEHSSSETGSLRFST---- 654

  Fly   952 PAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPL 1016
                ||..           ::|.|..:|.     :.|:.|               |.|
Zfish   655 ----PPGE-----------ILEGGGMSGR-----SDSSTP---------------HLH------- 677

  Fly  1017 DFQQALMSAGP--PTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTT 1079
                 |...||  |.||.:.  .....|..|.:.|.:.|.|.:|.|:|||::|::|::|..|...
Zfish   678 -----LRGPGPGRPPSSKES--RRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCDLCSYACAQ 735

  Fly  1080 KGNLKVHMGTH 1090
            ...|..||.||
Zfish   736 SSKLTRHMKTH 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523
		C2H2 Zn finger	323..343	CDD:275368
		zf-H2C2_2	335..360	CDD:290200	3/10 (30%)
		C2H2 Zn finger	351..371	CDD:275368	7/32 (22%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	595..620	CDD:290200	12/24 (50%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	643..663	CDD:275368	4/19 (21%)
		lambda-1	1013..>1061	CDD:212564	12/49 (24%)
		zf-C2H2	1040..1062	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	10/24 (42%)
		C2H2 Zn finger	1070..1090	CDD:275368	6/19 (32%)
bcl11bb	XP_002667906.3	zf-C2H2	368..389	CDD:278523	8/20 (40%)
		C2H2 Zn finger	369..389	CDD:275368	8/19 (42%)
		zf-H2C2_2	381..406	CDD:290200	12/24 (50%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-C2H2	697..718	CDD:278523	7/20 (35%)
		C2H2 Zn finger	698..718	CDD:275368	7/19 (37%)
		zf-H2C2_2	710..735	CDD:290200	10/24 (42%)
		C2H2 Zn finger	726..746	CDD:275368	6/19 (32%)
		C2H2 Zn finger	756..774	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930