DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and ZNF717

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_011531546.1	Gene:	ZNF717 / 100131827	HGNCID:	29448	Length:	948	Species:	Homo sapiens

Alignment Length:	1132	Identity:	231/1132 - (20%)
Similarity:	361/1132 - (31%)	Gaps:	395/1132 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 VPESDTERETAEERGEEQEPENSNEALDLSLISSGGRESL-PGSGHVSLEALQHTKVAVAQFAAT 131
            :..|:|..:...|.|:... .|||..|:| :|::|....: ||..:.....|...|
Human   151 ITNSNTSTQERVELGKTFN-LNSNHVLNL-IINNGNSSGMKPGQFNDCQNMLFPIK--------- 204

  Fly   132 AMAGNHQSADLAMVQSTIFNVQRQHLMQLQLIQH--LQSQLKRAEAAALGRHSHSDE-------- 186
              .|..||.:...|...   .:|.|.....|.||  :|:.|:..:....|:..:::.
Human   205 --PGETQSGEKPHVCDI---TRRSHRHHEHLTQHHKIQTLLQTFQCNEQGKTFNTEAMFFIHKRV 264

  Fly   187 -------EEEEPEPEPEPKK----------QPTNGLKEELELEQ----GPESEQDQESRREENSK 230
                   :..|.|.......          |||...|.:....|    |.:..:..|..:...||
Human   265 HIVQTFGKYNEYEKACNNSAVIVQVITQVGQPTCCRKSDFTKHQQTHTGEKPYECVECEKPSISK 329

  Fly   231 TD-----KRGTEDRKAEPEGYQSMMCDISSSLASSIITNH-----DPPPAPNEPNCLEMLQRRTE 285
            :|     |..||::.     |....|:...|..||:|.:.     :.|...||  |.:..:|:
Human   330 SDLMLQCKMPTEEKP-----YACNWCEKLFSYKSSLIIHQRIHTGEKPYGCNE--CGKTFRRK-- 385

  Fly   286 EVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFV 350
                 :..:||      |.:....|         .::|..|||.|...|.|.:|.|:|:||:|:.
Human   386 -----SFLTLH------ERTHTGDK---------PYKCIECGKTFHCKSLLTLHHRTHSGEKPYQ 430

  Fly   351 CNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLPFAPPVAPVG 415
            |:.||..|:.|..|.:|::.||                         ||:     |:|
Human   431 CSECGKTFSQKSYLTIHHRTHT-------------------------GEK-----PYA------- 458

  Fly   416 QEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPSSEKPEK- 479
                .:..||....:..:.|.|             ::|                   :.|||.:
Human   459 ----CDHCEEAFSHKSRLTVHQ-------------RTH-------------------TGEKPYEC 487

  Fly   480 -EISKPVVTSSRRNGSVRKRQ-TSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQ 542
             |..||.:..|    ::|..| |.....|.|..|        ..|...|.|.        .::.|
Human   488 NECGKPFINKS----NLRLHQRTHTGEKPYECNE--------CGKTFHRKSF--------LTIHQ 532

  Fly   543 MERIIDKSWEDLIEIDKTSETSKLQQL--VDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTG 605
            .....:|.:    |.::..:|.:.:..  |....:....|..|..|.|..|.:|.|.:|.|||||
Human   533 WTHTGEKPY----ECNECGKTFRCKSFLTVHQRTHAGEKPYACNECGKTYSHKSYLTVHHRTHTG 593

  Fly   606 ERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSG 670
            |:|:.|..||::|..|..|..|...|..|.|    ::|..|.:.|.|.:.|..|.|.||
Human   594 EKPYECNECGKSFHCKSFLTIHQRTHAGKKP----YECNECEKTFINKLNLGIHKRTHT------ 648

  Fly   671 GQGAPAANPGEAERLG-IEDQNSNKSLGTSDTLDFSTTISDHSGQR----SESSQGGDFDEFMTM 730
                 ...|.|....| ...|.||          .||....|:|::    :|..:......|:|:
Human   649 -----GERPYECNECGKTFRQKSN----------LSTHQGTHTGEKPYVCNECGKTFHRKSFLTI 698

  Fly   731 DSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSNPDLTGGRSESGEMPAMDLS 795
            .....:..|............|.......||                 ||.|:|   .|..|::.
Human   699 HQRTHTGKNRMDVMNVEKLFVRNHTLLYIRE-----------------LTPGKS---PMNVMNVE 743

  Fly   796 SP-----SSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFP 855
            :|     ...|.::|..|
Human   744 NPFIRRQIFRSIKVFTRG----------------------------------------------- 761

  Fly   856 LLPFGPLGFMGLHPPPNVCNL---CFKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYG 917
                        ..|.||.|:   |.|     :.|..|.::...::|.       :|::.|..:.
Human   762 ------------RNPMNVANVEKPCQK-----SVLTVHHRTHTGEKPY-------ECNECGKTFC 802

  Fly   918 AKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGS 982
            .|..|:         :...:.||||       |:..:....|..    |:..|.:.:....||
Human   803 HKSNLS---------THQGTHSGEK-------PYECDECRKTFY----DKTVLTIHQRTHTGE-- 845

  Fly   983 GTGATSNYPQEAGDAEQSL-MKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCR 1046
                   .|.|..:..::. .|.:|..|.                 .|.:.:.|..    |:.||
Human   846 -------KPFECKECRKTFSQKSKLFVHH-----------------RTHTGEKPFR----CNECR 882

  Fly  1047 RNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMRP 1111
            :.||..|.|.||.|||||:||::|..|.|.|..|.:|..|..||:
Human   883 KTFSQKSGLSIHQRTHTGEKPYECKECGKTFCQKSHLSRHQQTHI-------------------- 927

  Fly  1112 GPNSGQGHPGSSAEQEFMQRRPELFFP 1138
                  |.....||..::..:...|||
Human   928 ------GEKSDVAEAGYVFPQNHSFFP 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	9/21 (43%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	11/24 (46%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	595..620	CDD:290200	13/24 (54%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	11/47 (23%)
		zf-C2H2	1040..1062	CDD:278523	10/21 (48%)
		C2H2 Zn finger	1042..1062	CDD:275368	10/19 (53%)
		zf-H2C2_2	1054..1079	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/19 (37%)
ZNF717	XP_011531546.1	KRAB	56..116	CDD:214630
		KRAB	56..95	CDD:279668
		C2H2 Zn finger	217..237	CDD:275368	5/22 (23%)
		COG5048	343..723	CDD:227381	116/530 (22%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		C2H2 Zn finger	375..395	CDD:275368	7/34 (21%)
		zf-H2C2_2	388..412	CDD:290200	9/38 (24%)
		C2H2 Zn finger	403..423	CDD:275368	9/19 (47%)
		zf-H2C2_2	416..440	CDD:290200	11/23 (48%)
		zf-C2H2	429..451	CDD:278523	7/21 (33%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		zf-H2C2_2	443..468	CDD:290200	10/65 (15%)
		C2H2 Zn finger	459..479	CDD:275368	4/32 (13%)
		zf-H2C2_2	472..494	CDD:290200	8/53 (15%)
		C2H2 Zn finger	487..507	CDD:275368	6/23 (26%)
		zf-H2C2_2	499..524	CDD:290200	7/32 (22%)
		C2H2 Zn finger	515..535	CDD:275368	5/35 (14%)
		zf-H2C2_2	528..552	CDD:290200	4/27 (15%)
		C2H2 Zn finger	543..563	CDD:275368	2/19 (11%)
		C2H2 Zn finger	571..591	CDD:275368	8/19 (42%)
		zf-H2C2_2	583..608	CDD:290200	13/24 (54%)
		COG5048	595..932	CDD:227381	103/528 (20%)
		C2H2 Zn finger	599..619	CDD:275368	7/19 (37%)
		C2H2 Zn finger	627..647	CDD:275368	7/19 (37%)
		zf-H2C2_2	639..664	CDD:290200	8/35 (23%)
		C2H2 Zn finger	655..675	CDD:275368	6/29 (21%)
		zf-H2C2_2	667..692	CDD:290200	6/34 (18%)
		C2H2 Zn finger	683..703	CDD:275368	3/19 (16%)
		zf-H2C2_2	779..801	CDD:290200	5/28 (18%)
		C2H2 Zn finger	794..814	CDD:275368	4/28 (14%)
		C2H2 Zn finger	822..842	CDD:275368	3/23 (13%)
		zf-H2C2_2	835..859	CDD:290200	5/32 (16%)
		C2H2 Zn finger	850..870	CDD:275368	3/36 (8%)
		zf-H2C2_2	863..887	CDD:290200	8/44 (18%)
		C2H2 Zn finger	878..898	CDD:275368	10/19 (53%)
		zf-H2C2_2	891..913	CDD:290200	13/21 (62%)
		zf-C2H2	904..926	CDD:278523	7/21 (33%)
		C2H2 Zn finger	906..926	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000