DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and sall3

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_002936493.1	Gene:	sall3 / 100038115	XenbaseID:	XB-GENE-491129	Length:	1338	Species:	Xenopus tropicalis

Alignment Length:	1413	Identity:	418/1413 - (29%)
Similarity:	569/1413 - (40%)	Gaps:	412/1413 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ADSNNNGTEPQMEAEAVPE--------SDTERETAEERGEEQEPEN--SNEALD-------LSLI 99
            |.|.:|.||.:...|.:..        .|||||......|..|.:|  |.||.|       :|..
Frog   104 ASSPSNHTESETAEENIQVENNDTCDIKDTEREEEPMEVEITEEKNYPSQEASDSATPLPQISEP 168

  Fly   100 SSGGRESLPGSGHVSLEALQHTKVAVAQF--------------AATAMAGNHQSADLAMVQSTIF 150
            ||....::|.: :|:||.||.||||||||              ||||||       :.|:...:.
Frog   169 SSMTNYNMPNT-NVTLETLQSTKVAVAQFSQNARCVGGTNVATAATAMA-------IPMILEQLM 225

  Fly   151 NVQRQHLMQLQLIQHLQSQLKRAEAAAL----------------------GRHSHSDEEEEEPEP 193
            .:|:|.:.|||||:.::||:.......|                      |..:||..:.....|
Frog   226 ALQQQQIHQLQLIEQIRSQVALMNRQPLRPPLNPTVPAQNVPIPASNQLQGFAAHSTLQLTSVVP 290

  Fly   194 E----PEPKKQPTNGLKEELELEQGPE-----------SEQDQESRRE---------------EN 228
            .    |....||.: .:....:.|.|.           |....||...               .|
Frog   291 PALSGPATSVQPPS-FENPQHMSQPPSGASTPNIPCVVSSAPTESTTSLSTISKATSAAPCSLSN 354

  Fly   229 SKTDKRGTEDRKAEPEGYQSMMCDISSSLASSIITNHDPPPAPNE---PNCLEMLQRRTEEVLDS 290
            |.::....:.....|......:.:.||||.|.::    |..:.|.   ||.|..: ..|...||.
Frog   355 STSNPTHPQSSSTPPSVGHGNILNSSSSLPSPLL----PQSSSNSVIFPNPLVSI-AATANALDP 414

  Fly   291 ASQSL-HAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVC 354
            .|..: |........|.:.:| ..|....|||:|::|.|:|||.||||||||||||||||.||:|
Frog   415 LSALMKHRKGKPPNVSVFETK-TTSDDPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNIC 478

  Fly   355 GSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAP----NVGHSGQGQVQGEQYPIRLPFA------- 408
            |::|:||||||||:|||.:.:|.:.:.|...|    ||..| .|...|...|...|..
Frog   479 GNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEYLDNVPTS-SGIPYGMSLPPEKPVTTWLDSKP 542

  Fly   409 -------------PPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDL---------SKPMVKEKEK 451
                         ||..|.......:....|.....:.|.|.:.:.         |:|.::...:
Frog   543 VLPTITTSIGLQLPPTIPGVNNYSDSPSITPSNRSPQRPSPASSECNSLSPNIHNSEPCIQASSE 607

  Fly   452 SHSPVER-VKTPKEVKTDAALPSS----EKP-EKEISKPVVTSSR--RNGSVRKRQTSAVSPPQE 508
            |..|.:. :.|||:  ...|.|||    |:| ..:|..||.||:.  .:.||.....::|.||..
Frog   608 SPQPAQAGILTPKQ--EPIAQPSSTRVGEQPVNVQIPSPVTTSAPTVTDSSVSTTLPNSVLPPMS 670

  Fly   509 DRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNI 573
            |:.:        ||.                          .:..|:|..:|||||||||||:||
Frog   671 DQFK--------AKF--------------------------PFGGLLESMQTSETSKLQQLVENI 701

  Fly   574 ENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMR 638
            :.|:||||||:.|.:|:||:|:|:||.|||||||||:||||||||.||||||.|..:|:.|||:|
Frog   702 DKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPLR 766

  Fly   639 SQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLD 703
            .|..||:|.:||:|.::||||||:|     .||| .|               |:....|..|.:|
Frog   767 VQHSCPICQKKFTNAVVLQQHIRMH-----MGGQ-IP---------------NTPLPEGFQDAMD 810

  Fly   704 FSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRD---------------NSSAATATPHPLERE 753
             |....|.....:.|:...|||:    :|.||..|               :.|:..:.|..:...
Frog   811 -SELSYDDKNLETMSNYDDDFDD----NSLDDDLDLKDTESDSSKPLIPYSGSSPASPPTVISSI 870

  Fly   754 RDREKERE--------------RRIPNDC--SDERSHSNPDLTGG-RSESGEMPAMDLSSPS--- 798
            ...|.:.:              :.|.|..  ||..|:.:....|. .|:|...|||..||.|
Frog   871 AALENQMKMIDSVMTAQQFIGLKNIENGSGESDHLSNDSSSAVGDLESQSAGSPAMSESSSSMQV 935

  Fly   799 -----SNSGRI--------------------------FATGLANGAAGGGSGNGGLPMLGMPMPP 832
                 |:|..|                          ..|....||....|.|.|.|::....|.
Frog   936 LSPAHSHSESIRSKSPVITSQEEPPLIQLKTEKPDSPITTPENEGALDLTSTNPGRPLIKEEAPY 1000

  Fly   833 NLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAK 897
            :||.::..|          .||               ...|||:|.|.....:|||.|.:| |.|
Frog  1001 SLLFLSRER----------GKF---------------KSTVCNICGKPFACKSALEIHYRS-HTK 1039

  Fly   898 EPATGHAQRP--------QCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAE 954
            |       ||        .||..|:       |..:|...|
Frog  1040 E-------RPFICTVCNRGCSTMGN-------LKQHLLTHK------------------------ 1066

  Fly   955 NPPATPIKEDPDQEQLMVEEGASAGEGSGTGA--TSNYPQEAGDAEQSLMKMQLHAH-------- 1009
                  :||.|.|   :.|...:.|....|.:  ||..|        :::||:::.|
Frog  1067 ------LKELPSQ---LFEPNFTLGPSQTTTSLITSTAP--------AMIKMEVNGHTKPISLGE 1114

  Fly  1010 --------RFPASPLDFQQALMSAGPPTSSLDPP---VNNKHFCHVCRRNFSSSSALQIHMRTHT 1063
                    :.||:|    |..||.| .|..|.||   ...:|.||.|.:.|||:||||||.||||
Frog  1115 GPHLLAGIQVPAAP----QTAMSPG-ITPMLAPPPRRTPKQHNCHSCGKTFSSASALQIHERTHT 1174

  Fly  1064 GDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMRPGPNSGQGHPGSSAEQEF 1128
            |:|||.|.:|.:|||||||||||||||||.|..:|||||:|:|.||  ....|.....|...|:.
Frog  1175 GEKPFGCTICGRAFTTKGNLKVHMGTHMWNNAPARRGRRLSVENPM--ALLGGDALKFSEMFQKD 1237

  Fly  1129 MQRR-----PELFFPYLPPFFNGLPPKPGELSPGAFPNIPPPPFANGGKYPYPPGLLGFPGFLAQ 1188
            :..|     |..:..|.....|||..|..|:|......||..|.:.||. ..||
Frog  1238 LAARAMNVDPGFWNQYAAAITNGLAMKNNEISVIQNGGIPQLPVSLGGS-AIPP----------- 1290

  Fly  1189 HPYILERRSSSKSPTPEPAQSPALR-EEEGSGNI-WHPLSRIKVENNQ 1234
                |...||....|...:..|.:. ::.||.:| ..|.:|...||.:
Frog  1291 ----LGNISSGMDRTRTGSSPPIINLDKVGSESIVSRPFTRFIEENKE 1334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	15/21 (71%)
		C2H2 Zn finger	323..343	CDD:275368	14/19 (74%)
		zf-H2C2_2	335..360	CDD:290200	20/24 (83%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	10/19 (53%)
		zf-H2C2_2	595..620	CDD:290200	20/24 (83%)
		C2H2 Zn finger	611..631	CDD:275368	15/19 (79%)
		C2H2 Zn finger	643..663	CDD:275368	12/19 (63%)
		lambda-1	1013..>1061	CDD:212564	23/50 (46%)
		zf-C2H2	1040..1062	CDD:278523	14/21 (67%)
		C2H2 Zn finger	1042..1062	CDD:275368	13/19 (68%)
		zf-H2C2_2	1054..1079	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1070..1090	CDD:275368	15/19 (79%)
sall3	XP_002936493.1	SAP130_C	287..>371	CDD:374297	12/84 (14%)
		COG5048	438..>744	CDD:227381	127/342 (37%)
		C2H2 Zn finger	447..467	CDD:275368	14/19 (74%)
		zf-H2C2_2	459..484	CDD:372612	20/24 (83%)
		C2H2 Zn finger	475..495	CDD:275368	14/19 (74%)
		C2H2 Zn finger	711..731	CDD:275368	10/19 (53%)
		zf-H2C2_2	723..748	CDD:372612	20/24 (83%)
		C2H2 Zn finger	739..759	CDD:275368	15/19 (79%)
		zf-C2H2	769..791	CDD:333835	12/21 (57%)
		C2H2 Zn finger	771..791	CDD:275368	12/19 (63%)
		C2H2 Zn finger	1017..1037	CDD:275368	9/20 (45%)
		zf-C2HE	<1039..1065	CDD:374466	9/39 (23%)
		C2H2 Zn finger	1045..1065	CDD:275368	5/26 (19%)
		zf-C2H2	1151..1173	CDD:333835	14/21 (67%)
		C2H2 Zn finger	1153..1173	CDD:275368	13/19 (68%)
		zf-H2C2_2	1165..1190	CDD:372612	17/24 (71%)
		C2H2 Zn finger	1181..1201	CDD:275368	15/19 (79%)
		zf-C2H2	1181..1201	CDD:333835	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7550
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47594
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm48132
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.030