DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and sall1

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001090646.1	Gene:	sall1 / 100036618	XenbaseID:	XB-GENE-491393	Length:	1330	Species:	Xenopus tropicalis

Alignment Length:	1377	Identity:	390/1377 - (28%)
Similarity:	546/1377 - (39%)	Gaps:	381/1377 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NNNGTEPQMEAEAVPESDTERE---------------TAEERGEEQEPE---------------- 88
            |.|...|...:..:|.||...|               ...|.||..:|:
Frog   105 NENPPPPAEASSPIPPSDNPDEHMNDTVNNSDQADCSDLSEHGEHGKPDKEESMEVEFSETNNSS 169

  Fly    89 ------------NSNEALDLSLISSGGRESLPG-------------SGHVSLEALQHTKVAVAQF 128
                        ::|..|..|.|::    |||.             :.:|.:|.||.|:||||||
Frog   170 SGSNKVDNGDSSSNNPTLGTSAITT----SLPQVRDLTALGNFSMINSNVIIENLQSTRVAVAQF 230

  Fly   129 ---AATAMAGNHQSADLAMVQSTIFNVQRQHLMQLQLIQ-------------------------- 164
               |.|..|.|::.|..|:::. :..:|:|.:.||.||:
Frog   231 SQEAKTKGAANNKLAVPALMEQ-LLALQQQQIHQLHLIEQIRHQILLLASQSADMPTSASGPQGA 294

  Fly   165 -------------HLQSQLKRAE--AAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQG 214
                         ||..||..|.  |.:|...|.|....::..|...|:..|.|.:.........
Frog   295 LRVSATPLTTLSSHLSQQLAAAAGLAQSLASQSASISGMKQLPPIQLPQSNPVNTVPSISSSSPN 359

  Fly   215 PESEQDQESRREENSKTDKRGTEDRKAEPEGYQSMMCDISSSLASSIITNHDPPPAPNE---PNC 276
            ..:.....:....:......|.......|....|......|||.|.......|.||||.   |..
Frog   360 MNALASTVTSPSSDKVPSSTGGSQVSNPPAPVTSSPAFAISSLLSPASNPLLPQPAPNTTPFPGT 424

  Fly   277 LEMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLR 341
            |..: ..|.|.|:|..:|...:....| ::..|.||     .|||:|::|.|:|||.||||||||
Frog   425 LPSI-GTTAEDLNSLRKSKPPSVTAFE-TKSTSDEA-----FFKHKCRFCAKVFGSDSALQIHLR 482

  Fly   342 SHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAP----NVGHSGQGQVQGEQYP 402
            ||||||||.||:||::|:||||||||:|||.:.:|.:.:.|...|    |:..| .|...|...|
Frog   483 SHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEHLDNIPTS-TGIPYGMSIP 546

  Fly   403 IRLPF-----APPVAP-----VGQEQHQN--------QVEEPEEIRQEIPVPQAEDLSKPMVKEK 449
            ...|.     ..||.|     ||......        :.|||:.|....|.....|..|     .
Frog   547 PEKPVTNWLDTKPVLPTLTTSVGMPLPPTIPTLTSFIKTEEPQPIAISHPTASPPDSVK-----S 606

  Fly   450 EKSHSPVERVKTPKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDL 514
            |.:..|:.:..:....:.:||:|..:|.|::        |:.:..::...|||.||
Frog   607 ETATEPLLKKTSDLPDEAEAAMPILDKEEQQ--------SQNSDCIQNLNTSACSP--------- 654

  Fly   515 VEHLHIAKLVRRSSASRESQPAEYSLAQMERIIDK-SWEDLIEIDKTSETSKLQQLVDNIENKLT 578
                      ...|....|.|........|:...| .:..|:::...||||||||||:||:.|.:
Frog   655 ----------TTGSGISASFPNPLLPLMSEQFKAKFPFGGLLDVAPASETSKLQQLVENIDKKSS 709

  Fly   579 DPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKC 643
            |||:|:.|::|:||:|:|:||.|||||||||:||||||||.||||||.|.|:|:..||:|.|..|
Frog   710 DPNECVICRRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHYSVHRAMPPLRVQHSC 774

  Fly   644 PVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTI 708
            |:|.:||:|.::||||||:|     .||| .|.....|:....:|....:....|.|.||   ..
Frog   775 PICQKKFTNAVVLQQHIRMH-----MGGQ-IPNTPIAESYPDSMESDTGSFDEKTIDDLD---NF 830

  Fly   709 SDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERS 773
            ||.:.:....|...|     |..|.|.|:|:.|   ::|.|.|.......|.:.::.|
Frog   831 SDENMEDCPDSSVPD-----TPKSVDASQDSLS---SSPLPPEVSSITALENQMKLIN------- 880

  Fly   774 HSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAG-GG---SGNGGLPMLGMPMPPNL 834
                        :|....:..|..|:.:|.|...|:.|.::. ||   |.:.|.|
Frog   881 ------------AGLAEQLQASLKSTENGSIEGDGMTNDSSSLGGDMESQSAGSP---------- 923

  Fly   835 LLMAAARE---EMHALGHAHA-----KFP--------LLPFGPLGFMGLHPPP------------ 871
                ||.|   .||||..:::     |.|        .|...|..  ||.|.|
Frog   924 ----AASESTYSMHALSPSNSTNDYLKSPNTDEKIHRALSLDPTS--GLSPTPANGGALDLTSSN 982

  Fly   872 ------------------------NVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRP-QCSD 911
                                    .:|::|.|.....:||:.|.:| |.||       || .|:.
Frog   983 TDKVIKDEHLGVLFPFRERGKYKNTICDICGKTFACQSALDIHYRS-HTKE-------RPFICTV 1039

  Fly   912 AGSPYGAKLTLNPNLFA---KKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVE 973
            ....:..|..|..::..   :..||.....|....|..:.|..|. ||.||.||.:
Frog  1040 CNRGFSTKGNLKQHMLTHQMRDLPSQLFEPSSSMTPTPTVPSTPT-NPLATIIKTE--------- 1094

  Fly   974 EGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPV-- 1036
                 ..|...|::.:..::                  |.:       ::|:|...||...||
Frog  1095 -----FNGFMHGSSQDIKEQ------------------PTN-------IVSSGSLPSSATSPVLL 1129

  Fly  1037 -------NNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTN 1094
                   ..:|:|:.|.::||||||||||.|||||:|||.|.:|.:|||||||||||||||||.:
Frog  1130 PALARRTPKQHYCNACGKSFSSSSALQIHERTHTGEKPFACTICGRAFTTKGNLKVHMGTHMWNS 1194

  Fly  1095 PTSRRGRRMSLELPM-----RP-----------GPNSGQGHPGSSAEQEFMQRRPELFFPYLPPF 1143
            ..:|||||:|::.||     .|           |..:|...|.|...|            |....
Frog  1195 TPARRGRRLSVDGPMAFLGGNPVKFPEMFQKDLGTRAGNADPSSFWNQ------------YAAAL 1247

  Fly  1144 FNGLPPKPGELSPGAFPNIPP--PPFANGGKYPYPPGLLGFPGFLAQHPYILERRSSSKSPTPEP 1206
            .|||..|..|:|......|.|  ....|||..|. .||.|          .||:..:|:...|..
Frog  1248 SNGLAMKTNEISVIQNGGITPMAGSLGNGGSSPI-SGLTG----------SLEKLQNSEPNAPLA 1301

  Fly  1207 AQSPALREEEGS 1218
            ........|.|:
Frog  1302 GLEKLASSENGT 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	15/21 (71%)
		C2H2 Zn finger	323..343	CDD:275368	14/19 (74%)
		zf-H2C2_2	335..360	CDD:290200	20/24 (83%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	10/19 (53%)
		zf-H2C2_2	595..620	CDD:290200	20/24 (83%)
		C2H2 Zn finger	611..631	CDD:275368	16/19 (84%)
		C2H2 Zn finger	643..663	CDD:275368	12/19 (63%)
		lambda-1	1013..>1061	CDD:212564	19/56 (34%)
		zf-C2H2	1040..1062	CDD:278523	14/21 (67%)
		C2H2 Zn finger	1042..1062	CDD:275368	13/19 (68%)
		zf-H2C2_2	1054..1079	CDD:290200	17/24 (71%)
		C2H2 Zn finger	1070..1090	CDD:275368	15/19 (79%)
sall1	NP_001090646.1	PHA03247	<278..683	CDD:223021	116/444 (26%)
		PRK10856	<326..>438	CDD:236776	23/112 (21%)
		SUF4-like	461..543	CDD:411020	46/82 (56%)
		C2H2 Zn finger	464..485	CDD:411020	15/20 (75%)
		C2H2 Zn finger	464..484	CDD:275368	14/19 (74%)
		C2H2 Zn finger	492..512	CDD:411020	14/19 (74%)
		C2H2 Zn finger	492..512	CDD:275368	14/19 (74%)
		C2H2 Zn finger	714..734	CDD:275368	10/19 (53%)
		zf-H2C2_2	726..751	CDD:404364	20/24 (83%)
		C2H2 Zn finger	742..762	CDD:275368	16/19 (84%)
		zf-C2H2	772..794	CDD:395048	12/21 (57%)
		C2H2 Zn finger	774..794	CDD:275368	12/19 (63%)
		C2H2 Zn finger	1009..1029	CDD:275370	7/20 (35%)
		SUF4-like	1012..>1056	CDD:411020	14/51 (27%)
		C2H2 Zn finger	1012..1030	CDD:411020	6/18 (33%)
		zf-C2H2	1035..1057	CDD:395048	3/21 (14%)
		C2H2 Zn finger	1037..1057	CDD:275370	3/19 (16%)
		C2H2 Zn finger	1037..1056	CDD:411020	3/18 (17%)
		SUF4-like	1140..>1187	CDD:411020	33/46 (72%)
		C2H2 Zn finger	1142..1163	CDD:411020	14/20 (70%)
		C2H2 Zn finger	1142..1162	CDD:275368	13/19 (68%)
		C2H2 Zn finger	1170..1190	CDD:275368	15/19 (79%)
		C2H2 Zn finger	1170..1187	CDD:411020	12/16 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7550
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47594
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm48132
Panther	1	1.100	-	-	O	PTHR23233
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.120