DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and znf516

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001153141.1	Gene:	znf516 / 100003866	ZFINID:	ZDB-GENE-060503-194	Length:	1084	Species:	Danio rerio

Alignment Length:	1182	Identity:	233/1182 - (19%)
Similarity:	348/1182 - (29%)	Gaps:	454/1182 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 MQEEYSEYASKEAQSRG-----EIFK---HRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGS 356
            |:.|..|.:.:|..|:|     ::.|   |.|:.||:.|...|:|..|:|.||||:|:.|..|..
Zfish     1 MEVERPEVSEQEPFSKGGHDNPDVKKSRGHTCELCGRSFPFLSSLSQHMRKHTGEKPYKCPHCEH 65

  Fly   357 KFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQ-----VQGEQYPIRLPFAPPVAPVGQ 416
            :...||:||.|.:.|.            ...:..||.|:     .:||:            ..|.
Zfish    66 RSAQKGSLKAHIRSHK------------LDGLSQSGGGEEEDMDEEGEK------------EGGV 106

  Fly   417 EQHQNQVEEPEEIRQEI-PVPQAEDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPSSEKPEKE 480
            .:.|.....|.|..... .|...||.:|...|..:|...|.|..|
Zfish   107 PEDQGSCSSPTESTSACNKVVSGEDATKMRKKSGKKERIPGESGK-------------------- 151

  Fly   481 ISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMER 545
                   .|.:....|||.:.     |.:.|:.:.| ||  |::|......|:|..:...|.:|:
Zfish   152 -------QSVQCSLCRKRLSG-----QAELEKHMQE-LH--KVLRCELCPYETQQEDQLQAHVEK 201

  Fly   546 IIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFR 610
            ......|.:.:...|||.:      |.|..|...|  |..|.:|.:....|:.|::.|.......
Zfish   202 DHPSDEESITKEVSTSEET------DGILGKGEFP--CEQCDQVFTQAWCLKTHMKKHQNSMDHG 258

  Fly   611 CKICGRAFATKGNLKAHMSIH--KIKPPMRSQFK----------------------CPVCHQKFS 651
            |:||||.|.....|::||..|  |:||...|...                      |..|...|.
Zfish   259 CRICGRRFREPWFLRSHMKTHNTKVKPRSNSYLPATVNEVAQDESNLVNEVCLYELCAKCGNFFH 323

  Fly   652 NGIILQQHIRIH--------------------------------------TMDDGSGGQGAPAAN 678
            :...||.|.::|                                      ...:|:.|:..|..:
Zfish   324 DRKSLQLHEQVHKNIEQPLKNKNCNENNFPSVTKTSFLQCLNLKPAGNIENPSEGTIGKRIPELD 388

  Fly   679 P-----------------------GEAERLGIEDQNSNKSLG---------TSDTLDFSTTISDH 711
            |                       |..|||...|...::..|         ...:||.:.:|...
Zfish   389 PVSSYQAWQLATRGKLVEVTERSQGWEERLADADVAYDREKGEYVLLRQDKRKKSLDSTVSIPTK 453

  Fly   712 SGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATA--TPHPLE----RERDREKERERRIPNDCSD 770
            . :|...:||      .|.|...:...||..:|.  :|..|.    |...|...:..:..::|.:
Zfish   454 K-RRGAVTQG------CTPDQHSNGEKNSHVSTGERSPENLSDSEYRPTSRPSRKNSQKTSECLE 511

  Fly   771 --------------------------------ERSHSNPDLTG-------GRSESGEMPAMD--- 793
                                            .::.|:|..||       .:..:|.:...|
Zfish   512 CGKGFRTQQQMVIHMLIRHGGLGETIGGNGLFRKTTSSPSKTGESAGHFRDQRRAGFLGDTDKKP 576

  Fly   794 ---------LSSPSSNSGRI---------------FATGLANGAAGGGSGNGGLP-----MLGMP 829
                     .|.||:.:..|               ..|...:.:....:.:.|.|     :|..|
Zfish   577 YTCEHCDFCTSEPSAIAAHIQTHQSAVRDWGQRSDALTSSLSQSQTHQTNHTGFPRLRNALLQQP 641

  Fly   830 MPP------------------------------------------------------NLLLMAAA 840
            ..|                                                      ::||....
Zfish   642 YWPYTTSTHLERAALSDAALKTEEEKSKGLEESSSTDKAESNLLNLSVDVDNKKEVSSILLNNLV 706

  Fly   841 REE---------------MH-ALGHAHAKFPLLP--------FGPLGFMGLH----PPPNVCNLC 877
            |.:               :| .:.|......|:|        .||...:...    |||   .|.
Zfish   707 RHQCPYCSYATHYPEVLWIHQRIAHKIDSTTLVPKWAPKNGLKGPKTLLDFKRRTGPPP---FLE 768

  Fly   878 FKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYGAKLT--------LNPNLFAKKPPSS 934
            .|..|||..:.|:..|.            |.||..|:.....||        .|.:......|.:
Zfish   769 GKDCPSLPQMRSYRTSP------------PDCSPGGTKKSKPLTSTVESSSSQNKSWHTATAPGA 821

  Fly   935 SSSSSGEKLPE-------------------SSNP---PFPAENP--------------------- 956
            ||.||..|..:                   ||.|   |....||
Zfish   822 SSHSSKHKTSKSRTDELAGSKHKTDIHQNNSSRPMASPQKTGNPKTGSRVVESSLLPQEGLHFML 886

  Fly   957 ----------------PATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQE-----AGDAE-- 998
                            |.||.|.|...:......|.......|....|.:.|.     |..||
Zfish   887 SSKHNLSDQRSSKAHAPQTPSKSDSQAQDTPSVAGYDPWNRLGLSGPSPHSQSKRQSTADGAEGV 951

  Fly   999 ---QSLMK-------MQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSS 1053
               .|.:|       ..|:.|...:|.:..|..|..:|..        ..::.|.|||::|:..|
Zfish   952 TDILSFLKNCNPHDLAALYHHWGYSSAMTEQAGLARSGSQ--------QGEYVCPVCRKSFNQPS 1008

  Fly  1054 ALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGT-HMWTNPTS----RRGRRMSLELPMRPGP 1113
            ..:.|||:|||::||||..|..:.:.|||||.|:.| |......:    ||.|::....||.| |
Zfish  1009 HYRTHMRSHTGERPFQCRYCPYSASQKGNLKTHVQTVHRLAFDNAQYPDRRLRQVPTNEPMDP-P 1072

  Fly  1114 NSGQGHPGSSAE 1125
            .|.|..|....|
Zfish  1073 GSLQAPPHDQLE 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	9/21 (43%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..360	CDD:290200	10/24 (42%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		zf-H2C2_2	595..620	CDD:290200	9/24 (38%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		C2H2 Zn finger	643..663	CDD:275368	6/19 (32%)
		lambda-1	1013..>1061	CDD:212564	12/47 (26%)
		zf-C2H2	1040..1062	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1042..1062	CDD:275368	9/19 (47%)
		zf-H2C2_2	1054..1079	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1070..1090	CDD:275368	9/20 (45%)
znf516	NP_001153141.1	C2H2 Zn finger	32..52	CDD:275368	8/19 (42%)
		zf-H2C2_2	44..69	CDD:290200	10/24 (42%)
		C2H2 Zn finger	60..80	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		C2H2 Zn finger	259..279	CDD:275368	9/19 (47%)
		racA	319..446	CDD:237292	16/126 (13%)
		zf-C2H2	995..1017	CDD:278523	9/21 (43%)
		C2H2 Zn finger	997..1017	CDD:275368	9/19 (47%)
		zf-H2C2_2	1009..1034	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1025..1046	CDD:275368	9/20 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840