DRSC/TRiP Functional Genomics Resources

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Protein Alignment mre11 and MRE11

DIOPT Version :9

Sequence 1:NP_523547.1 Gene:mre11 / 34565 FlyBaseID:FBgn0020270 Length:620 Species:Drosophila melanogaster
Sequence 2:NP_013951.1 Gene:MRE11 / 855264 SGDID:S000004837 Length:692 Species:Saccharomyces cerevisiae


Alignment Length:718 Identity:237/718 - (33%)
Similarity:339/718 - (47%) Gaps:156/718 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 NVIRILVATDNHLGYGEKDAVRGEDSFTAFEEILELAVSEDVDMILLGGDLFHDAVPSQNALHKC 77
            :.||||:.||||:||.|.|.:.|:||:..|.|::.||.:.:|||::..|||||...||:.:|::.
Yeast     7 DTIRILITTDNHVGYNENDPITGDDSWKTFHEVMMLAKNNNVDMVVQSGDLFHVNKPSKKSLYQV 71

  Fly    78 IELLRRYTFGDRPVSLEILSDQGQCFHNAVNQSVNYEDPNLNIAIPVFSIHGNHDDPSGFGRLSS 142
            ::.||....||:|..||:|||..|.||.....:|||||||.||:||||.|.|||||.||...|..
Yeast    72 LKTLRLCCMGDKPCELELLSDPSQVFHYDEFTNVNYEDPNFNISIPVFGISGNHDDASGDSLLCP 136

  Fly   143 LDLLSTSGLVNYFGRWTDLTQVEISPVLMRKGESQLALYGLSHIHDGRLARLIKDFKVKFNCPEN 207
            :|:|..:||:|:||:..:..::::.|:|.:||.::||||||:.:.|.||.|..||..|.|..|  
Yeast   137 MDILHATGLINHFGKVIESDKIKVVPLLFQKGSTKLALYGLAAVRDERLFRTFKDGGVTFEVP-- 199

  Fly   208 VANGEDGNESKEEEDWFHLLVVHQNRADRGPKNYLPEDLLPSFLHLVIWGHEHDCRIEPEENAKK 272
                     :..|.:||:|:.||||........:|||..||.||.:|||||||:|......|..|
Yeast   200 ---------TMREGEWFNLMCVHQNHTGHTNTAFLPEQFLPDFLDMVIWGHEHECIPNLVHNPIK 255

  Fly   273 RFYVSQPGSSVPTSLSEGEAKKKHVGLLEIYKGKF-KLKPLPLETVRPFVYESVVLADHADELGL 336
            .|.|.||||||.|||.|.||:.|:|.:|:|..|:. |:.|:||||:|.|..:|:.|.| ...|..
Yeast   256 NFDVLQPGSSVATSLCEAEAQPKYVFILDIKYGEAPKMTPIPLETIRTFKMKSISLQD-VPHLRP 319

  Fly   337 VEGDASTKVFKFAQERVEAMIERA----------------VAQHTGHPKQPTLPLIRLRLLYTDE 385
            .:.||::   |:..|:||.||..|                ||:   .||    ||||||:.|:..
Yeast   320 HDKDATS---KYLIEQVEEMIRDANEETKQKLADDGEGDMVAE---LPK----PLIRLRVDYSAP 374

  Fly   386 S--------CMFNAIRFGEMLSTRVANVQDVVQFSK---VVKRTKTEAVN----LDKEALRRALE 435
            |        .:.|..||......||||..:||||.|   .|.|:|...:|    .|::..:...|
Yeast   375 SNTQSPIDYQVENPRRFSNRFVGRVANGNNVVQFYKKRSPVTRSKKSGINGTSISDRDVEKLFSE 439

  Fly   436 ADNATRVEELVD--------RYFEEAKSNKPLKLFHSK----ALAEM--------------TYRL 474
            :.....|:.||:        ....|...|:.:|.|..|    ||.|.              ....
Yeast   440 SGGELEVQTLVNDLLNKMQLSLLPEVGLNEAVKKFVDKDEKTALKEFISHEISNEVGILSTNEEF 504

  Fly   475 LEQRDADAAENIVKFYKEKAVDHLMEAMPNDENIDEE--------LERFRALHK----------- 520
            |...||:..:.::|..|..   :.:...|..|| ||.        |:.||:.::           
Yeast   505 LRTDDAEEMKALIKQVKRA---NSVRPTPPKEN-DETNFAFNGNGLDSFRSSNREVRTGSPDITQ 565

  Fly   521 -HGD----LLKMLDTQGLKVKKEEKSM---------------------SVLGSE----------- 548
             |.|    :..:...:..|...:.|.:                     :.||..           
Yeast   566 SHVDNESRITHISQAESSKPTSKPKRVRTATKKKIPAFSDSTVISDAENELGDNNDAQDDVDIDE 630

  Fly   549 ---VNVST-APATGRGAARGRGT-ARTRAGA---TAATRGKGQLDVTVSSTRTSGRQQTLLSSLM 605
               :.||| ......|...||.| .:||..|   ||:.||||:      ::||.  :..:|.||:
Yeast   631 NDIIMVSTDEEDASYGLLNGRKTKTKTRPAASTKTASRRGKGR------ASRTP--KTDILGSLL 687

  Fly   606 GSR 608
            ..:
Yeast   688 AKK 690

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mre11NP_523547.1 mre11 13..413 CDD:273153 179/424 (42%)
MPP_Mre11_N 16..288 CDD:277319 125/271 (46%)
Mre11_DNA_bind 308..469 CDD:282063 61/203 (30%)
MRE11NP_013951.1 mre11 6..413 CDD:273153 180/427 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157343475
Domainoid 1 1.000 233 1.000 Domainoid score I398
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4083
Inparanoid 1 1.050 305 1.000 Inparanoid score I489
Isobase 1 0.950 - 0 Normalized mean entropy S1306
OMA 1 1.010 - - QHG54350
OrthoFinder 1 1.000 - - FOG0005216
OrthoInspector 1 1.000 - - oto100092
orthoMCL 1 0.900 - - OOG6_101854
Panther 1 1.100 - - LDO PTHR10139
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1060
SonicParanoid 1 1.000 - - X3730
TreeFam 00.000 Not matched by this tool.
1413.880

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