Protein Alignment mre11 and Mre11

DIOPT Version :9

• Sequence 1: NP_523547.1
• Gene: mre11 / 34565
• FlyBaseID: FBgn0020270
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_071615.1
• Gene: Mre11 / 64046
• RGDID: 69263
• Length: 706
• Species: Rattus norvegicus
• Alignment Length: 663
• Identity: 269/663 - (40%)
• Similarity: 377/663 - (56%)
• Gaps: 73/663 - (11%)

  Fly    10 DADNVIRILVATDNHLGYGEKDAVRGEDSFTAFEEILELAVSEDVDMILLGGDLFHDAVPSQNAL 74
            |.::..:||||||.|||:.|||||||.|:|..|:|||.||:..:||.|||||||||:..||:..|
  Rat     8 DDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHENKPSRKTL 72

  Fly    75 HKCIELLRRYTFGDRPVSLEILSDQGQCFHNAVNQSVNYEDPNLNIAIPVFSIHGNHDDPSGFGR 139
            |.|:||||:|..|||||..||:|||...|..:....|||.|.||||:|||||||||||||:|...
  Rat    73 HSCLELLRKYCMGDRPVQFEIISDQSVNFGFSKFPWVNYRDGNLNISIPVFSIHGNHDDPTGADA 137

  Fly   140 LSSLDLLSTSGLVNYFGRWTDLTQVEISPVLMRKGESQLALYGLSHIHDGRLARLIKDFKVKFNC 204
            |.:||:||.:|.||:|||...:.:|:|||||::||.::||||||..|.|.||.|:..:.||....
  Rat   138 LCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLR 202

  Fly   205 PENVANGEDGNESKEEEDWFHLLVVHQNRADRGPKNYLPEDLLPSFLHLVIWGHEHDCRIEPEEN 269
            |:           ::|..||:|.|:||||:..|..|::||..|..|:.||||||||:|:|.|..|
  Rat   203 PK-----------EDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIGPTRN 256

  Fly   270 AKKRFYVSQPGSSVPTSLSEGEAKKKHVGLLEIYKGKFKLKPLPLETVRPFVYESVVLADHADEL 334
            .::.||||||||||.|:||.||..|||||||.:...|..::.|||.|||.|..|.||||:|....
  Rat   257 EQQLFYVSQPGSSVVTALSPGETVKKHVGLLRVKGRKMNMQKLPLRTVRQFFMEDVVLANHPSLF 321

  Fly   335 GLVEGDASTKVFKFAQERVEAMIERAVAQHTGHPKQPTLPLIRLRLLYTDESCMFNAIRFGEMLS 399
            .......:..:..|..|::|.|::.|..:..|:|:||..||||||:.|:.....||.:||.:...
  Rat   322 NPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPEKPLIRLRVDYSGGFEPFNVLRFSQKFV 386

  Fly   400 TRVANVQDVVQFSK-VVKRTKT-EAVNLDKEALRRALEADNATRVEELVDRYFEEAKSNKPLKLF 462
            .||||.:||:.|.: ..::.|| |.:|..|..::.|.|. ...|||:||.:||:.|:.|..|.|.
  Rat   387 DRVANPKDVIHFFRHREQKGKTGEEINFGKLIIKPASEG-TTLRVEDLVKQYFQTAEKNVQLSLL 450

  Fly   463 HSKALAEMTYRLLEQRDADAAENIVK--------FYKEKAVDHLMEAMPNDENIDEELERFRA-- 517
            ..:.:.|.....:::.:.||.|.:||        |.||:.:|.|      ::.||||:.|||.
  Rat   451 TERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDAL------EDKIDEEVRRFRESR 509

  Fly   518 ---LHKHGDLLK--MLDTQGLKVKKEEKSMSVLGSEVNV--------------STAPATGRGAAR 563
               .::..|.::  |...:.|:.:.|..:.:....:::.              |..|:.|||..|
  Rat   510 QRNTNEEDDEVREAMSRARALRSQSENAASAFSADDLSFDITEQTADDSDDSQSAVPSRGRGRGR 574

  Fly   564 GR------------GTARTR-AGATAATRGKGQLDVTVSSTRT--------SGRQQTLLSSLMGS 607
            ||            |:.|.| .|...:|||:.. ..|.|::|.        |.|||.  |..:.:
  Rat   575 GRRGGRGQSTAPRGGSQRGRDTGLGISTRGRSS-KATASTSRNMSIIDAFRSTRQQP--SRNVAT 636

  Fly   608 RNTASYVISDDSD 620
            :|.:..:..|:||
  Rat   637 KNYSETIEVDESD 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mre11	NP_523547.1	mre11	13..413	CDD:273153	201/399 (50%)
		MPP_Mre11_N	16..288	CDD:277319	149/271 (55%)
		Mre11_DNA_bind	308..469	CDD:282063	58/162 (36%)
Mre11	NP_071615.1	mre11	10..402	CDD:273153	201/402 (50%)
		MPP_Mre11_N	14..275	CDD:277319	149/271 (55%)
		Mre11_DNA_bind	295..462	CDD:282063	59/167 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	505..706		33/148 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339761
Domainoid	1	1.000	269	1.000	Domainoid score	I1778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4083
Inparanoid	1	1.050	445	1.000	Inparanoid score	I1585
OMA	1	1.010	-	-		QHG54350
OrthoDB	1	1.010	-	-		D207599at33208
OrthoFinder	1	1.000	-	-		FOG0005216
OrthoInspector	1	1.000	-	-		oto98190
orthoMCL	1	0.900	-	-		OOG6_101854
Panther	1	1.100	-	-	LDO	PTHR10139
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3730
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910