Protein Alignment mre11 and mre11a

DIOPT Version :9

• Sequence 1: NP_523547.1
• Gene: mre11 / 34565
• FlyBaseID: FBgn0020270
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_001307188.1
• Gene: mre11a / 406637
• ZFINID: ZDB-GENE-040426-2638
• Length: 700
• Species: Danio rerio
• Alignment Length: 664
• Identity: 259/664 - (39%)
• Similarity: 378/664 - (56%)
• Gaps: 71/664 - (10%)

  Fly     3 GTTTAEQDADNVIRILVATDNHLGYGEKDAVRGEDSFTAFEEILELAVSEDVDMILLGGDLFHDA 67
            |:|..::|   ..:||:|||.||||.||||:||.|:|..|:||::.|:..:||.:|||||||||.
Zfish     5 GSTVDDED---TFKILIATDIHLGYLEKDAIRGNDTFVTFDEIMKQAMQNEVDFVLLGGDLFHDN 66

  Fly    68 VPSQNALHKCIELLRRYTFGDRPVSLEILSDQGQCFHNAVNQSVNYEDPNLNIAIPVFSIHGNHD 132
            .||:..:|.|:|::|:|..||||:..||:|||...|.::....|||.|.||||:||:||:|||||
Zfish    67 KPSRKTMHSCMEVMRKYCMGDRPIIFEIISDQAVNFSHSRFPWVNYLDDNLNISIPIFSVHGNHD 131

  Fly   133 DPSGFGRLSSLDLLSTSGLVNYFGRWTDLTQVEISPVLMRKGESQLALYGLSHIHDGRLARLIKD 197
            ||:|...|.::||||.:||||:|||...:.:|||||||::||::::|||||..|.|.||.|:..:
Zfish   132 DPTGSDGLCAVDLLSCAGLVNHFGRSRSVEKVEISPVLLQKGDTRIALYGLGSIPDERLYRMFVN 196

  Fly   198 FKVKFNCPENVANGEDGNESKEEED-WFHLLVVHQNRADRGPKNYLPEDLLPSFLHLVIWGHEHD 261
            .:|....|            :|:|| ||:|.|:||||:..|..||:||..|..||.||:|||||:
Zfish   197 NQVTMLRP------------REDEDGWFNLFVIHQNRSKHGATNYIPEQFLDDFLDLVVWGHEHE 249

  Fly   262 CRIEPEENAKKRFYVSQPGSSVPTSLSEGEAKKKHVGLLEIYKGKFKLKPLPLETVRPFVYESVV 326
            |:|.|..|.::.|||:||||||.||||.|||.|||:|||.:...|..|:.:||:|||.|..:.||
Zfish   250 CKIAPVRNEQQLFYVTQPGSSVITSLSPGEAVKKHIGLLRVKGKKMNLQKIPLQTVRQFFIQDVV 314

  Fly   327 LADHADELGLVEGDASTKVFKFAQERVEAMIERAVAQHTGHPKQPTLPLIRLRLLYTDESCMFNA 391
            |:|:.:.....:.:...||..|.||:||.|:|.|..:..|:|:.|..||||||:.|:....:||.
Zfish   315 LSDYPELFSPEQPNTMLKVQAFCQEKVEEMLEEAERERLGNPQIPEKPLIRLRVDYSGGFEVFNT 379

  Fly   392 IRFGEMLSTRVANVQDVVQFSKVVKRTKTEA----VNLDKEAL-RRALEADNATRVEELVDRYFE 451
            :||.:....:|||.:|::.|   |:..:|:.    .::|.||| .|........|||:||..||:
Zfish   380 MRFSQKFVDKVANPKDILHF---VRHRETKGNIKDEDVDFEALFSRPTSEVLQLRVEDLVKEYFQ 441

  Fly   452 EAKSNKPLKLFHSKALAEMTYRLLEQRDADAAENIVKFYKEKAVDHLMEAM--PNDENIDEELER 514
            .|:.|..|.|...:.:.:.....:::.:.||.|.::.:..||...:|.|..  ..:|.||||:.:
Zfish   442 TAEKNVQLSLLTEQGMGKAVQEFVDKEERDAIEELINYQLEKTQRYLRERRVDATEEKIDEEIRQ 506

  Fly   515 FRALHK------------------HGDLLKMLDTQGLKVKKEEKSMSVLGSEVNVSTAPATGRG- 560
            ||...:                  |.|..:......|.:..:...:::...|...|..|..|||
Zfish   507 FRDSKRNTAEEDEEVQEAIIRAKAHRDRGETARDDDLGLSDDPADIAMESDEEPSSAPPVRGRGR 571

  Fly   561 AARG--------RGTAR---TRAGATAATRG--------KGQLDVTVSSTRTSGRQQTLLSSLMG 606
            .:||        ||.||   :|:|.....||        |..:||....::.|.|.:|
Zfish   572 GSRGGRDPCASKRGRARGAASRSGRGGRGRGSLSSPVKTKSIMDVFQDVSQRSTRGKT------- 629

  Fly   607 SRNTASYVISDDSD 620
            .::.|..:..:|||
Zfish   630 PKSYAEEITIEDSD 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mre11	NP_523547.1	mre11	13..413	CDD:273153	195/400 (49%)
		MPP_Mre11_N	16..288	CDD:277319	143/272 (53%)
		Mre11_DNA_bind	308..469	CDD:282063	58/165 (35%)
mre11a	NP_001307188.1	Mre11_DNA_bind	11..403	CDD:332009	197/409 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579552
Domainoid	1	1.000	266	1.000	Domainoid score	I1850
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4083
Inparanoid	1	1.050	436	1.000	Inparanoid score	I1658
OMA	1	1.010	-	-		QHG54350
OrthoDB	1	1.010	-	-		D207599at33208
OrthoFinder	1	1.000	-	-		FOG0005216
OrthoInspector	1	1.000	-	-		oto38628
orthoMCL	1	0.900	-	-		OOG6_101854
Panther	1	1.100	-	-	LDO	PTHR10139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3730
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910