DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mre11 and rad32

DIOPT Version :9

Sequence 1:	NP_523547.1	Gene:	mre11 / 34565	FlyBaseID:	FBgn0020270	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_592935.1	Gene:	rad32 / 2542757	PomBaseID:	SPAC13C5.07	Length:	649	Species:	Schizosaccharomyces pombe

Alignment Length:	613	Identity:	231/613 - (37%)
Similarity:	343/613 - (55%)	Gaps:	48/613 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DNVIRILVATDNHLGYGEKDAVRGEDSFTAFEEILELAVSEDVDMILLGGDLFHDAVPSQNALHK 76
            :|.||||:::|.|:||||||.|||.|||.:|.||||:|...||||||||||:|||..||:.||::
pombe    15 ENTIRILISSDPHVGYGEKDPVRGNDSFVSFNEILEIARERDVDMILLGGDIFHDNKPSRKALYQ 79

  Fly    77 CIELLRRYTFGDRPVSLEILSDQGQCFHNAVNQSVNYEDPNLNIAIPVFSIHGNHDDPSGFGRLS 141
            .:..||....||:|..||:|||......:....::||.|||:|:||||||||||||||||.||.|
pombe    80 ALRSLRLNCLGDKPCELELLSDTSLTTGDTAVCNINYLDPNINVAIPVFSIHGNHDDPSGDGRYS 144

  Fly   142 SLDLLSTSGLVNYFGRWTDLTQVEISPVLMRKGESQLALYGLSHIHDGRLARLIKDFKVKFNCPE 206
            :||:|..:||||||||..:...:.:||:|::||.::|||||:|::.|.||....::.||||..|:
pombe   145 ALDILQVTGLVNYFGRVPENDNIVVSPILLQKGFTKLALYGISNVRDERLYHSFRENKVKFLRPD 209

  Fly   207 NVANGEDGNESKEEEDWFHLLVVHQNRADRGPKNYLPEDLLPSFLHLVIWGHEHDCRIEPEENAK 271
                       ...::||:||.||||.:...|.:||||..:..|...|:|||||:|.|:...|..
pombe   210 -----------LYRDEWFNLLTVHQNHSAHTPTSYLPESFIQDFYDFVLWGHEHECLIDGSYNPT 263

  Fly   272 KRFYVSQPGSSVPTSLSEGEAKKKHVGLLEIYKGKFKLKPLPLETVRPFVYESVVLADHADELGL 336
            ::|.|.||||::.||||.||...||.|:|.|....|.|:.:.|.|||||:.:.::|::.:....:
pombe   264 QKFTVVQPGSTIATSLSPGETAPKHCGILNITGKDFHLEKIRLRTVRPFIMKDIILSEVSSIPPM 328

  Fly   337 VEGDASTKVFKFAQERVEAMIERAVAQ--------HTGHPKQPTLPLIRLRLLYTDESCMFNAIR 393
            ||.  ..:|..:...:||..|..|.||        .....::|.|||||||:.||......|..|
pombe   329 VEN--KKEVLTYLISKVEEAITEANAQWYEAQGTVPVVENEKPPLPLIRLRVDYTGGYQTENPQR 391

  Fly   394 FGEMLSTRVANVQDVVQFSKVVKRTKTEAVNLDKEALRRALEAD---NATRVEELVDRYFEEAKS 455
            |......||||..|||||....|.|:::.    .:.|..:...|   |:.|||.||:.|.   |:
pombe   392 FSNRFVGRVANATDVVQFYLKKKYTRSKR----NDGLYTSAVEDIKINSLRVESLVNEYL---KT 449

  Fly   456 NKPLKLFHSKALAEMTYRLLEQRDADAAENIVKFYKEKAVDHLMEAMPNDENIDEELERFRALHK 520
            |: |:.....:|.|.....:|:.|.||.:..|:....|.::.|::....:||:::|:...
pombe   450 NR-LECLPEDSLGEAVVNFVEKDDRDAIKECVETQLNKQINLLVKKRVTEENLEQEISSI----- 508

  Fly   521 HGDLLKMLDTQGLKVKKEEKSMSVLGSEVNVSTAPATGRGAARGRGTARTRAGATAATRGKGQLD 585
            ..||.|:..|:    :|:.:.:....||.:::.|..|  ...:...:........|.:..:.:::
pombe   509 INDLPKISTTK----RKDYEELPEEVSETSINIAEHT--PVLKHTSSLLDHHSPLATSSSEHEME 567

  Fly   586 VTVSST---RTSGRQQTLLSSLMGSRNT 610
            .|.|..   :|:.|::  |.|.:..:||
pombe   568 ATPSPALLKKTNKRRE--LPSSLTKKNT 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mre11	NP_523547.1	mre11	13..413	CDD:273153	187/407 (46%)
		MPP_Mre11_N	16..288	CDD:277319	136/271 (50%)
		Mre11_DNA_bind	308..469	CDD:282063	54/171 (32%)
rad32	NP_592935.1	mre11	15..414	CDD:273153	187/411 (45%)
		MPP_Mre11_N	19..280	CDD:277319	136/271 (50%)
		Mre11_DNA_bind	301..467	CDD:282063	55/175 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	261	1.000	Domainoid score	I367
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4083
Inparanoid	1	1.050	376	1.000	Inparanoid score	I430
OMA	1	1.010	-	-		QHG54350
OrthoFinder	1	1.000	-	-		FOG0005216
OrthoInspector	1	1.000	-	-		oto101828
orthoMCL	1	0.900	-	-		OOG6_101854
Panther	1	1.100	-	-	LDO	PTHR10139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1060
SonicParanoid	1	1.000	-	-		X3730
TreeFam	0	0.000	Not matched by this tool.
	12	12.000