DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mre11 and mre-11

DIOPT Version :9

Sequence 1:	NP_523547.1	Gene:	mre11 / 34565	FlyBaseID:	FBgn0020270	Length:	620	Species:	Drosophila melanogaster
Sequence 2:	NP_505736.2	Gene:	mre-11 / 179488	WormBaseID:	WBGene00003405	Length:	728	Species:	Caenorhabditis elegans

Alignment Length:	684	Identity:	240/684 - (35%)
Similarity:	342/684 - (50%)	Gaps:	145/684 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GTTTAEQDADNVIRILVATDNHLGYGEKDAVRGEDSFTAFEEILELAVSEDVDMILLGGDLFHDA 67
            |...|..:::::|:||||||.|.||||..|....|:...|||:|::|..:.||||||||||||:.
Worm    54 GDEPAHDESEDIIKILVATDIHCGYGENKANIHMDAVNTFEEVLQIATEQKVDMILLGGDLFHEN 118

  Fly    68 VPSQNALHKCIELLRRYTFGDRPVSLEILSDQGQCFHNAVNQSVNYEDPNLNIAIPVFSIHGNHD 132
            .||:...|:..:|||:|.....|::||.|||....|:.:|...|||.|.|||:.:|:|:||||||
Worm   119 NPSREVQHRVTQLLRQYCLNGNPIALEFLSDASVNFNQSVFGHVNYYDQNLNVGLPIFTIHGNHD 183

  Fly   133 DPSGFGRLSSLDLLSTSGLVNYFGRWTDLTQVEISPVLMRKGESQLALYGLSHIHDGRLARLIKD 197
            |.||.| |::||||..|||||.||:.:::.:..:||:|:||||::|||||:....|.||.|..|:
Worm   184 DLSGKG-LTALDLLHESGLVNLFGKHSNIQEFIVSPILLRKGETRLALYGIGSQRDDRLVRAFKN 247

  Fly   198 FKVKFNCPENVANGEDGNESKEEEDWFHLLVVHQNR----ADRGPKNYLPEDLLPSFLHLVIWGH 258
            ..:.|..|...|           ||||:|.|:||||    ..|...|:|||.|:|.|..|:||||
Worm   248 NSISFLRPNAGA-----------EDWFNLFVLHQNRPRRAMHRSTGNFLPESLIPQFFDLLIWGH 301

  Fly   259 EHDCRIEPEENAKKR-----FYVSQPGSSVPTSLSEGEAKKKHVGLLEIYKGKFKLKPLPLETVR 318
            ||:|:.:|:..|...     ||:.||||:|.|||:..||.:|:..|::|...||..||:||:|||
Worm   302 EHECKPDPQYVASSEAVGDGFYILQPGSTVATSLTPEEALQKNAFLIKIKGRKFASKPIPLQTVR 366

  Fly   319 PFVYESVVL--------------------ADHADELGLVEGDASTKVFKFAQERVEAMIERAVAQ 363
            |.|.:.::|                    ..:.||:.:             :.::..||..|.|:
Worm   367 PMVCDELLLDKIPPGSRPILKTDRPKHTDGRYIDEIAI-------------EAKINEMITTAKAK 418

  Fly   364 HTGHPKQPTLPLIRLRLLYTDESCMF---NAIRFGEMLSTRVANVQDVVQFSKVVKRTKTEAVNL 425
            .  .|:||.||||||:::|..:....   ||.|.|......|||..|:| |.|  |..|.:...|
Worm   419 R--RPRQPELPLIRLKVIYDGDWLNITPANAKRIGLRYENVVANAVDMV-FIK--KNNKPKEGKL 478

  Fly   426 DKEALRRALE-AD-----NATRVEELVDRYFEEAKSNKPLKLFHSKALAEMTY-------RLLEQ 477
            ..|..:...| ||     :||.::.:::.||    .|:||       :.:||.       |.|||
Worm   479 QTENEKNITEMADEMGQVSATNLQTIINDYF----INQPL-------VDQMTVLKPIGIGRALEQ 532

  Fly   478 RDA--------DAAENI--VKFYKEKAVDHLMEAMP----NDENIDEELERFRALHKHGDL--LK 526
            ..|        .|..|.  ...::...|...::.||    ||.:   :|::||.|... ||  :|
Worm   533 YSAIEEGGLATSANRNFDSCLMHQIDVVRKTLKKMPLPPINDPS---DLDKFRDLITK-DLYDMK 593

  Fly   527 MLDTQGLK-----VKKEE----------------------------KSMSVLGSEVNVSTAPATG 558
            ..|::..|     |:.||                            .|...:||.::..:...|.
Worm   594 KADSERFKNPVADVEMEEDEDDPQYYMPPQSTSRTNYASGSEDEVANSDEEMGSSISRHSKQPTT 658

  Fly   559 RGAARGRGTARTRAGATAATRGKGQLDVTVSSTR 592
            ||  |||| ||....:...|||:..   .|.|||
Worm   659 RG--RGRG-ARGAGASRETTRGRSN---KVVSTR 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mre11	NP_523547.1	mre11	13..413	CDD:273153	178/431 (41%)
		MPP_Mre11_N	16..288	CDD:277319	133/280 (48%)
		Mre11_DNA_bind	308..469	CDD:282063	51/189 (27%)
mre-11	NP_505736.2	mre11	63..472	CDD:273153	180/438 (41%)
		MPP_Mre11_N	67..335	CDD:277319	132/279 (47%)
		Mre11_DNA_bind	358..533	CDD:282063	56/203 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158784
Domainoid	1	1.000	235	1.000	Domainoid score	I1324
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4083
Inparanoid	1	1.050	314	1.000	Inparanoid score	I1534
Isobase	1	0.950	-	0	Normalized mean entropy	S1306
OMA	1	1.010	-	-		QHG54350
OrthoDB	1	1.010	-	-		D207599at33208
OrthoFinder	1	1.000	-	-		FOG0005216
OrthoInspector	1	1.000	-	-		oto20607
orthoMCL	1	0.900	-	-		OOG6_101854
Panther	1	1.100	-	-	LDO	PTHR10139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1060
SonicParanoid	1	1.000	-	-		X3730
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890