Protein Alignment mre11 and Mre11a

DIOPT Version :9

• Sequence 1: NP_523547.1
• Gene: mre11 / 34565
• FlyBaseID: FBgn0020270
• Length: 620
• Species: Drosophila melanogaster
• Sequence 2: NP_061206.1
• Gene: Mre11a / 17535
• MGIID: 1100512
• Length: 706
• Species: Mus musculus
• Alignment Length: 664
• Identity: 271/664 - (40%)
• Similarity: 381/664 - (57%)
• Gaps: 75/664 - (11%)

  Fly    10 DADNVIRILVATDNHLGYGEKDAVRGEDSFTAFEEILELAVSEDVDMILLGGDLFHDAVPSQNAL 74
            |.::..:||||||.|||:.|||||||.|:|..|:|||.||:..:||.|||||||||:..||:..|
Mouse     8 DDEDTFKILVATDIHLGFMEKDAVRGNDTFVTFDEILRLALENEVDFILLGGDLFHENKPSRKTL 72

  Fly    75 HKCIELLRRYTFGDRPVSLEILSDQGQCFHNAVNQSVNYEDPNLNIAIPVFSIHGNHDDPSGFGR 139
            |.|:||||:|..|||||..|::|||...|..:....|||:|.||||:|||||||||||||:|...
Mouse    73 HSCLELLRKYCMGDRPVQFEVISDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADA 137

  Fly   140 LSSLDLLSTSGLVNYFGRWTDLTQVEISPVLMRKGESQLALYGLSHIHDGRLARLIKDFKVKFNC 204
            |.:||:||.:|.||:|||...:.:|:|||||::||.::||||||..|.|.||.|:..:.||....
Mouse   138 LCALDVLSCAGFVNHFGRSMSVEKVDISPVLLQKGSTKLALYGLGSIPDERLYRMFVNKKVTMLR 202

  Fly   205 PENVANGEDGNESKEEEDWFHLLVVHQNRADRGPKNYLPEDLLPSFLHLVIWGHEHDCRIEPEEN 269
            |:           ::|..||:|.|:||||:..|..|::||..|..|:.||||||||:|:|.|.:|
Mouse   203 PK-----------EDENSWFNLFVIHQNRSKHGNTNFIPEQFLDDFIDLVIWGHEHECKIGPIKN 256

  Fly   270 AKKRFYVSQPGSSVPTSLSEGEAKKKHVGLLEIYKGKFKLKPLPLETVRPFVYESVVLADHADEL 334
            .::.||||||||||.||||.|||.|||||||.|...|..::.|||.|||.|..|.||||:|.:..
Mouse   257 EQQLFYVSQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMQKLPLRTVRRFFIEDVVLANHPNLF 321

  Fly   335 GLVEGDASTKVFKFAQERVEAMIERAVAQHTGHPKQPTLPLIRLRLLYTDESCMFNAIRFGEMLS 399
            .......:..:..|..|::|.|::.|..:..|:|:||..||||||:.|:.....||.:||.:...
Mouse   322 NPDNPKVTQAIQSFCLEKIEEMLDSAERERLGNPQQPGKPLIRLRVDYSGGFEPFNVLRFSQKFV 386

  Fly   400 TRVANVQDVVQFSK-VVKRTKT-EAVNLDKEALRRALEADNAT-RVEELVDRYFEEAKSNKPLKL 461
            .||||.:||:.|.: ..::.|| |.:|......:.|  ::.|| |||:||.:||:.|:.|..|.|
Mouse   387 DRVANPKDVIHFFRHREQKGKTGEEINFGMLITKPA--SEGATLRVEDLVKQYFQTAEKNVQLSL 449

  Fly   462 FHSKALAEMTYRLLEQRDADAAENIVK--------FYKEKAVDHLMEAMPNDENIDEELERFR-- 516
            ...:.:.|.....:::.:.||.|.:||        |.||:.:|.|      ::.||||:.|||
Mouse   450 LTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDAL------EDKIDEEVRRFRES 508

  Fly   517 --------------ALHKHGDLLKMLDTQGLKVKKEEKS-----MSVLGSEVNVSTAPATGRGAA 562
                          |:.:...|....:|.......|:.|     .:...|:.::|..|:.|||..
Mouse   509 RQRNTNEEDDEVREAMSRARALRSQSETSTSAFSAEDLSFDTSEQTANDSDDSLSAVPSRGRGRG 573

  Fly   563 RGRGTARTRAGATAATRGKGQ------LDVTV-----SSTRTSGRQQTLLSSLMGSR-------- 608
            |||..||   |.::|.||..|      |::|.     .:|.::.|..:::.:...:|
Mouse   574 RGRRGAR---GQSSAPRGGSQRGRDTGLEITTRGRSSKATSSTSRNMSIIDAFRSTRQQPSRNVA 635

  Fly   609 --NTASYVISDDSD 620
              |.:..:..||||
Mouse   636 PKNYSETIEVDDSD 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mre11	NP_523547.1	mre11	13..413	CDD:273153	203/399 (51%)
		MPP_Mre11_N	16..288	CDD:277319	149/271 (55%)
		Mre11_DNA_bind	308..469	CDD:282063	58/163 (36%)
Mre11a	NP_061206.1	Mre11_DNA_bind	10..402	CDD:391699	203/402 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	505..706		33/148 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836096
Domainoid	1	1.000	269	1.000	Domainoid score	I1838
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4083
Inparanoid	1	1.050	450	1.000	Inparanoid score	I1600
Isobase	1	0.950	-	0	Normalized mean entropy	S1306
OMA	1	1.010	-	-		QHG54350
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005216
OrthoInspector	1	1.000	-	-		oto94682
orthoMCL	1	0.900	-	-		OOG6_101854
Panther	1	1.100	-	-	LDO	PTHR10139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3730
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.850