DRSC/TRiP Functional Genomics Resources

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Protein Alignment ab and ZBTB37

DIOPT Version :9

Sequence 1:NP_476562.1 Gene:ab / 34560 FlyBaseID:FBgn0264442 Length:904 Species:Drosophila melanogaster
Sequence 2:NP_001116242.1 Gene:ZBTB37 / 84614 HGNCID:28365 Length:503 Species:Homo sapiens


Alignment Length:615 Identity:133/615 - (21%)
Similarity:207/615 - (33%) Gaps:175/615 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 DFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILRDVR 148
            ||.:|:||....||.:....|:.:....::|.||||||:|.|||||..:..|  |...|.:..::
Human    13 DFSNSVLSHLNQLRMQGRLCDIVVNVQGQAFRAHKVVLAASSPYFRDHMSLN--EMSTVSISVIK 75

  Fly   149 CDDV-ENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSAALSHNSSNNNN 212
            ...| |.||||.|.|.:.:....:..:|..|..||::.:.|     ..::.|...          
Human    76 NPTVFEQLLSFCYTGRICLQLADIISYLTAASFLQMQHIID-----KCTQILEGI---------- 125

  Fly   213 NNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSSSNNIS 277
                                    |.||    :..:..|..:.:...:......||      .::
Human   126 ------------------------HFKI----NVAEVEAELSQTRTKHQERPPESH------RVT 156

  Fly   278 GSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQTSGTP 342
            .:||.||:...:.|:                                       ....||.|...
Human   157 PNLNRSLSPRHNTPK---------------------------------------GNRRGQVSAVL 182

  Fly   343 AIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPPPQKRIKSADLFRAQHGISP 407
            .|:||     :.|..:.:|...:.||    |:...|          |..||..|..:..:.|::.
Human   183 DIREL-----SPPEESTSPQIIEPSS----DVESRE----------PILRINRAGQWYVETGVAD 228

  Fly   408 ERLLLDREFPVAGQ-HPLTRN----------RSGRDTSKDRERNLELRESLLGQALENS-NGQQA 460
            .....|.|..|.|. |..|.|          .||.|.|.        .|.:....::.: :|...
Human   229 RGGRSDDEVRVLGAVHIKTENLEEWLGPENQPSGEDGSS--------AEEVTAMVIDTTGHGSVG 285

  Fly   461 NPKHELGQSAGEDSNSSDTE-----PS---------DRGDGQHDGTLDGIDNQRSHSFPNAFLGL 511
            ...:.||.|..:.:..:.:|     ||         .|...:..|.:|......|....:|.:|:
Human   286 QENYTLGSSGAKVARPTSSEVDRFSPSGSVVPLTERHRARSESPGRMDEPKQPSSQVEESAMMGV 350

  Fly   512 QGIPGLL-------------PGPSGI--NSDFVSRRSLEMRVR---ATDPRPCPKCGKIYRSAHT 558
            .|....|             |..:.|  ...|..:.||:..:|   ...|..|..|||.|.....
Human   351 SGYVEYLREQEVSERWFRYNPRLTCIYCAKSFNQKGSLDRHMRLHMGITPFVCRMCGKKYTRKDQ 415

  Fly   559 LRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPE--LASRL 621
            |..|:. |||....:.|.:||.....:..|:.|..:.|.|.    :| |..|.:..||  :.||.
Human   416 LEYHIR-KHTGNKPFHCHVCGKSFPFQAILNQHFRKNHPGC----IP-LEGPHSISPETTVTSRG 474

  Fly   622 LAKAGVKISPA--ELRARASPTGGSGSSGG 649
            .|:   :.||:  |..|......||.|:.|
Human   475 QAE---EESPSQEETVAPGEAVQGSVSTTG 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
abNP_476562.1 BTB 93..189 CDD:279045 31/96 (32%)
BTB 104..189 CDD:197585 29/85 (34%)
zf-Di19 545..597 CDD:283297 15/51 (29%)
C2H2 Zn finger 546..567 CDD:275371 7/20 (35%)
C2H2 Zn finger 575..596 CDD:275371 5/20 (25%)
ZBTB37NP_001116242.1 BTB_POZ_ZBTB37 7..129 CDD:349531 39/156 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..206 18/119 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 280..344 11/63 (17%)
C2H2 Zn finger 375..395 CDD:275368 5/19 (26%)
zf-H2C2_2 387..412 CDD:404364 9/24 (38%)
zf-C2H2 401..423 CDD:395048 7/22 (32%)
C2H2 Zn finger 403..423 CDD:275368 7/20 (35%)
zf-H2C2_2 416..438 CDD:404364 8/22 (36%)
C2H2 Zn finger 431..449 CDD:275368 5/17 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 457..503 16/49 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 99 1.000 Inparanoid score I5010
Isobase 1 0.950 - 0 Normalized mean entropy S11797
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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