Protein Alignment ab and BTBD18

DIOPT Version :10

• Sequence 1: NP_476562.1
• Gene: ab / 34560
• FlyBaseID: FBgn0264442
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_001138573.1
• Gene: BTBD18 / 643376
• HGNCID: 37214
• Length: 712
• Species: Homo sapiens
• Alignment Length: 797
• Identity: 169/797 - (21%)
• Similarity: 277/797 - (34%)
• Gaps: 192/797 - (24%)

  Fly    57 SPATP------PPSLNLSHQQQQHQQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFT 115
            |||:|      |..|.|:..|..|||         ||.:            |.||.|..:..:..
Human     3 SPASPKILYRNPRFLRLAFLQLHHQQ---------QSDV------------FCDVLLQAEGEAVP 46

  Fly   116 AHKVVLSACSPYF-RRLLKANPCEHPIVILR--DVRCDDVENLLSFMYNGEVNVSHEQLPDFLKT 177
            ||..:||||||:| .||.:..|.:...|:|.  .::...:..|:.|:|..|:.||.|:..|.|..
Human    47 AHCCILSACSPFFTERLERERPAQGGKVVLELGGLKISTLRKLVDFLYTSEMEVSQEEAQDVLSA 111

  Fly   178 AHLLQIRGL--ADVNGG----------------YPYSKALSAALSHNSSNNNNNNSSSN------ 218
            |..|::..|  ..:.||                .|.|.|..:|.....|::.:....:|
Human   112 ARQLRVSELESLQLEGGKLVKAPQGRRLNRECLQPTSAAPISARVVTPSHHPHTPLPTNQTPCPL 176

  Fly   219 -----NSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSSSNNISG 278
                 .||........||.:  |.:.:|..|...:.:.||......||:..|.|.....:.|.:.
Human   177 GAIRLKSLGKEEGPQENNRQ--NADNLSGTLLLKRKARACPTPQEKNSSPSSHSQEPRENKNDTA 239

  Fly   279 SLNSSLNSPFSAPQI-----PPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQT 338
            ...:.|:.|...|.:     |..:..|.:..:.....|..:::.:.:::..|:.|..........
Human   240 LDPTVLSPPSLYPSVDKHLLPRKIRLSRSKPSPGICTSKPSSILSGSSSVPATPGRRLWRQRSVN 304

  Fly   339 SGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPPPQKRIKSADLFRAQH 403
            ..||  ::......|||::: .||||        .:|:..||||.    .|:.|..::|  .|:.
Human   305 KETP--EDKPKPGRASPLQS-TPNPS--------GLGKTGGSRKR----SPEVRAPNSD--SAEE 352

  Fly   404 G----ISPERLLLDREFPVAGQHPLTRNRSGRDTSKDRERNLELRESLLGQALENSNGQQANP-K 463
            |    :...:::....:.|..:.||   ::.:|:.:..:...:.:|. .|....:||.|:.:| :
Human   353 GQVGRVKLRKIVNGTCWEVVQETPL---KNTQDSPQIPDPGGDFQEP-SGTQPFSSNEQEMSPTR 413

  Fly   464 HELGQSAGEDSNSSDTEPSDRGDGQHDGTLDGIDNQRSHSFPNAFLGLQGIPGLLPGPSGINSDF 528
            .||.|                 |......|..|....|||               |....:.|:|
Human   414 TELCQ-----------------DSPMCTKLQDILVSASHS---------------PDHPVVKSEF 446

  Fly   529 VSRRSLEMRVRATDPRPCPKCGKIYRSAHTLRTHLEDKHTVCPGYRC---------------VLC 578
            .|...|..:    :|.....|    |..:...|.|.::......||.               :||
Human   447 ESSPELVEK----EPMLAIDC----REPYAFDTALLEQPCEAEEYRITSAAATSELEEILDFMLC 503

  Fly   579 GT-VAKSRNSLHS-----------HMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKAGVKISP 631
            |: :.....||.|           |::...:.....:...||....:..||.......||....|
Human   504 GSDIEPPIGSLESPGAEGCRTPTYHLTETGKNWIEGEEWCLPDMELWPRELTELEKEPAGENRGP 568

  Fly   632 AELRA-RASPTGGSGSSGGGGGGGSSQAKLDLSNASGGPMDDAED------SDDDPE-------- 681
            .||.: ...|:..|.....||     :...||...|..|:|..||      |.|.|:
Human   569 TELLSPLVMPSEVSEVLSVGG-----RWTPDLEITSSQPLDGQEDKLLHVSSLDTPQRSYGDLSP 628

  Fly   682 ------------DLTTGNGLYGMGGSSSDLSRYHESLLSNFGHARMRNEAAAVAATAAALGQPKD 734
                        .|||...||....:..::|. |..||.:...:....|...|..||.....|..
Human   629 PCSNWVETGLEVSLTTDELLYPSPKAGKEVSG-HSELLGSLPASSEEEEIDVVDWTAEGRLVPTT 692

  Fly   735 LGVQLPNSNAPGQSLLD 751
            :....|:.::..::.:|
Human   693 VPSVWPDPSSESETEVD 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB_POZ_BAB-like	102..185	CDD:349624	29/85 (34%)
		zf-Di19	545..597	CDD:428539	13/78 (17%)
		C2H2 Zn finger	546..567	CDD:275371	4/20 (20%)
		C2H2 Zn finger	575..596	CDD:275371	7/47 (15%)
BTBD18	NP_001138573.1	BTB_POZ_BTBD18	19..138	CDD:349602	39/139 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..176		2/18 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..355		34/159 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..410		8/39 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..676		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..712		2/19 (11%)