DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and zbtb37

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001038625.1	Gene:	zbtb37 / 568471	ZFINID:	ZDB-GENE-050208-621	Length:	521	Species:	Danio rerio

Alignment Length:	630	Identity:	136/630 - (21%)
Similarity:	214/630 - (33%)	Gaps:	166/630 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 DFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILRDVR 148
            ||.:|:||....||.:....|:.:.....||.||||||:|.|||||..:..:  |...|.:..:|
Zfish    13 DFSNSVLSHLNQLRIQGRLCDIVVNVQGHSFRAHKVVLAASSPYFRDHMSLS--EMSTVSISVIR 75

  Fly   149 CDDV-ENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLAD----VNGGYPYSKALSAAL----- 203
            ...| |.||||.|.|.:.:....:..:|..|..||::.:.|    :..|..:..:||...
Zfish    76 NPTVFEQLLSFCYTGRLCLQLADIISYLTAASFLQMQHIIDRCTQILEGIHFKISLSDVEEELGN 140

  Fly   204 -SHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSS 267
             :|.::|....:.....:||.:.:                 |||..|
Zfish   141 GAHRTTNQTIESGRGGTTLSGSRS-----------------LSPRLT------------------ 170

  Fly   268 HNNSSSNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSS 332
                ||..|..:...|:.......:|.||                               |.|.|
Zfish   171 ----SSRLIGNTGVISIRDVREVREISPP-------------------------------GESMS 200

  Fly   333 AASGQTSGTPAIQELKASSAASPVRNPNPNPSKASSSNHW--DMGEMEGSRKSHLTPPPQKRIKS 395
            ....:.||   |...:..|...|:...|       .:..|  :.|. |..|..      ::.::.
Zfish   201 PQIVEHSG---IGSEEVGSGKEPILRIN-------RAGQWYVETGP-EAERGG------EENVRM 248

  Fly   396 ADLFRAQHGISPERLLLDREFPVAGQHPLTRNRSGRDTSKDRERNLELRESLLGQALENSNGQQA 460
            .|.||    |..||:   .|:..|.........||.:.......:...|.:|:   .|...|
Zfish   249 VDGFR----IKTERM---DEWMGAETQASAEEGSGAEEGPTVMIDTSGRSTLV---QEGGRG--- 300

  Fly   461 NPKHELGQSAGEDSNSSDTE---PS---------DRGDGQHDGTLDGIDNQRSHSFPNAFLGLQG 513
                  |:|:...|:.|:||   |:         .|...:..|.:|...:..|.....|...:.|
Zfish   301 ------GKSSQPSSSFSETERFSPTGSVVVMADRQRAKSESPGRVDDQRHPTSQGEEQAVFDMGG 359

  Fly   514 IPGLLPGPSGIN--------------SDFVSRRSLEMRVR---ATDPRPCPKCGKIYRSAHTLRT 561
            ....|....|..              ..|..:.||:..:|   ...|..|..|||.|.....|..
Zfish   360 YEEYLREQVGDRWFRYNPRLTCIYCCKSFNQKGSLDRHMRLHMGITPFVCRICGKKYTRKDQLEY 424

  Fly   562 HLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKAG 626
            |:. |||....:.|.:||.....:..|:.|..:.|.|.:.::     :..:..|| .:.:.::.|
Zfish   425 HIR-KHTGNKPFHCHVCGKSFPFQAILNQHFRKNHPGCAPQE-----VSHSASPE-TTTVTSRGG 482

  Fly   627 VK--ISPAELRARASPTGGSGSSGGGGGGGSSQAKLDLSNASGGP 669
            ..  .||::..|       .|:.||||.|.|....:..|.::.||
Zfish   483 QNEDESPSQEEA-------EGNGGGGGAGSSFGEGVQPSVSTTGP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	33/100 (33%)
		BTB	104..189	CDD:197585	31/89 (35%)
		zf-Di19	545..597	CDD:283297	15/51 (29%)
		C2H2 Zn finger	546..567	CDD:275371	7/20 (35%)
		C2H2 Zn finger	575..596	CDD:275371	5/20 (25%)
zbtb37	NP_001038625.1	BTB	22..122	CDD:279045	33/101 (33%)
		BTB	33..123	CDD:197585	31/91 (34%)
		C2H2 Zn finger	381..401	CDD:275368	4/19 (21%)
		zf-H2C2_2	393..418	CDD:290200	9/24 (38%)
		zf-C2H2	407..429	CDD:278523	7/22 (32%)
		C2H2 Zn finger	409..429	CDD:275368	7/20 (35%)
		zf-H2C2_2	422..444	CDD:290200	8/22 (36%)
		C2H2 Zn finger	437..455	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I4989
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050