DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and br

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	1062	Identity:	268/1062 - (25%)
Similarity:	363/1062 - (34%)	Gaps:	410/1062 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHP 140
            ||:.|:||::||||.|:|.:|||:|.||||||||:.||..||:|||||||||||.|||:.||:||
  Fly     5 QHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKHP 69

  Fly   141 IVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTA------------------HLLQIRGLA 187
            :::|:||...|:..|:.|:|:|||||..:.|..|||||                  ||.||:.||
  Fly    70 VILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQNLA 134

  Fly   188 DVNGGYPY--------------------------------------------------------- 195
            :..|..|.
  Fly   135 NSGGRTPLNTHTQSLPHPHHGSLHDDGGSSTLFSRQGAGSPPPTAVPSLPSHINNQLLKRMAMMH 199

  Fly   196 -----------------------SKALSAALSHNSSNN--------------------------- 210
                                   |..||.|:...|:||
  Fly   200 RSSAAAAAEETSHAFKRLRGSDNSLPLSGAVGSGSNNNSPDLPPLHARSASPQQTPADFSTIKHH 264

  Fly   211 NNNNS----------SSNNSLSNNNNNNNNNAESSNHNKISSYL-----SPNQTSAA-------- 252
            ||||:          .:.|..|.|.|.|.|.|.:.|...||..|     ||...:.|
  Fly   265 NNNNTPPLKEEKRNGPTGNGNSGNGNGNGNGASNGNGISISDKLGSLTPSPLARAGADDVKSEPM 329

  Fly   253 ---C-NNSSNSN---SNNHSSSHN---NSSSNNISGSLNS--------SLNSPFSAPQ-IPPPVT 298
               | ||::|:|   ||:.:..|:   :||.:...|||:|        .|.|..:||| |..|..
  Fly   330 DMVCSNNNANANDEHSNDSTGEHDANRSSSGDGGKGSLSSGNDEEIGDGLASHHAAPQFIMSPAE 394

  Fly   299 ASSAAAAA--------AAAASL-TAAVAAAAAATAASAGSSSSAAS-----GQTSGTPAIQELKA 349
            .....|||        :|...| |....:...|.:...||:.|..|     |.:.|||:
  Fly   395 NKMFHAAAFNFPNIDPSALLGLNTQLQQSGDLAVSPQGGSTGSLLSGVIVPGGSGGTPS------ 453

  Fly   350 SSAASPVRNPNPNPSKASSSNHWDMGEMEGS------RKSHLTP---PPQKR----------IKS 395
                    |.:.|.:..:|:|.....|.:.|      ::.|.||   .||.:          .||
  Fly   454 --------NSSSNNNNNNSNNQQQKVEQQSSPHQLLQQQHHSTPHTNSPQLKQEQPKSGGGSCKS 510

  Fly   396 ADLFRAQ------------------HGISPERLLLDREFPVAGQHPLTRNRS---------GRDT 433
            :||..|.                  |..:|.        |.|..|...|.|.         .|:.
  Fly   511 SDLHIAAGSERSLSRSSQGMPDAGGHSATPS--------PTAAYHKRERERERERERERERERER 567

  Fly   434 SKDRERNLE-------------LRESLLGQ---ALENSNGQQANPKHELGQSAGEDSNSSDTEPS 482
            |.|.||:||             ...|..||   :|..|:.|.....|||..:|...:::
  Fly   568 SLDHERDLERPGGTGSPPPPPPSHHSHFGQHPLSLLPSHHQLHATHHELSAAAAHHAHA------ 626

  Fly   483 DRGDGQHDGTLDG----------IDNQRSHSFPNAFL----GLQGIPGLLPGPSGINSDFVSRRS 533
             .....|...|..          :.::|:...|:..:    |..|..|...||.|.....:|
  Fly   627 -HAHAAHAHALARAGSPMEHHHLLHHRRASLSPSGAVSSASGAGGRGGGAGGPGGPGGSLLS--- 687

  Fly   534 LEMRVRATD---------PRP------CPKCGKIYRSAHTLRTHLEDKH------TVCPGYRCVL 577
               .|||.|         |.|      |..|||:..:..||:.|.|.:|      .||.     |
  Fly   688 ---SVRAQDVAQANRLLLPLPLNACHRCDVCGKLLSTKLTLKRHKEQQHLQPLNNAVCN-----L 744

  Fly   578 CGTVAKSRNSLHSHMSRQHR-------------GISTKDLPVLPMPSAFDPELASRLLAKAGVKI 629
            |..|.::.|||::|.|..||             |:|....|            .|||..... .:
  Fly   745 CHKVFRTLNSLNNHKSIYHRRQKNHHSYFHHGAGVSQAGSP------------GSRLHQSLS-SL 796

  Fly   630 SPAELRARASPTGGSGSSGGGGG----------------------------GGSSQAKLDLSNAS 666
            |.|...|..|...|.||.||.||                            ||::.:.|.|:.|
  Fly   797 SAAAAAANNSVNVGGGSVGGAGGNAVAAAAAAAAAAAELLLSPIVGAAAVAGGTASSTLQLAAA- 860

  Fly   667 GGPMDDAEDSDDDPEDLTTGNGLYGMGGSSSDLSRYHESLLSNFGHARMRNEAAAVAATAAAL-- 729
                ...:.....|          |:.....|.. ..:.||....|..:.|.|||.||.|||.
  Fly   861 ----HQQQQQQSSP----------GIVKPCMDFLXDQQQLLQQLFHVALNNSAAAAAAAAAAAAA 911

  Fly   730 ----GQPKDLGVQLPNSNAPGQS-----------LLDTYLQFITENTFGMGMSQEQAAAAALRAK 779
                |.|..:|....:.|..||.           .:|  |..:.....|.|.|    |||||:..
  Fly   912 GGSGGGPGGVGAGPESINGGGQEYGGVQGPSGTPTVD--LTQLEHAAGGGGFS----AAAALQHH 970

  Fly   780 MAQLNAMGHSLDNLPPGLLPGQ 801
            :....|..|.:.:..|..|..|
  Fly   971 LPHHLAHQHPMSHQHPHQLTHQ 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	59/113 (52%)
		BTB	104..189	CDD:197585	52/102 (51%)
		zf-Di19	545..597	CDD:283297	20/63 (32%)
		C2H2 Zn finger	546..567	CDD:275371	8/20 (40%)
		C2H2 Zn finger	575..596	CDD:275371	8/20 (40%)
br	NP_001162638.2	BTB	22..118	CDD:279045	53/95 (56%)
		BTB	33..118	CDD:197585	46/84 (55%)
		C2H2 Zn finger	712..729	CDD:275368	6/16 (38%)
		C2H2 Zn finger	742..763	CDD:275368	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020