DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and bab2

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	1073	Identity:	259/1073 - (24%)
Similarity:	379/1073 - (35%)	Gaps:	360/1073 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TESTQLQTAENNNAGVVKMEPPPPATSSVSVSAAAAAH-----ALSSLSSLTMAAT--------- 52
            ||..:.:.:..|:..:.  .||.|.|||..|......|     .|.:..|.::..:
  Fly    94 TELVKSKASPMNDQALT--PPPRPLTSSEVVGLRDPEHTELRMCLEAKKSRSLPVSPQPQPNLKL 156

  Fly    53 -GSAL----------------SPATPPPSLNLSHQQQQHQQHYALKWNDFQSSILSSFRHLRDEE 100
             ||||                :|.|.||...:.....:.|| :.|:||::||::.:.|..|...|
  Fly   157 AGSALFEFGQRSSPVETKIKTNPETKPPRRKIVPPSGEGQQ-FCLRWNNYQSNLTNVFDELLQSE 220

  Fly   101 DFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILRDVRCDDVENLLSFMYNGEVN 165
            .||||||:|:..|..|||:|||||||||:.|...|||:|||:|:|||...|::.|:.|||.||:|
  Fly   221 SFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIIMRDVSWSDLKALVEFMYKGEIN 285

  Fly   166 VSHEQLPDFLKTAHLLQIRGLADVNGG--------YPYS--------KALSAA------------ 202
            |..:|:...||.|..|:|||||:|:.|        .|.|        :.|::|
  Fly   286 VCQDQINPLLKVAETLKIRGLAEVSAGRGEGGASALPMSAFDDEDEEEELASATAILQQDGDADP 350

  Fly   203 ----------------LSHNSSNNNNNNSSS----NNSLSNNNNNNNNNAESSNHNKISS----- 242
                            |..|......:...|    :.||....:..:....|....:..|
  Fly   351 DEEMKAKRPRLLPEGVLDLNQRQRKRSRDGSYATPSPSLQGGESEISERGSSGTPGQSQSQPLAM 415

  Fly   243 ---------YLSPN-QTSAACNNSSNSNSNNHSS------SHNNSSSNNISGS------LNSSLN 285
                     :.||| ||....|::.|:.:|...|      .|:|.:|.....|      :.|:|
  Fly   416 TTSTIVRNPFASPNPQTLEGRNSAMNAVANQRKSPAPTATGHSNGNSGAAMHSPPGGVAVQSAL- 479

  Fly   286 SPFSAPQIPPPVTA-----------SSAAAAAAAAASLTAAVAAAAAATAASAGS-SSSAASGQT 338
            .|..|..:|||.:|           ...|.:.|.|::|.||.|.|.||.|..||| |.|.||..|
  Fly   480 PPHMAAIVPPPPSAMHHHAQQLAAQHQLAHSHAMASALAAAAAGAGAAGAGGAGSGSGSGASAPT 544

  Fly   339 SGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDM------GEM--EGSRKSHLTPPPQKRIKS 395
            .||..     |.|.|          ..|..|:|.||      .||  |..|        .|.|:|
  Fly   545 GGTGV-----AGSGA----------GAAVGSHHDDMEIKPEIAEMIREEER--------AKMIES 586

  Fly   396 --------------------ADLFRAQ--------HGISPERLLLDREFPVAGQHPLTRNRSGRD 432
                                ||.::.|        ...:.:.|:....|...|  ||   :|.|.
  Fly   587 GGHGGWMGAAAAATGAASVAADSYQYQLQSMWQKCWNTNQQNLVQQLRFRERG--PL---KSWRP 646

  Fly   433 TSKDRERNLELRESLLGQALENSNGQQ------------ANPKHE-LGQSAGEDSNSSDTEPSDR 484
                 |...|...|:|.:.|..|...:            ||..|. ||.|.   ...:|..|..|
  Fly   647 -----EAMAEAIFSVLKEGLSLSQAARKFDIPYPTFVLYANRVHNMLGPSL---DGGADPRPKAR 703

  Fly   485 G----------------------------------------DGQHDGTL--DGIDNQRSHSFPNA 507
            |                                        :||..||.  .|......||...|
  Fly   704 GRPQRILLGMWPEELIRSVIKAVVFRDYREIKEDMSAHQYANGQGHGTYIGGGTTTNGYHSAAAA 768

  Fly   508 FLGLQGIPGLLP----GPSGINSDFVSRRSLEMRVR-----------------ATDPRPCPKCGK 551
            .|..|. ..|.|    .|....::.:.|:.|..:.:                 .....|..:...
  Fly   769 KLAAQN-AALAPPDAGSPLSSMTETLRRQILSQQQQHQQHHQQQAHHQQQPSHHQQQSPHAQSMN 832

  Fly   552 IYRS-AHTLRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDP 615
            :|:| |:..|:.:||:.:..    ..:....||     |.....:.||  :::||.|.
  Fly   833 MYKSPAYLQRSEIEDQVSAA----AAVAAAAAK-----HQQQQGERRG--SENLPDLS------- 879

  Fly   616 ELASRLLAKAGVKISPAELRARASPTGGSGSSGGGGGGGSSQAKLDLSNASGGPMDDAEDSDDDP 680
              |..|:...|:.:.|:.           ||.||.||...:.|   .|.|.....:...|.:.:.
  Fly   880 --ALGLMGLPGLNVMPSR-----------GSGGGSGGAAPNSA---ASYARELSRERERDRERER 928

  Fly   681 E-DLTTGNGLYGMGGSSSDLSRYHESLLSNFGHARMRNEAAAVAATAAALGQPKDLGVQLPNSNA 744
            | :|:...|....|.||...|.  :||.::      :...||...:||...:.:        ::|
  Fly   929 ERELSRQYGSQSRGSSSGSGSA--KSLTAS------QRPGAASPYSAAHYAKHQ--------ASA 977

  Fly   745 PGQSLLDTYLQFITENTFGMGMSQEQAAAAALRAKMAQLNAMGHSLDNLP------PGLLPGQFD 803
            ..:..|::....|....|..|:.|:                   |::..|      ||  ||| |
  Fly   978 YNKRFLESLPAGIDLEAFANGLLQK-------------------SVNKSPRFEDFFPG--PGQ-D 1020

  Fly   804 LSKLAAGNP-------AFGQSGPGLTIE-PIMR 828
            :|:|.| ||       |...:.||...| |:|:
  Fly  1021 MSELFA-NPDASAAAAAAAYAPPGAIRESPLMK 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	53/95 (56%)
		BTB	104..189	CDD:197585	48/84 (57%)
		zf-Di19	545..597	CDD:283297	10/52 (19%)
		C2H2 Zn finger	546..567	CDD:275371	6/21 (29%)
		C2H2 Zn finger	575..596	CDD:275371	3/20 (15%)
bab2	NP_523879.2	BTB	213..309	CDD:279045	53/95 (56%)
		BTB	224..309	CDD:197585	48/84 (57%)
		HTH_psq	645..690	CDD:283007	11/49 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447054
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.940