DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and fru

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster

Alignment Length:	928	Identity:	209/928 - (22%)
Similarity:	314/928 - (33%)	Gaps:	293/928 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LQTAENNNAGVVKMEPPPPATSSVSVSAAAAAHALSSLSSLTMAATGSALSPATPPPSLNLSH-- 69
            |||....|.......||||                       :......|.||:  |||.:|.
  Fly    62 LQTPHKRNIETDVRAPPPP-----------------------LPPPPLPLPPAS--PSLQISRYN 101

  Fly    70 -QQQQHQQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLK 133
             .|....|.:.|:||:..:::......|...|...||||||:..:..||:.:||||||||..:..
  Fly   102 TDQGAMDQQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSPYFETIFL 166

  Fly   134 ANPCEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKA 198
            .|...|||:.|:|||..::.:||.|||.|||||....||.|||||..||:|||.|
  Fly   167 QNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLTD---------- 221

  Fly   199 LSAALSHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNH-------NKISSYLSPNQTS--AACN 254
                      |||.|..|..:.|.::..::......||:       ..::..:..::.|  :.|.
  Fly   222 ----------NNNLNYRSDCDKLRDSAASSPTGRGPSNYTGGLGGAGGVADAMRESRDSLRSRCE 276

  Fly   255 NSSNSNSNNHSSSHNNSSSNNIS-------------GSLNSS-----LNSPFSAPQIPPPVTASS 301
            ..........|||..:..|:..:             |::|::     |.:|....:.|...:||:
  Fly   277 RDLRDELTQRSSSSMSERSSAAAAAAAAAAAVAAAGGNVNAAAVALGLTTPTGGERSPSVGSASA 341

  Fly   302 AAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQTSGTPAIQEL----------KASSAASPV 356
            ||||||.||::.||...:|:|...|...|......:|.....:.:|          .:||.....
  Fly   342 AAAAAAVAAAVAAAANRSASADGCSDRGSERGTLERTDSRDDLLQLDYSNKDNNNSNSSSTGGNN 406

  Fly   357 RNPNPNPSKASSSNHWDMG----------------EMEGSRKSHLTPPPQKRIKSADLFRAQHGI 405
            .|.|.|.:.:||:|:....                |.|..|...|:..|.:::.|:...|.....
  Fly   407 NNNNNNNNNSSSNNNNSSSNRERNNSGERERERERERERDRDRELSTTPVEQLSSSKRRRKNSSS 471

  Fly   406 SPERLL----LDREFPVAGQHPLTRN---RSGRDTSKDRER---------------------NLE 442
            :.:..|    .||.:|...|.....:   ::|..||:..:.                     |:.
  Fly   472 NCDNSLSSSHQDRHYPQDSQANFKSSPVPKTGGSTSESEDAGGRHDSPLSMTTSVHLGGGGGNVG 536

  Fly   443 LRESLLG--------QALENSNGQQANPKHE-----------------------LGQSAGEDSNS 476
            ...:|.|        |.|.::..||.:.:|.                       |.|.|.:.:::
  Fly   537 AASALSGLSQSLSIKQELMDAQQQQQHREHHVALPPDYLPSAALKLHAEDMSTLLTQHALQAADA 601

  Fly   477 SDTEPSDRGDGQHDGTLDGID--------------------NQRSHSFPNAFLGLQGIPGLLPGP 521
            .| |.:|....|.|.| |.||                    |.|.|         ...||::
  Fly   602 RD-EHNDAKQLQLDQT-DNIDGRVKCFNIKHDRHPDRELDRNHREH---------DDDPGVI--- 652

  Fly   522 SGINSDFVSRRSL-------EMRVRATDPRPCPKCGKIYRSAHTLRTHLEDKHT---------VC 570
            ..:..|.|.....       ||:..|....| ||    ||.|........|:..         |.
  Fly   653 EEVVVDHVREMEAGNEHDPEEMKEAAYHATP-PK----YRRAVVYAPPHPDEEAASGSGSDIYVD 712

  Fly   571 PGYRC-----------VLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASR--LL 622
            .||.|           :.|    ..:..:.||.|..|.  ..:.|...|..:|:.|.:|:.  .|
  Fly   713 GGYNCEYKCKELNMRAIRC----SRQQHMMSHYSPHHP--HHRSLIDCPAEAAYSPPVANNQAYL 771

  Fly   623 AKAGV------------------KISPAELRARASPTGGSGSSGGGGGGGSSQAKLDLSNASGGP 669
            |..|.                  :..|:......|.:.....|..|.|.|:....:.::.::.|.
  Fly   772 ASNGAVQQLDLSTYHGHANHQLHQHPPSATHPSHSQSSPHYPSASGAGAGAGSVSVSIAGSASGS 836

  Fly   670 MDDAEDS------DDDPEDLTTGNGLYGMGGSSSDLSRYHESLLSNFGHARMRNEAAAVAATAAA 728
            ...|..|      ...|...:||:                            .:.||||||.|||
  Fly   837 ATSAPASVATSAVSPQPSSSSTGS----------------------------TSSAAAVAAAAAA 873

  Fly   729 LGQPKD-------LGVQL 739
            ....:|       |.|||
  Fly   874 AANRRDHNIDYSTLFVQL 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	48/95 (51%)
		BTB	104..189	CDD:197585	46/84 (55%)
		zf-Di19	545..597	CDD:283297	15/71 (21%)
		C2H2 Zn finger	546..567	CDD:275371	6/20 (30%)
		C2H2 Zn finger	575..596	CDD:275371	5/31 (16%)
fru	NP_001163648.1	BTB	126..221	CDD:279045	48/94 (51%)
		BTB	137..221	CDD:197585	46/83 (55%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451885
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950