DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and CG6118

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001097806.1	Gene:	CG6118 / 41884	FlyBaseID:	FBgn0038339	Length:	967	Species:	Drosophila melanogaster

Alignment Length:	600	Identity:	147/600 - (24%)
Similarity:	220/600 - (36%)	Gaps:	191/600 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 PATPPPSLNLSH---------QQQQHQQ-------------------HYALKWNDFQSSILSSFR 94
            |:|||.:....|         |||.|||                   .|.|.||:|..::...|.
  Fly   345 PSTPPTTAQQIHITATQHQAAQQQLHQQQQQPSHKQQQSYADPNTIDQYLLSWNNFHGNMCRGFH 409

  Fly    95 HLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILRDVRCDDVENLLSFM 159
            .|:.:|..||||:|...:.|.|||:|||.|||||:::...||..|||:::.||....:..||.||
  Fly   410 SLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSSHPILLMADVEASHMAGLLDFM 474

  Fly   160 YNGEVNVSHEQLPDFLKTAHLLQIRGL----------ADVN------------------------ 190
            |:|:|||.:|.||.|||.|..::|:||          :|::
  Fly   475 YSGQVNVKYEDLPVFLKVAEAMKIKGLHTEKNLDSDASDISSPHESDGTECRYERGTHSVNITSG 539

  Fly   191 -----GGYPYSKALSAALSHNSSNNNNNNSSSNNS----------------------LSNNNNNN 228
                 ||.|.|:..|.:.|.|..|......||..|                      :.|.|.||
  Fly   540 HAAGYGGAPSSQQSSPSPSLNGPNRCPTPLSSGGSGNPNYAGFREHIKSKATLAETFMKNLNRNN 604

  Fly   229 NNNAESSNHNKI-SSYLSPNQTSAACNNSSNSNSNN----------------------------- 263
            |||..|:|:|.: .|..|.|.|.|..|:.:...:|:
  Fly   605 NNNNSSNNYNHLGGSNGSLNLTEADSNSFAILQANSKKMLDSARKQHKYLAKRKILMHYNTELGG 669

  Fly   264 -------------HSSSHNNSSSNNISGSLNSSLNSPFS--APQIPPPVTASSAAAAAAAAASLT 313
                         .:..|:::.:||.|.:.::.:....:  .||.|||.|.::         :..
  Fly   670 EKRLKEMERDRYPSAEQHDDALNNNHSHAQDNIMEPIITTIVPQTPPPSTHNN---------NFK 725

  Fly   314 AAVAAAAAATAASAGSSSSAASGQTSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEME 378
            ..:..:...|..|..:.:.:::..            :|::||..|...|..:|  .|...:....
  Fly   726 IRLVESHHLTNNSNNNQNQSSNNN------------NSSSSPQSNDCNNDEEA--LNLVQIPNAN 776

  Fly   379 GSRKSHLTP------PPQKRIKSADLFRAQHGISPERLLL-----DREFPVAG---QHPLTRNRS 429
            |||....||      |..:.||.    ..:..:||...|.     |.|...||   ::....|.|
  Fly   777 GSRNREATPTCATPTPDIQLIKR----EVKTELSPAENLSNNNGHDDEMAGAGFDRKYDDNNNNS 837

  Fly   430 GRDTSKDRERN-------------LELRESLLGQALENSNGQQANPKHEL--GQSAGEDSNSSDT 479
            |.|...|...|             |.|.:..|..|: |.|.:|.:|.||.  .|....|...::.
  Fly   838 GLDMETDSNNNNSKPGGDNNNGLALALGKHKLLSAI-NRNIEQDHPDHEHQDQQDREADHGGNNC 901

  Fly   480 EPSDRGDGQHDGTLD 494
            ...|..:..|...||
  Fly   902 NSDDNNNNNHSQHLD 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	46/105 (44%)
		BTB	104..189	CDD:197585	42/94 (45%)
		zf-Di19	545..597	CDD:283297
		C2H2 Zn finger	546..567	CDD:275371
		C2H2 Zn finger	575..596	CDD:275371
CG6118	NP_001097806.1	Myb_DNA-bind_4	20..97	CDD:290549
		BTB	408..508	CDD:279045	46/99 (46%)
		BTB	419..510	CDD:197585	42/90 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451877
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.950