DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and BtbVII

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	956	Identity:	208/956 - (21%)
Similarity:	304/956 - (31%)	Gaps:	323/956 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHP 140
            |.:.|:||:.|.:.:|....|......||||||.:.|...|||:||||||.||:.|...|||:||
  Fly     4 QQFCLRWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQHP 68

  Fly   141 IVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKA-LSAALS 204
            ||||:||:.||::.::.|||.||||||.||||..||||.:|:|:|||::    |...| |:.:.|
  Fly    69 IVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGLAEM----PTDPANLTKSDS 129

  Fly   205 HNSSNNN---------------------NNNSSSNNSL----------SNNNNNNNNNAESSNHN 238
            .:|::..                     .:.||..:||          ..........|:..:|:
  Fly   130 KSSTDGTEMVGGAGVGTGAGNSAGSLGAGSGSSVGDSLWSSSEAQQFQQQQQQQAQQQAQQQHHH 194

  Fly   239 -----------------------------------------------KISSYLSPNQTSAACNNS 256
                                                           :..|.||...:.|.....
  Fly   195 HQQQQQLQQQQQQAQQQQQQQQHHHHHHQQQQSGQAQAAQTHHHQMRRTPSPLSAGTSPATRRKR 259

  Fly   257 SNSNSNNHSSSHNNSSSNNISGSLNSSL-------NSPFSAPQIPPPVTASSAAAAAAAAASLTA 314
            ...:|||.|...||:...:     ||||       |:..|..|:.   ..:..|....|..||.|
  Fly   260 LRKSSNNGSGDRNNAEEQH-----NSSLDAGSGAGNAGLSLAQMN---QMTFGAGGGLAGHSLHA 316

  Fly   315 AVAAAAAATA-------------------------ASAGSSSSAASGQTSG--TPAIQELKAS-- 350
            |.....:|:|                         ...|..:.......||  ||:..:...|
  Fly   317 AKLLKESASAELEQQPQDSDLDDGHGHLHMQIKPEVDIGGVNQTMPLDISGGTTPSEHDAPNSQS 381

  Fly   351 --SAASPVRNPNP--NPSKASSSNHWDMGEMEGS--------------------------RKSHL 385
              |..||...|:|  .|..|:||:....|..|.|                          |...|
  Fly   382 SHSEPSPAHAPHPPHPPLGAASSSSGGSGSFERSFSIGGVGSVECDPDGTPSSPAVMGTKRNRVL 446

  Fly   386 TPPPQKRIKSADLFRAQHGISPE--RLLLD--------------REFPVAGQHPLTRN------- 427
            |..|:.: :.:|...:.:.|||:  ...||              |::...|.|.|...
  Fly   447 TRQPRVK-RDSDSISSTNQISPDTAATTLDFDPFNAAGATSATARDYSTTGSHHLHHQSAVHHHH 510

  Fly   428 -------RSGRDTS------------------------KDRERNLELRESLLGQALENSNGQQA- 460
                   |..|..|                        |.....|..|:|.|..|...|....|
  Fly   511 HLLTVPPRIERHASEPAPSLAPSTPHLLSVPSSTPYLIKQHSDPLLPRQSALHMAGSGSGSSSAM 575

  Fly   461 -------NPKHELGQSAGEDSNSSDTEPSDRGDGQHDGTLDGIDNQRSHSFPNAFLGLQGIPGLL 518
                   .|.|.........||:|...|:......|....:.|....|
  Fly   576 ATGSNPFAPLHRQYSHPLSGSNASYVTPAPLHHPHHISLPESIYASGS----------------- 623

  Fly   519 PGPSGINSDFVSRRSLEMRV-----RATDPRPCPKCGKIYRSAHTLRT-------HLEDKHTVCP 571
            |.|:|.:...|..|.:...|     .||.....|.......:|.::.|       :...:|.:.|
  Fly   624 PPPAGSSQYLVPTRVVACPVVSSETAATPTNASPGSSSTVSAAVSVVTSPNAGLQNSASRHPLSP 688

  Fly   572 GYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELA-SRLLAKAGVKISPAE-- 633
            .:.  :...||..|.|.||                        |.:: |:::.:||.  :|||
  Fly   689 TFS--IGSDVAHERRSPHS------------------------PSISRSQVVERAGK--NPAEAA 725

  Fly   634 ------LRARASPTG---GSGSSGGGGGGGSSQAKLDLSNASGGPMDDAEDSDDDPEDLTT---- 685
                  ||...|.:|   |:....|.....||...|.........:..:..|.....::.|
  Fly   726 NGGGSRLRTSKSASGSITGTHLHPGQATMSSSFEHLPTLRVKNEELQRSVSSPQTQREIITLENP 790

  Fly   686 -------------------GNGLYGMGGSSSDLSRYH-ESLLSNF--------GHARMRNEAAAV 722
                               .|.:.|.|......::|| ....:|.        .|.|:.|||||
  Fly   791 RSSHCPVIRPGPALGCNFCWNTIDGHGRILRRKTKYHCPECQTNLCIVPCFQEYHERLNNEAAA- 854

  Fly   723 AATAAALGQPKDLGVQLPNSNAPGQSLLDTYLQFITENTFGMGMSQ 768
            |::.||.|. ..|......|.:........|:.....::.|.|.::
  Fly   855 ASSGAAAGD-NQLSSSTTGSGSSSSGKASPYVSSAGSSSSGAGAAR 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	55/95 (58%)
		BTB	104..189	CDD:197585	53/84 (63%)
		zf-Di19	545..597	CDD:283297	11/58 (19%)
		C2H2 Zn finger	546..567	CDD:275371	3/27 (11%)
		C2H2 Zn finger	575..596	CDD:275371	6/20 (30%)
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	55/92 (60%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	53/84 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020