DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ab and psq

DIOPT Version :9

Sequence 1:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001369078.1	Gene:	psq / 36118	FlyBaseID:	FBgn0263102	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	999	Identity:	215/999 - (21%)
Similarity:	343/999 - (34%)	Gaps:	286/999 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHP 140
            |:::|:||::|:::.|.|:.||::..||||||:|:..|..||||||||||.||::||..|||:||
  Fly     8 QYFSLRWNNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHP 72

  Fly   141 IVIL-RDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLA-------DVNGGYPYSK 197
            .:|| .|:...|::.::.|:|.||::|:..:|...|:||..|:|:||.       |:|.....:.
  Fly    73 TIILPADIIFTDLKTIIDFVYRGEIDVTESELQGLLRTAEQLKIKGLCETAENADDLNDAATATI 137

  Fly   198 ALSAALSHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSN 262
            .:|..:......|..|.:....:.|.:......:.:.....:........|..|..........|
  Fly   138 TVSENIQQAVVGNIVNAAIVPGAPSPSLEQQQQHHQQQQQQQAQEQHQQQQVHAQQQQQQQQQIN 202

  Fly   263 -----NHSSSHNNSSSNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAA------- 315
                 .|..|   |.|.::||.|.||            ..:.||.:.|....||.|.:
  Fly   203 AALLTQHGVS---SGSVSLSGQLLSS------------SASGSSGSLAGGQQASQTPSGLQPTPR 252

  Fly   316 ------VAAAAAATAASAGSSSSAASGQTSGTP-----------AIQELKASSAASPVRNPNPNP 363
                  ..:...::...||||..::||.|...|           .||....:|..|..:..:.|.
  Fly   253 KSRLKRSKSPDLSSGGGAGSSGGSSSGSTQQQPQPAHHHHPQTILIQGQNPNSIVSLQQTADGNY 317

  Fly   364 SKASSS-----------------NHWDMGEMEGSRKSH-LTPPPQKRIKSADLFRAQHGI-SPER 409
            ...|.|                 .|...|...|...|| .:...:...|...:.:.:|.: ||..
  Fly   318 IPVSGSGDDSDAEDHEHEHNHGHGHGHGGHTHGHGHSHEHSHDHEHEHKPNKICKTEHSVASPAS 382

  Fly   410 LLLDREFPVAGQHPLTRN-----------RSGRDTSKDRERNLELRESLLGQAL------ENSNG 457
            .........||...:|..           |.|:||.......:.:...|||..:      .....
  Fly   383 NSSSASNNAAGVSGVTSTGQAIVTQIVVARDGKDTKNMTSLGMGMNGGLLGVPMGFLDFTPEPPA 447

  Fly   458 QQANP----KH-ELGQSAGEDSN--SSDTEPSDRGDGQHDGTLDGIDNQRSHSFPNAFLGLQGIP 515
            ..|.|    :| :|..:...|:.  |:.|||.|. |......:..:|....||..:...|.:...
  Fly   448 PSATPVTVTEHVDLSCNPSTDTRDLSNTTEPLDI-DNHLAQQIHRLDQSPMHSISHHHTGDESNS 511

  Fly   516 GLLPGPSGINSDFVSRRSLEMRVRATDPRPCPKCGKIYRSAHTL-RTHLEDKHTVCPGYRCVLCG 579
            .|:   ..|.|:.:..:.|..:..|...   .:....:..||.. :.|.:.:|
  Fly   512 NLV---QHIKSEVIEAKHLAAQHHALSQ---AQQQHAHHQAHQQHQQHQQQQH------------ 558

  Fly   580 TVAKSRNSLHS----------------------HMSR---------------QHRG-ISTKDL-- 604
              .:.:..||:                      |..:               ||.| ::..|:
  Fly   559 --QQQQQHLHAQQLLAQSQLQQQQQQQQQQQQHHQQQQQQAAAAAAAAGVHGQHGGHVTHADIGG 621

  Fly   605 -PVLPMPSAFDPELASRLLAKAGVKISP---------------------AELRARASP------- 640
             .|:.:    ||   |::..:.|:.|:|                     :.:.|..||
  Fly   622 ATVMEI----DP---SQIKHEPGMIITPEIVNMMSSGHMDMYNSDTSEDSMMIANGSPHDQKEPH 679

  Fly   641 ---------TGGS----GSSGGGGGGGSSQAKLDLSNASGGPMDDAEDS-DDDPEDLTTGNGLYG 691
                     .|||    |..|.|||||.|      ..|..|..:.|.|: .:....||..:.:||
  Fly   680 YTNLDQQHGLGGSVCGPGPGGAGGGGGMS------GGAGSGSGEKALDALKNQNMSLTKASAIYG 738

  Fly   692 M--------------------GGSSSDLSRYHESLLSN------------------FG------H 712
            :                    ||:.|    ::|..|.|                  ||      :
  Fly   739 IPSTTLWQRAHRMGIETPKKEGGTKS----WNEDALQNALEALRSGQISANKASKAFGIPSSTLY 799

  Fly   713 ARMRNEAAAVAA---TAAALGQPKDLGVQLPNSNAPGQSLLDTYLQF-ITENTF-------GMGM 766
            ...|.|...:||   .|.....|:||...|....|...|:.....:| |...|.       |:.:
  Fly   800 KIARREGIRLAAPFNAAPTTWTPEDLERALEAIRAGNTSVQKASAEFGIPTGTLYGRCKREGIEL 864

  Fly   767 SQ-------EQAAAAALRA-KMAQLNAMGHSLD-NLPPGLLPGQF-----DLSKLAAGNPAFGQS 817
            |:       |.|...||.: ::.|::....::. |||...|.|:|     |:....:|......|
  Fly   865 SRSNPTPWSEDAMNEALNSVRVGQMSINQAAIHYNLPYSSLYGRFKRGKYDVVANTSGVALLNTS 929

  Fly   818 GPGLTIEPIMRHEQAAGNLSPNRP 841
            |.......|:.|.|......|..|
  Fly   930 GNTTGSIEIIEHSQENSQQFPYSP 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ab	NP_476562.1	BTB	93..189	CDD:279045	47/103 (46%)
		BTB	104..189	CDD:197585	42/92 (46%)
		zf-Di19	545..597	CDD:283297	8/89 (9%)
		C2H2 Zn finger	546..567	CDD:275371	3/21 (14%)
		C2H2 Zn finger	575..596	CDD:275371	3/57 (5%)
psq	NP_001369078.1	BTB_POZ_BAB-like	34..118	CDD:349624	42/83 (51%)
		HTH_psq	717..>747	CDD:283007	6/29 (21%)
		HTH_psq	767..804	CDD:283007	5/36 (14%)
		HTH_psq	821..866	CDD:283007	10/44 (23%)
		HTH_psq	873..916	CDD:283007	11/42 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020